CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALOX15;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Show entries

Search:

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Showing 1 to 3 of 3 entries

Previous1Next

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Show entries

Search:

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032273; positive regulation of protein polymerization	9.087E-05	2.818E-01	ALOX15, MAPT
BP	GO:0009987; cellular process	GO:1902905; positive regulation of supramolecular fiber organization	2.379E-04	2.818E-01	ALOX15, MAPT
BP	GO:0009987; cellular process	GO:0051495; positive regulation of cytoskeleton organization	3.022E-04	2.818E-01	ALOX15, MAPT
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	3.106E-04	2.818E-01	ALOX15
CC	GO:0044464; cell part	GO:0030673; axolemma	2.483E-03	6.008E-01	MAPT
CC	GO:0044464; cell part	GO:0036464; cytoplasmic ribonucleoprotein granule	2.846E-02	1.000E+00	MAPT
CC	GO:0044425; membrane part	GO:0019898; extrinsic component of membrane	3.013E-02	1.000E+00	ALOX15
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.034E-04	2.818E-01	ALOX15, CYP3A4
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	3.106E-04	2.818E-01	ALOX15

Showing 1 to 9 of 9 entries

Previous1Next

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Show entries

Search:

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	6.085E-06	7.910E-05	ALOX15, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6.884E-03	1.593E-02	CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.272E-03	1.593E-02	ALOX15
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	8.675E-03	1.593E-02	CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.719E-03	1.593E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.031E-02	1.593E-02	CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.091E-02	1.593E-02	CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.061E-02	1.593E-02	CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.225E-02	1.593E-02	CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.103E-02	1.593E-02	ALOX15, CYP3A4

Showing 1 to 10 of 10 entries

Previous1Next

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

Show entries

Search:

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Thalictrum alpinum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities