CMAUP Plant Collective Molecular Activities

Plant Name: Cynomorium songaricum

Taxonomic Information:

Plant ID: NPO27018
Plant Latin Name: Cynomorium songaricum
Taxonomy Genus: Cynomorium
Taxonomy Family: Cynomoriaceae

Plant External Links:

NCBI TaxonomyDB: 627609
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4; ADRA2B;
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	ALPL; RECQL; PGD; ALOX12; HSD17B10; ALOX15; NOX4; POLB;
Miscellaneous ion channel	BCL2;
Protein Kinase	MET; FLT3; CDK1; PIM1; AXL; KDR; IGF1R; AURKB;
Lyase	CA2; CA14; CA7;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Lysine demethylase	KDM4E;
Transcription Factor	NFKB1;
Transferase	FUT7;
Unclassified	LMNA; FABP3; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PGD	6-phosphogluconate dehydrogenase	P52209	CHEMBL3404
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Miscellaneous ion channel	BCL2	Apoptosis regulator Bcl-2	P10415	CHEMBL4860
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MET	Hepatocyte growth factor receptor	P08581	CHEMBL3717
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Protein Kinase	CDK1	Cyclin-dependent kinase 1	P06493	CHEMBL308
Protein Kinase	PIM1	Serine/threonine-protein kinase PIM1	P11309	CHEMBL2147
Protein Kinase	AXL	Tyrosine-protein kinase receptor UFO	P30530	CHEMBL4895
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	IGF1R	Insulin-like growth factor I receptor	P08069	CHEMBL1957
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Transferase	FUT7	Alpha-(1,3)-fucosyltransferase 7	Q11130	CHEMBL3596077
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.750E-08	2.382E-05	ALOX12, AURKB, AXL, BCL2, CDK1, FFAR4, IGF1R, KDR, LMNA, NFKB1, NR1H4, PIM1
MF	GO:0005488; binding	GO:0005504; fatty acid binding	1.539E-07	1.457E-04	FABP3, FABP4, FABP5, FFAR4
BP	GO:0065007; biological regulation	GO:0048878; chemical homeostasis	5.234E-07	3.930E-04	ALOX12, BCL2, CA2, CA7, FABP3, FABP4, FFAR1, MET, NOX4, NPSR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.443E-06	1.297E-03	CA14, CA2, CA7
BP	GO:0008152; metabolic process	GO:2001303; lipoxin A4 biosynthetic process	3.190E-06	1.478E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0047977; hepoxilin-epoxide hydrolase activity	3.190E-06	1.478E-03	ALOX12, ALOX15
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	9.558E-06	3.202E-03	CA2, CA7
BP	GO:0019740; nitrogen utilization	GO:0006808; regulation of nitrogen utilization	9.558E-06	3.202E-03	BCL2, NR1H4
MF	GO:0003824; catalytic activity	GO:0004052; arachidonate 12-lipoxygenase activity	9.558E-06	3.202E-03	ALOX12, ALOX15
MF	GO:0003824; catalytic activity	GO:0051120; hepoxilin A3 synthase activity	9.558E-06	3.202E-03	ALOX12, ALOX15
MF	Unclassified;	GO:0004872; receptor activity	1.029E-05	3.249E-03	ADRA2B, AXL, FFAR1, FFAR4, FLT3, IGF1R, KDR, MET, NPSR1, NR1H4, PPARA, RORC
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.220E-05	3.638E-03	FABP3, FABP4, FABP5
BP	GO:0050896; response to stimulus	GO:0009725; response to hormone	1.850E-05	5.100E-03	ALPL, BCL2, CA2, FABP3, FFAR4, FLT3, NFKB1, PPARA
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	2.014E-05	5.334E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0002376; immune system process	GO:0030098; lymphocyte differentiation	2.121E-05	5.498E-03	AXL, BCL2, FLT3, FUT7, RORC
BP	GO:0008152; metabolic process	GO:0046777; protein autophosphorylation	2.591E-05	6.132E-03	AURKB, FLT3, IGF1R, KDR, PIM1
MF	GO:0005488; binding	GO:0008144; drug binding	3.008E-05	6.752E-03	AURKB, AXL, CDK1, CYP1B1, FLT3, IGF1R, KDR, MET, NOX4, PIM1, PPARA, RECQL
BP	GO:0008152; metabolic process	GO:0051122; hepoxilin biosynthetic process	3.179E-05	6.922E-03	ALOX12, ALOX15
BP	GO:0008152; metabolic process	GO:0072593; reactive oxygen species metabolic process	3.383E-05	7.210E-03	ALOX12, BCL2, CYP1B1, NOX4
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	3.444E-05	7.210E-03	BCL2, CA2, CA7, KDR, NPSR1
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	3.588E-05	7.440E-03	ALPL, CYP1B1, FLT3, NFKB1, NOX4, RORC

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	6.266E-06	3.697E-04	FABP3, FABP4, FABP5, PPARA
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.283E-06	3.697E-04	CA2, CA7, CA14
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	1.346E-04	4.641E-03	FLT3, PIM1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05206	MicroRNAs in cancer	1.573E-04	4.641E-03	PIM1, BCL2, CYP1B1, MET, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04151	PI3K-Akt signaling pathway	2.983E-04	5.867E-03	KDR, BCL2, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	5.973E-04	7.573E-03	FLT3, BCL2, MET, NFKB1, IGF1R
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04510	Focal adhesion	4.139E-04	6.976E-03	KDR, BCL2, MET, IGF1R
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	2.672E-04	5.867E-03	FLT3, MET, NFKB1, IGF1R
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	5.029E-04	7.418E-03	BCL2, NFKB1, IGF1R
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	6.420E-04	7.573E-03	KDR, MET, NFKB1, IGF1R
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04933	AGE-RAGE signaling pathway in diabetic complications	7.275E-04	7.573E-03	PIM1, BCL2, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	7.702E-04	7.573E-03	BCL2, NFKB1, IGF1R

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3; BCL2;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
I00-I99: Diseases of the circulatory system	Heart disease	I00-I52	MET;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MET; AURKB; IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Glioblastoma	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	FLT3; BCL2;
G00-G99: Diseases of the nervous system G00-G99	Amyotrophic lateral sclerosis	G12.2	BCL2;
NA: NA	Anaplastic mixed oligoastrocytoma	NA	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriatic disorder	L40	IGF1R;
C00-D49: Neoplasms	Myeloid leukemia	C92	FLT3;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
C00-D49: Neoplasms	Metastatic HER2-negative gastric cancer	NA	MET;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADRA2B;
C00-D49: Neoplasms	AML	NA	KDR; FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3; BCL2;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
J00-J99: Diseases of the respiratory system	Airway inflammation	J00-J99	FLT3;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	MET;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2B;
C00-D49: Neoplasms	Metastasis	C00-C97	AXL;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
K00-K95: Diseases of the digestive system	Chemotherapy-induced mucositis	K12.3	MET;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Advanced melanoma	C43	BCL2;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	MET; IGF1R; KDR; AXL;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
C00-D49: Neoplasms	Malignant adrenal gland cancer	C74.0	IGF1R;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; FFAR1;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	FLT3;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKB; FLT3;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
H00-H59: Diseases of the eye and adnexa	Graves' ophthalmopathy	H06.2	IGF1R;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
C00-D49: Neoplasms	CLL	NA	FLT3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CDK1; IGF1R;
C00-D49: Neoplasms	Gliosarcoma	NA	FLT3;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Breast cancer	C50	CDK1; IGF1R; KDR; FLT3; BCL2;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	MET; IGF1R; KDR;
C00-D49: Neoplasms	Chronic lymphocytic leukaemia	C91	BCL2;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Cancer	C00-C96	PIM1; MET; CDK1; IGF1R; KDR; NFKB1; FLT3; BCL2;
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
C00-D49: Neoplasms	Multiple myeloma	C90	IGF1R; BCL2;
G00-G99: Diseases of the nervous system G00-G99	Motor neurone disease	G12.2	IGF1R;
C00-D49: Neoplasms	Glioma	C71	KDR;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	MET;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; ALPL;
NA: NA	Hematopoietic stem cell transplantation	NA	FLT3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Myelofibrosis	C94.4, D47.4	FLT3;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
E00-E89: Endocrine, nutritional and metabolic diseases	Hormone deficiency	E00-E90	IGF1R;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR; FLT3;
K00-K95: Diseases of the digestive system	Liver disease	K70-K77	MET;
C00-D49: Neoplasms	Lymphoma	C81-C86	BCL2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Growth failure	R62.8	IGF1R;
NA: NA	GIST	NA	FLT3;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases