CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALDH1A1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2A6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0032501; multicellular organismal process	GO:0055015; ventricular cardiac muscle cell development	1.552E-03	1.000E+00	LMNA
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	1.863E-03	1.000E+00	CYP2A6
BP	GO:0008152; metabolic process	GO:0006069; ethanol oxidation	1.863E-03	1.000E+00	ALDH1A1
BP	GO:0009987; cellular process	GO:0090201; negative regulation of release of cytochrome c from mitochondria	2.638E-03	1.000E+00	LMNA
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	3.258E-03	1.000E+00	CYP2A6
BP	GO:0008152; metabolic process	GO:0042572; retinol metabolic process	4.652E-03	1.000E+00	ALDH1A1
BP	GO:0009987; cellular process	GO:0007077; mitotic nuclear envelope disassembly	6.819E-03	1.000E+00	LMNA
BP	GO:0009987; cellular process	GO:2001237; negative regulation of extrinsic apoptotic signaling pathway	1.591E-02	1.000E+00	LMNA
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	1.607E-02	1.000E+00	LMNA
BP	GO:0051179; localization	GO:1900180; regulation of protein localization to nucleus	3.393E-02	1.000E+00	LMNA

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.114E-05	3.425E-04	CYP2A6, ALDH1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	6.884E-03	1.478E-02	CYP2A6
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	7.498E-04	4.124E-03	CYP2A6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.031E-02	1.478E-02	CYP2A6
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.091E-02	1.478E-02	CYP2A6
09160 Human Diseases	09165 Cardiovascular diseases	hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	1.106E-02	1.478E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05414	Dilated cardiomyopathy	1.344E-02	1.478E-02	LMNA
09160 Human Diseases	09165 Cardiovascular diseases	hsa05410	Hypertrophic cardiomyopathy (HCM)	1.240E-02	1.478E-02	LMNA
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.225E-02	1.478E-02	CYP2A6
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.103E-02	1.478E-02	CYP2A6, ALDH1A1

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
No data available in table

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Conocephalum conicum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities