CMAUP Plant Collective Molecular Activities

Plant Name: Pteris multifida

Taxonomic Information:

Plant ID: NPO26770
Plant Latin Name: Pteris multifida
Taxonomy Genus: Pteris
Taxonomy Family: Pteridaceae

Plant External Links:

NCBI TaxonomyDB: 170715
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

Indian Folk; TCM

Geographical Distribution:

India; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1;
Lyase	CA12;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.581E-03	1.000E+00	CA12
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	6.819E-03	1.000E+00	CA12
BP	GO:0002376; immune system process	GO:0030097; hemopoiesis	1.376E-02	1.000E+00	L3MBTL1
BP	GO:0009987; cellular process	GO:0006302; double-strand break repair	2.633E-02	1.000E+00	TDP1
BP	GO:0009987; cellular process	GO:1901796; regulation of signal transduction by p53 class mediator	2.709E-02	1.000E+00	L3MBTL1
CC	GO:0016020; membrane	GO:0005886; plasma membrane	1.183E-02	1.000E+00	CA12, L3MBTL1, TDP1
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.328E-03	1.000E+00	CA12
MF	GO:0005488; binding	GO:0008270; zinc ion binding	5.160E-03	1.000E+00	CA12, L3MBTL1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.548E-03	2.548E-03	CA12

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases