CMAUP Plant Collective Molecular Activities

Plant Name: Carapichea ipecacuanha

Taxonomic Information:

Plant ID: NPO2690
Plant Latin Name: Carapichea ipecacuanha
Taxonomy Genus: Carapichea
Taxonomy Family: Rubiaceae

Plant External Links:

NCBI TaxonomyDB: 77880
Plant-of-the-World-Online: 1214950-2

Used in Medicines:

Country/Region:

Brazil; Malaysia; Indonesia; India; Sri Lanka

Traditional Medicine System:

Unani; Indian Folk; Homeopathy; Siddha

Geographical Distribution:

Brazil; Indonesia; India; Costa Rica; Malaysia; Colombia; Sri Lanka; Nicaragua

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	TDP1; RBBP9; MTOR;
Hydrolase	GAA;
Bromodomain	KAT2B; EP300;
SLC superfamily of solute carriers	SLC2A1;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Bromodomain	KAT2B	Histone acetyltransferase PCAF	Q92831	CHEMBL5500
Bromodomain	EP300	Histone acetyltransferase p300	Q09472	CHEMBL3784
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RBBP9	Putative hydrolase RBBP9	O75884	CHEMBL1075121
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
SLC superfamily of solute carriers	SLC2A1	Glucose transporter	P11166	CHEMBL2535
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0018076; N-terminal peptidyl-lysine acetylation	1.463E-06	9.097E-03	EP300, KAT2B
BP	GO:0065007; biological regulation	GO:0032148; activation of protein kinase B activity	1.790E-06	9.097E-03	ADRA2A, ADRA2C, MTOR
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	2.924E-06	9.097E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	2.924E-06	9.097E-03	ADRA2A, ADRA2C
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	1.463E-06	9.097E-03	ADRA2A, ADRA2C
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	2.924E-06	9.097E-03	CYP1A2, CYP3A4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	7.305E-06	1.224E-02	CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004468; lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	7.305E-06	1.224E-02	EP300, KAT2B
MF	GO:0005488; binding	GO:0051379; epinephrine binding	1.363E-05	1.745E-02	ADRA2A, ADRA2C
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	3.206E-05	2.844E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	3.788E-05	2.844E-02	SMN1, SMN2
MF	GO:0005488; binding	GO:0031690; adrenergic receptor binding	7.414E-05	4.485E-02	ADRA2A, ADRA2C
CC	GO:0044464; cell part	GO:0034719; SMN-Sm protein complex	7.414E-05	4.485E-02	SMN1, SMN2
CC	GO:0044422; organelle part	GO:0030018; Z disc	8.299E-05	4.884E-02	SLC2A1, SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	1.101E-06	6.827E-05	KAT2B, SLC2A1, EP300, MTOR
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	4.633E-05	1.436E-03	SLC2A1, EP300, MTOR
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.828E-04	3.777E-03	CYP1A2, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05166	HTLV-I infection	6.952E-04	5.147E-03	KAT2B, SLC2A1, EP300
09130 Environmental Information Processing	09132 Signal transduction	hsa04330	Notch signaling pathway	5.039E-04	5.147E-03	KAT2B, EP300
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8.543E-04	5.147E-03	ADRA2C, ADRA2A, TSHR
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	7.355E-04	5.147E-03	CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05211	Renal cell carcinoma	9.514E-04	5.147E-03	SLC2A1, EP300
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	9.229E-04	5.147E-03	CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	9.802E-04	5.147E-03	SLC2A1, MTOR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.039E-03	5.147E-03	CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.401E-03	8.270E-03	SLC2A1, EP300, MTOR
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	1.069E-03	5.147E-03	SLC2A1, MTOR
09160 Human Diseases	09161 Cancers	hsa05215	Prostate cancer	1.721E-03	6.669E-03	EP300, MTOR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.162E-03	5.147E-03	CYP1A2, CYP3A4
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	1.100E-03	5.147E-03	SLC2A1, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04922	Glucagon signaling pathway	2.209E-03	8.055E-03	SLC2A1, EP300
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.464E-03	6.049E-03	CYP1A2, CYP3A4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.566E-03	8.374E-03	SLC2A1, MTOR

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	ADRA2C;
L00-L99: Diseases of the skin and subcutaneous tissue	Erythema	L51-L54	ADRA2C;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Fibromyalgia	M79.7	ADRA2C;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADRA2C;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Attention deficit hyperactivity disorder	F90	ADRA2A;
I00-I99: Diseases of the circulatory system	Hypotension	I95	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Male sexual disorders	F52	ADRA2C;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	ADRA2A;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ADRA2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	ADRA2C;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	ADRA2C;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	ADRA2C;
H00-H59: Diseases of the eye and adnexa	Ocular disease	H00-H59	ADRA2C;
H00-H59: Diseases of the eye and adnexa	Ocular hypertension	H40.0	ADRA2C;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetic nephropathy	E11.21	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ADRA2C;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADRA2C;
S00-T88: Injury, poisoning and certain other consequences of external causes	Contusion	S36.220S	ADRA2C;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ADRA2A; ADRA2C;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	ADRA2C;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases