Plant Name: Pedicularis semitorta
Taxonomic Information:
Plant ID: NPO2671
Plant Latin Name: Pedicularis semitorta
Taxonomy Genus: Pedicularis
Taxonomy Family: Orobanchaceae
Plant External Links:
NCBI TaxonomyDB:
326846
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TSHR; | |
| HTR6; | |
| TDP1; RECQL; MTOR; | |
| ODC1; | |
| MT-ND4; | |
| TP53; | |
| MAPT; PMP22; GMNN; LMNA; | |
| SMN1;SMN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2D6 | Cytochrome P450 2D6 | P10635 | CHEMBL289 |
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | MTOR | Serine/threonine-protein kinase mTOR | P42345 | CHEMBL2842 |
| Lyase | ODC1 | Ornithine decarboxylase | P11926 | CHEMBL1869 |
| Methyl-lysine/arginine binding protein | SMN1;SMN2 | Survival motor neuron protein | Q16637 | CHEMBL1293232 |
| Oxidoreductase | MT-ND4 | NADH-ubiquinone oxidoreductase chain 4 | P03905 | CHEMBL4499 |
| Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
| Small molecule receptor (family A GPCR) | HTR6 | Serotonin 6 (5-HT6) receptor | P50406 | CHEMBL3371 |
| Transcription Factor | TP53 | Cellular tumor antigen p53 | P04637 | CHEMBL4096 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | PMP22 | Peripheral myelin protein 22 | Q01453 | CHEMBL1293298 |
| Unclassified | GMNN | Geminin | O75496 | CHEMBL1293278 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 8.428E-06 | 1.835E-01 | CYP2C19, CYP2D6 |
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 2.020E-05 | 1.861E-01 | RECQL, TP53 |
| BP | GO:0009987; cellular process | GO:1901216; positive regulation of neuron death | 2.677E-05 | 1.861E-01 | MAPT, MTOR, TP53 |
| BP | GO:0008152; metabolic process | GO:2000379; positive regulation of reactive oxygen species metabolic process | 4.274E-05 | 1.861E-01 | MAPT, MTOR, TP53 |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 6.582E-05 | 2.389E-01 | LMNA, MTOR, TP53 |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 2.103E-04 | 3.570E-01 | MAPT, TP53 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 3.113E-04 | 3.570E-01 | CYP2C19, CYP2D6 |
| MF | GO:0005488; binding | GO:0019825; oxygen binding | 5.466E-04 | 3.570E-01 | CYP2C19, CYP2D6 |
| MF | GO:0060089; molecular transducer activity | GO:0004996; thyroid-stimulating hormone receptor activity | 1.553E-03 | 5.046E-01 | TSHR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 9.078E-05 | 6.264E-03 | HTR6, CYP2D6, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05214 | Glioma | 1.212E-03 | 2.354E-02 | TP53, MTOR |
| 09160 Human Diseases | 09161 Cancers | hsa05230 | Central carbon metabolism in cancer | 1.287E-03 | 2.354E-02 | TP53, MTOR |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.364E-03 | 2.354E-02 | CYP2D6, CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05215 | Prostate cancer | 2.256E-03 | 2.889E-02 | TP53, MTOR |
| 09150 Organismal Systems | 09149 Aging | hsa04211 | Longevity regulating pathway - mammal | 2.513E-03 | 2.889E-02 | TP53, MTOR |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 3.924E-03 | 3.868E-02 | TP53, MTOR |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04210 | Apoptosis | 5.475E-03 | 4.722E-02 | LMNA, TP53 |
| 09120 Genetic Information Processing | 09122 Translation | hsa03013 | RNA transport | 8.152E-03 | 6.250E-02 | SMN2, SMN1 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 1.120E-02 | 7.027E-02 | TP53, MTOR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| A00-B99: Certain infectious and parasitic diseases | Malaria | B54 | CYP2D6; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | HTR6; |
| C00-D49: Neoplasms | Bladder cancer | C67 | MTOR; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MTOR; |
| G00-G99: Diseases of the nervous system G00-G99 | Migraine | G43 | CYP2D6; |
| I00-I99: Diseases of the circulatory system | Neurological disease | I21, I22, R52, R52.1-R52.2, R60.9, G89 | HTR6; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | HTR6; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Transplant rejection | D89.8, T86 | MTOR; |
| G00-G99: Diseases of the nervous system G00-G99 | Spinal muscular atrophy | G00-G99 | SMN1;SMN2; |
| C00-D49: Neoplasms | Solid tumors | NA | MTOR; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | HTR6; |
| C00-D49: Neoplasms | Non-hodgkin's lymphoma | C85 | MTOR; |
| C00-D49: Neoplasms | Non-small cell lung cancer | C33-C34 | MTOR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CYP2D6; |
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MTOR; |
| C00-D49: Neoplasms | Inflammatory disease | C11, C44, K75.9, M00-M25 | MTOR; |
| C00-D49: Neoplasms | Lymphoma | C81-C86 | MTOR; |
| R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified | Emesis | R11 | HTR6; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Schizophrenia | F20 | HTR6; |
| C00-D49: Neoplasms | Advanced kidney cancer | C64 | MTOR; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | MTOR; |
| C00-D49: Neoplasms | Pancreatic cancer | C25 | MTOR; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | HTR6; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Dementia | F01-F07 | HTR6; |
| D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism | Organ rejection | D89.8, T86 | MTOR; |
| C00-D49: Neoplasms | Multiple myeloma | C90 | MTOR; |
| NA: NA | Coronary artery restenosis | NA | MTOR; |
| A00-B99: Certain infectious and parasitic diseases | Dutch elm disease | B81-B83 | MTOR; |
| C00-D49: Neoplasms | Renal cancer | C64 | MTOR; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | HTR6; |
| C00-D49: Neoplasms | Sarcoma | C81-C86 | MTOR; |
| I00-I99: Diseases of the circulatory system | Restenosis | I51.89 | MTOR; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MTOR; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
