CMAUP Plant Collective Molecular Activities

Plant Name: Sophora viciifolia

Taxonomic Information:

Plant ID: NPO26788
Plant Latin Name: Sophora viciifolia
Taxonomy Genus: Sophora
Taxonomy Family: Fabaceae

Plant External Links:

NCBI TaxonomyDB: 1196212
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	ALOX15; TNKS; TNKS2;
Oxidoreductase	PTGS2;
Lysine demethylase	KDM4E;
Unclassified	FABP3; FABP4; LMNA; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP19A1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	TNKS	Tankyrase-1	O95271	CHEMBL6164
Enzyme_unclassified	TNKS2	Tankyrase-2	Q9H2K2	CHEMBL6154
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Oxidoreductase	PTGS2	Cyclooxygenase-2	P35354	CHEMBL230
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005504; fatty acid binding	4.088E-09	8.902E-05	FABP3, FABP4, FABP5, FFAR4
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	8.625E-07	1.501E-03	FABP3, FABP4, FABP5
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	6.647E-07	1.501E-03	CYP19A1, CYP1A1, CYP1B1
MF	GO:0003824; catalytic activity	GO:0050473; arachidonate 15-lipoxygenase activity	1.688E-06	1.934E-03	ALOX15, PTGS2
MF	GO:0005488; binding	GO:0020037; heme binding	2.373E-06	2.461E-03	CYP19A1, CYP1A1, CYP1B1, PTGS2
BP	GO:0008152; metabolic process	GO:0070213; protein auto-ADP-ribosylation	3.374E-06	3.194E-03	TNKS, TNKS2
BP	GO:0009987; cellular process	GO:0071248; cellular response to metal ion	4.230E-06	3.684E-03	ALOX15, CYP1A1, FABP4, PTGS2
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.272E-06	3.958E-03	CYP19A1, CYP1A1, CYP1B1
MF	GO:0005488; binding	GO:0005506; iron ion binding	5.764E-06	4.184E-03	ALOX15, CYP19A1, CYP1A1, CYP1B1

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	4.622E-08	1.479E-06	CYP1A1, CYP1B1, PTGS2, CYP19A1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	1.721E-07	2.753E-06	FABP3, FABP4, FABP5, PPARA
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.027E-05	1.096E-04	CYP1A1, CYP1B1, CYP19A1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	2.917E-05	2.334E-04	CYP1A1, CYP1B1, PTGS2
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.028E-04	2.578E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	7.898E-04	4.212E-03	FABP4, PTGS2
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	9.673E-04	4.422E-03	ALOX15, PTGS2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.338E-03	5.352E-03	CYP1A1, CYP1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Ankylosing spondylitis	M08.1, M45	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	PTGS2;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	PTGS2;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	PTGS2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Chronic pain	R52.1-R52.2, G89	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Knee osteoarthritis	M15-M19, M47	PTGS2;
C00-D49: Neoplasms	Pancreatic cancer	C25	PTGS2;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
K00-K95: Diseases of the digestive system	Colon polyps	K63.5	PTGS2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Hyperthermia	T68	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Gout	M10	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Moderate to severe rheumatoid arthritis	M05-M06	PTGS2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	PTGS2;
J00-J99: Diseases of the respiratory system	Asthma	J45	PTGS2;
C00-D49: Neoplasms	Cancer	C00-C96	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	PTGS2;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
NA: NA	Joint and muscular pain	NA	PTGS2;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	PTGS2;
NA: NA	Rheumatold arthritis	NA	PTGS2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	PTGS2;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	PTGS2; CYP19A1;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	PTGS2;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTGS2; FFAR1;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases