CMAUP Plant Collective Molecular Activities

Plant Name: Diphylleia sinensis

Taxonomic Information:

Plant ID: NPO26868
Plant Latin Name: Diphylleia sinensis
Taxonomy Genus: Diphylleia
Taxonomy Family: Berberidaceae

Plant External Links:

NCBI TaxonomyDB: 382113
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Antiseptic; Cancer

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Enzyme_unclassified	CTDSP1; TDP1; HSD17B1; AKR1B1; HSD17B2; ALOX15; NOX4;
Protein Kinase	DAPK1; FLT3;
Lyase	CA2; CA12; CA7;
Nuclear hormone receptor subfamily 3 group C	AR;
Nuclear hormone receptor subfamily 3 group B	ESRRA;
Oxidoreductase	ALOX5; TYR; XDH;
Transcription Factor	AHR; HIF1A; TP53;
ATP-binding cassette	ABCG2; ABCC1;
Unclassified	HTT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCG2	ATP-binding cassette sub-family G member 2	Q9UNQ0	CHEMBL5393
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Enzyme_unclassified	CTDSP1	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	Q9GZU7	CHEMBL1795098
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	HSD17B1	Estradiol 17-beta-dehydrogenase 1	P14061	CHEMBL3181
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	NOX4	NADPH oxidase 4	Q9NPH5	CHEMBL1250375
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Nuclear hormone receptor subfamily 3 group B	ESRRA	Estrogen-related receptor alpha	P11474	CHEMBL3429
Nuclear hormone receptor subfamily 3 group C	AR	Androgen Receptor	P10275	CHEMBL1871
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	DAPK1	Death-associated protein kinase 1	P53355	CHEMBL2558
Protein Kinase	FLT3	Tyrosine-protein kinase receptor FLT3	P36888	CHEMBL1974
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.595E-12	3.102E-08	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	6.436E-11	2.247E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, NOX4
MF	GO:0005488; binding	GO:0005506; iron ion binding	9.318E-11	2.536E-07	ALOX15, ALOX5, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, XDH
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.273E-10	2.771E-07	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0020037; heme binding	3.922E-08	3.882E-05	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9, NOX4
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	6.740E-08	5.870E-05	CYP1A2, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	7.367E-07	4.456E-04	CYP1A2, CYP2C19, CYP2C9
BP	GO:0050896; response to stimulus	GO:0033993; response to lipid	9.570E-07	5.343E-04	AR, CA2, CYP1A1, CYP1A2, ESRRA, FLT3, HSD17B2, TP53, TYR
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.519E-06	7.875E-04	CA12, CA2, CA7
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	5.768E-06	2.364E-03	CYP1B1, HIF1A, NOX4, TP53, XDH
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	5.863E-06	2.364E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	5.863E-06	2.364E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	6.989E-06	2.624E-03	CA2, CA7
BP	GO:0032502; developmental process	GO:0048513; animal organ development	7.317E-06	2.700E-03	AR, CA2, CYP1A1, CYP1A2, ESRRA, FLT3, HIF1A, HSD17B2, HTT, TYR
BP	GO:0050896; response to stimulus	GO:0010038; response to metal ion	8.227E-06	2.958E-03	ALOX15, CA2, CYP1A1, CYP1A2, HIF1A, TP53
BP	GO:0009987; cellular process	GO:0034599; cellular response to oxidative stress	1.128E-05	3.559E-03	AKR1B1, CYP1B1, DAPK1, NOX4, TP53
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	1.292E-05	3.906E-03	ABCC1, AKR1B1, CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.396E-05	4.001E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.396E-05	4.001E-03	CYP1A2, CYP2C9
BP	GO:0008152; metabolic process	GO:0006691; leukotriene metabolic process	1.476E-05	4.173E-03	ABCC1, ALOX15, ALOX5
BP	GO:0009987; cellular process	GO:2001237; negative regulation of extrinsic apoptotic signaling pathway	1.878E-05	5.076E-03	AR, DAPK1, HTT, LMNA
BP	GO:0008283; cell proliferation	GO:0042127; regulation of cell proliferation	1.890E-05	5.076E-03	AHR, AKR1B1, AR, CYP1B1, ESRRA, FLT3, HIF1A, LMNA, NOX4, TP53, XDH
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.958E-05	5.076E-03	CYP1A1, CYP2C19, CYP2C9
BP	GO:0065007; biological regulation	GO:0030003; cellular cation homeostasis	2.047E-05	5.243E-03	ABCG2, CA2, CA7, HIF1A, HTT, NPSR1, TP53
MF	GO:0003824; catalytic activity	GO:0009055; electron transfer activity	2.264E-05	5.667E-03	AKR1B1, CYP1A2, NOX4, XDH
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.332E-05	5.761E-03	CA12, CA2, CA7
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	3.484E-05	8.247E-03	ALOX15, ALOX5
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.289E-05	9.831E-03	CA12, CA2, CA7

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.081E-08	8.323E-07	HSD17B1, ALOX5, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	2.318E-08	8.925E-07	HSD17B1, CYP1A2, HSD17B2, CYP1A1, CYP1B1
Unclassified	Unclassified	hsa01100	Metabolic pathways	9.019E-07	1.389E-05	CYP2C9, HSD17B1, ALOX5, HSD17B2, CYP1A2, ALOX15, CYP1A1, AKR1B1, CYP2C19, TYR, XDH
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	9.516E-08	2.442E-06	CYP2C9, CYP1A2, ALOX15, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.346E-07	2.592E-06	CYP2C9, CYP1A2, CYP1A1, CYP1B1, CYP2C19
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.159E-06	2.375E-05	CYP2C9, ALOX5, ALOX15, CYP2C19
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	4.165E-06	4.009E-05	CYP2C9, CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.282E-05	1.757E-04	CYP2C9, ALOX5, ALOX15, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	2.898E-05	2.029E-04	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05200	Pathways in cancer	2.844E-04	1.460E-03	AR, FLT3, DAPK1, HIF1A, TP53
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	1.367E-04	8.099E-04	FLT3, TP53, HIF1A
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.249E-04	8.017E-04	CYP2C9, CYP1A2, CYP1A1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.042E-06	2.375E-05	CA12, CA2, CA7
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.493E-04	8.209E-04	CYP2C9, CYP1A2, CYP2C19
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.720E-03	8.277E-03	DAPK1, TP53
09130 Environmental Information Processing	09131 Membrane transport	hsa02010	ABC transporters	1.979E-03	8.962E-03	ABCC1, ABCG2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.169E-05	1.757E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Melanoma	C43	TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
NA: NA	HIV infections	NA	AHR;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases