CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	USP2;
Unclassified	NPC1; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0007610; behavior	GO:0007610; behavior	2.173E-05	4.732E-01	MAPT, NPC1, USP2
BP	GO:0065007; biological regulation	GO:0010952; positive regulation of peptidase activity	2.678E-02	1.000E+00	MAPT
BP	GO:0009987; cellular process	GO:2001020; regulation of response to DNA damage stimulus	2.755E-02	1.000E+00	MAPT
BP	GO:0009987; cellular process	GO:0051495; positive regulation of cytoskeleton organization	2.998E-02	1.000E+00	MAPT
BP	GO:0065007; biological regulation	GO:0043281; regulation of cysteine-type endopeptidase activity involved in apoptotic process	3.166E-02	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0034452; dynactin binding	1.708E-03	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0034185; apolipoprotein binding	2.483E-03	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0031072; heat shock protein binding	1.622E-02	1.000E+00	MAPT
MF	GO:0005488; binding	GO:0019903; protein phosphatase binding	1.822E-02	1.000E+00	MAPT

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	3.777E-02	3.777E-02	MAPT
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	1.834E-02	3.749E-02	NPC1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	2.499E-02	3.749E-02	MAPT

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Stephania erecta

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities