Plant Name: Stephania erecta
Taxonomic Information:
Plant ID: NPO26964
Plant Latin Name: Stephania erecta
Taxonomy Genus: Stephania
Taxonomy Family: Menispermaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | USP2 | Ubiquitin carboxyl-terminal hydrolase 2 | O75604 | CHEMBL1293227 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0007610; behavior | GO:0007610; behavior | 2.173E-05 | 4.732E-01 | MAPT, NPC1, USP2 |
| BP | GO:0065007; biological regulation | GO:0010952; positive regulation of peptidase activity | 2.678E-02 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:2001020; regulation of response to DNA damage stimulus | 2.755E-02 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:0051495; positive regulation of cytoskeleton organization | 2.998E-02 | 1.000E+00 | MAPT |
| BP | GO:0065007; biological regulation | GO:0043281; regulation of cysteine-type endopeptidase activity involved in apoptotic process | 3.166E-02 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 1.708E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0034185; apolipoprotein binding | 2.483E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0031072; heat shock protein binding | 1.622E-02 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0019903; protein phosphatase binding | 1.822E-02 | 1.000E+00 | MAPT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 1.834E-02 | 3.749E-02 | NPC1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 2.499E-02 | 3.749E-02 | MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 3.777E-02 | 3.777E-02 | MAPT |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
