CMAUP Plant Collective Molecular Activities

Plant Name: Vigna radiata

Taxonomic Information:

Plant ID: NPO26902
Plant Latin Name: Vigna radiata
Taxonomy Genus: Vigna
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 157791
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Thailand; Indonesia; India

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Ayurveda; Siddha

Geographical Distribution:

Thailand; Indonesia; India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family C GPCR)	GRM8; GRM1;
Small molecule receptor (family A GPCR)	ADRA2B; ADORA3; HCAR2;
Enzyme_unclassified	BLM;
Ionotropic glutamate receptor	GRIA4; GRIA2; GRIK3; GRIK5; GRIK1;
Protein Kinase	MAPK1;
Transcription Factor	NFKB1;
SLC superfamily of solute carriers	SLC1A1; SLCO1B1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Ionotropic glutamate receptor	GRIA4	Glutamate receptor ionotropic, AMPA 4	P48058	CHEMBL3190
Ionotropic glutamate receptor	GRIA2	Glutamate receptor ionotropic, AMPA 2	P42262	CHEMBL4016
Ionotropic glutamate receptor	GRIK3	Glutamate receptor ionotropic kainate 3	Q13003	CHEMBL3684
Ionotropic glutamate receptor	GRIK5	Glutamate receptor ionotropic kainate 5	Q16478	CHEMBL2675
Ionotropic glutamate receptor	GRIK1	Glutamate receptor ionotropic kainate 1	P39086	CHEMBL1918
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
SLC superfamily of solute carriers	SLC1A1	Excitatory amino acid transporter 3	P43005	CHEMBL2721
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	ADRA2B	Alpha-2b adrenergic receptor	P18089	CHEMBL1942
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	HCAR2	Hydroxycarboxylic acid receptor 2	Q8TDS4	CHEMBL3785
Small molecule receptor (family C GPCR)	GRM8	Metabotropic glutamate receptor 8	O00222	CHEMBL3228
Small molecule receptor (family C GPCR)	GRM1	Metabotropic glutamate receptor 1	Q13255	CHEMBL3772
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005215; transporter activity	GO:0005234; extracellularly glutamate-gated ion channel activity	2.253E-12	1.226E-08	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0035235; ionotropic glutamate receptor signaling pathway	1.270E-11	5.532E-08	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
BP	GO:0023052; signaling	GO:0060079; excitatory postsynaptic potential	2.126E-09	3.561E-06	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0015277; kainate selective glutamate receptor activity	4.658E-09	6.339E-06	GRIK1, GRIK3, GRIK5
BP	GO:0009987; cellular process	GO:0007196; adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway	3.905E-08	4.049E-05	GRIK3, GRM1, GRM8
MF	Unclassified;	GO:0004872; receptor activity	5.670E-08	5.144E-05	ADORA3, ADRA2B, GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, GRM1, GRM8, HCAR2
BP	GO:0023052; signaling	GO:0051966; regulation of synaptic transmission, glutamatergic	1.390E-07	8.902E-05	GRIK1, GRIK3, GRM1, GRM8
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	5.875E-07	3.286E-04	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
MF	GO:0005215; transporter activity	GO:0004971; AMPA glutamate receptor activity	3.856E-06	1.646E-03	GRIA2, GRIA4
MF	GO:0005215; transporter activity	GO:0008381; mechanosensitive ion channel activity	5.522E-06	2.186E-03	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5
CC	GO:0044425; membrane part	GO:0008328; ionotropic glutamate receptor complex	6.926E-06	2.600E-03	GRIA2, GRIA4, GRIK5
BP	GO:0023052; signaling	GO:0023051; regulation of signaling	9.666E-06	3.341E-03	ADRA2B, BLM, GRIK1, GRIK3, GRIK5, GRM1, GRM8, HCAR2, LMNA, MAPK1, NFKB1
CC	GO:0044456; synapse part	GO:0042734; presynaptic membrane	1.712E-05	5.481E-03	GRIK5, GRM1, GRM8
CC	GO:0030054; cell junction	GO:0030054; cell junction	2.563E-05	7.752E-03	GRIA2, GRIA4, GRIK1, GRIK3, GRIK5, HCAR2, MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04724	Glutamatergic synapse	5.093E-17	6.010E-15	GRIA2, GRIK5, SLC1A1, GRM8, GRIK3, MAPK1, GRIK1, GRM1, GRIA4
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.731E-13	1.021E-11	GRIA2, GRIK5, ADORA3, GRM8, GRIK3, GRIK1, ADRA2B, GRM1, GRIA4
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	3.706E-07	1.458E-05	HCAR2, GRIA2, MAPK1, NFKB1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	1.064E-06	3.139E-05	GRIA2, MAPK1, GRM1, GRIA4
09150 Organismal Systems	09156 Nervous system	hsa04730	Long-term depression	1.398E-05	3.299E-04	GRIA2, MAPK1, GRM1
09150 Organismal Systems	09156 Nervous system	hsa04720	Long-term potentiation	1.864E-05	3.666E-04	GRIA2, MAPK1, GRM1
09150 Organismal Systems	09159 Environmental adaptation	hsa04713	Circadian entrainment	5.559E-05	9.371E-04	GRIA2, MAPK1, GRIA4
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.759E-04	2.255E-03	LMNA, MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.114E-04	1.644E-03	ADORA3, MAPK1, NFKB1
09130 Environmental Information Processing	09132 Signal transduction	hsa04072	Phospholipase D signaling pathway	1.911E-04	2.255E-03	GRM8, MAPK1, GRM1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	2.956E-04	3.171E-03	ADORA3, MAPK1, ADRA2B
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	9.334E-04	7.343E-03	MAPK1, NFKB1
09160 Human Diseases	09164 Substance dependence	hsa05033	Nicotine addiction	4.598E-04	4.521E-03	GRIA2, GRIA4
09160 Human Diseases	09164 Substance dependence	hsa05030	Cocaine addiction	6.903E-04	6.266E-03	GRIA2, NFKB1
09160 Human Diseases	09161 Cancers	hsa05212	Pancreatic cancer	1.249E-03	8.182E-03	MAPK1, NFKB1
09160 Human Diseases	09164 Substance dependence	hsa05031	Amphetamine addiction	1.287E-03	8.182E-03	GRIA2, GRIA4
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	9.334E-04	7.343E-03	MAPK1, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.484E-03	8.182E-03	MAPK1, NFKB1
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	1.526E-03	8.182E-03	MAPK1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04662	B cell receptor signaling pathway	1.526E-03	8.182E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	1.212E-03	8.182E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.526E-03	8.182E-03	MAPK1, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	1.609E-03	8.257E-03	MAPK1, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	GRM1; GRIK1;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	HCAR2;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1; ADORA3; MAPK1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	GRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	GRM1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2B; GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	GRM1;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	HCAR2;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	GRIK1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADORA3;
I00-I99: Diseases of the circulatory system	Acute ischemic stroke	I61-I63	HCAR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1; HCAR2;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	HCAR2;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	HCAR2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	GRIA2; GRIA4;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	GRM1; GRIK1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	GRM1; ADRA2B; GRIK1;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	HCAR2;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases