Plant Name: Croton zehntneri
Taxonomic Information:
Plant ID: NPO26881
Plant Latin Name: Croton zehntneri
Taxonomy Genus: Croton
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| GAA; | |
| TDP1; BLM; TNKS; PARP1; TNKS2; POLB; | |
| CA12; CA7; CA4; | |
| ESR1; ESR2; | |
| ALOX5; ALDH2; | |
| TP53; NFKB1; | |
| RAB9A; LMNA; NPC1; MAPT; THPO; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 1 | CYP1B1 | Cytochrome P450 1B1 | Q16678 | CHEMBL4878 |
| Cytochrome P450 family 19 | CYP19A1 | Cytochrome P450 19A1 | P11511 | CHEMBL1978 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
| Enzyme_unclassified | TNKS | Tankyrase-1 | O95271 | CHEMBL6164 |
| Enzyme_unclassified | PARP1 | Poly [ADP-ribose] polymerase-1 | P09874 | CHEMBL3105 |
| Enzyme_unclassified | TNKS2 | Tankyrase-2 | Q9H2K2 | CHEMBL6154 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
| Lyase | CA4 | Carbonic anhydrase IV | P22748 | CHEMBL3729 |
| Nuclear hormone receptor subfamily 3 group A | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
| Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
| Oxidoreductase | ALOX5 | Arachidonate 5-lipoxygenase | P09917 | CHEMBL215 |
| Oxidoreductase | ALDH2 | Aldehyde dehydrogenase | P05091 | CHEMBL1935 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 3.461E-09 | 3.768E-05 | CYP19A1, CYP1B1, CYP2C19, CYP2C9, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 2.746E-08 | 1.993E-04 | CYP19A1, CYP1B1, CYP2C19, CYP2C9, CYP2D6, ESR1, NPC1 |
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 4.318E-08 | 2.351E-04 | CYP2C19, CYP2C9, CYP2D6 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 5.902E-08 | 2.570E-04 | ALOX5, CYP19A1, CYP1B1, CYP2C19, CYP2C9, CYP2D6 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 1.163E-07 | 3.619E-04 | CYP19A1, CYP2C19, CYP2C9, CYP2D6 |
| BP | GO:0008152; metabolic process | GO:0097267; omega-hydroxylase P450 pathway | 2.582E-07 | 5.111E-04 | CYP1B1, CYP2C19, CYP2C9 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 6.496E-07 | 1.131E-03 | BLM, CA12, CA4, CA7, ESR1, ESR2, PARP1, TNKS, TP53 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 6.950E-07 | 1.131E-03 | CYP19A1, CYP1B1, CYP2C19, CYP2C9, CYP2D6 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 9.745E-07 | 1.292E-03 | CA12, CA4, CA7 |
| MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 1.742E-06 | 1.856E-03 | ESR1, ESR2 |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 2.293E-06 | 2.171E-03 | ALOX5, LMNA, NPC1, PARP1, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 2.833E-06 | 2.322E-03 | CYP1B1, CYP2C19, CYP2C9 |
| MF | GO:0003824; catalytic activity | GO:0070330; aromatase activity | 3.766E-06 | 2.828E-03 | CYP19A1, CYP1B1, CYP2D6 |
| MF | GO:0003824; catalytic activity | GO:0003950; NAD+ ADP-ribosyltransferase activity | 5.514E-06 | 3.639E-03 | PARP1, TNKS, TNKS2 |
| BP | GO:0065007; biological regulation | GO:1904357; negative regulation of telomere maintenance via telomere lengthening | 6.198E-06 | 3.969E-03 | PARP1, TNKS, TNKS2 |
| BP | GO:0008152; metabolic process | GO:0070213; protein auto-ADP-ribosylation | 1.044E-05 | 6.142E-03 | TNKS, TNKS2 |
| MF | GO:0005488; binding | GO:0034056; estrogen response element binding | 1.044E-05 | 6.142E-03 | ESR1, ESR2 |
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 1.501E-05 | 7.917E-03 | CA12, CA4, CA7 |
| BP | GO:0008152; metabolic process | GO:0006805; xenobiotic metabolic process | 1.556E-05 | 7.917E-03 | CYP1B1, CYP2C19, CYP2C9, CYP2D6 |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 5.763E-05 | 2.059E-02 | BLM, CA4, CYP19A1, CYP1B1, CYP2C19, CYP2C9, CYP2D6, ESR1, ESR2, GAA, LMNA, MAPT, NFKB1, NPC1, PARP1, POLB, RAB9A, TDP1, TNKS, TNKS2, TP53 |
| CC | GO:0044422; organelle part | GO:0000781; chromosome, telomeric region | 6.628E-05 | 2.144E-02 | BLM, PARP1, TNKS, TNKS2 |
| CC | GO:0016020; membrane | GO:0031090; organelle membrane | 8.230E-05 | 2.524E-02 | ALOX5, CA4, CYP1B1, CYP2C19, CYP2C9, CYP2D6, GAA, LMNA, NPC1, RAB9A, TNKS, TNKS2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.267E-05 | 6.777E-04 | CYP2C9, CYP2D6, ALOX5, CYP2C19 |
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.310E-06 | 1.402E-04 | CA12, CA4, CA7 |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 3.050E-05 | 9.819E-04 | PARP1, LMNA, TP53, NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04913 | Ovarian steroidogenesis | 3.671E-05 | 9.819E-04 | ALOX5, CYP1B1, CYP19A1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 7.010E-05 | 1.500E-03 | CYP2C9, ALOX5, CYP2C19 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 1.096E-04 | 1.527E-03 | ESR1, NFKB1, ESR2 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 9.653E-05 | 1.527E-03 | CYP2C9, CYP2D6, CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.142E-04 | 1.527E-03 | CYP2C9, CYP2D6, CYP1B1 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.613E-04 | 1.918E-03 | CYP2C9, CYP1B1, CYP2C19 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 7.131E-04 | 6.936E-03 | RAB9A, TP53, NFKB1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 6.457E-04 | 6.909E-03 | CYP2C9, CYP2C19 |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 8.370E-04 | 7.464E-03 | POLB, PARP1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| H00-H59: Diseases of the eye and adnexa | Ocular hypertension | H40.0 | CA4; |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | CA4; |
| A00-B99: Certain infectious and parasitic diseases | Bacterial infections | A00-B99 | CYP2C9; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
