CMAUP Plant Collective Molecular Activities

Plant Name: Thalictrum alpinum

Plant ID: NPO27020
Plant Latin Name: Thalictrum alpinum
Taxonomy Genus: Thalictrum
Taxonomy Family: Ranunculaceae

NCBI TaxonomyDB: 395328
Plant-of-the-World-Online: n.a.

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALOX15;
Unclassified	MAPT;

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032273; positive regulation of protein polymerization	9.087E-05	2.818E-01	ALOX15, MAPT
BP	GO:0009987; cellular process	GO:1902905; positive regulation of supramolecular fiber organization	2.379E-04	2.818E-01	ALOX15, MAPT
BP	GO:0009987; cellular process	GO:0051495; positive regulation of cytoskeleton organization	3.022E-04	2.818E-01	ALOX15, MAPT
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	3.106E-04	2.818E-01	ALOX15
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.034E-04	2.818E-01	ALOX15, CYP3A4
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	3.106E-04	2.818E-01	ALOX15
CC	GO:0044464; cell part	GO:0030673; axolemma	2.483E-03	6.008E-01	MAPT
CC	GO:0044464; cell part	GO:0036464; cytoplasmic ribonucleoprotein granule	2.846E-02	1.000E+00	MAPT
CC	GO:0044425; membrane part	GO:0019898; extrinsic component of membrane	3.013E-02	1.000E+00	ALOX15

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	6.085E-06	7.910E-05	ALOX15, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6.884E-03	1.593E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.272E-03	1.593E-02	ALOX15
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.103E-02	1.593E-02	ALOX15, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.675E-03	1.593E-02	CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.719E-03	1.593E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.031E-02	1.593E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.091E-02	1.593E-02	CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.061E-02	1.593E-02	CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.225E-02	1.593E-02	CYP3A4

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases