Plant Name: Conocephalum conicum
Taxonomic Information:
Plant ID: NPO26657
Plant Latin Name: Conocephalum conicum
Taxonomy Genus: Conocephalum
Taxonomy Family: Conocephalaceae
Plant External Links:
NCBI TaxonomyDB:
41839
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2A6; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2A6 | Cytochrome P450 2A6 | P11509 | CHEMBL5282 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0055015; ventricular cardiac muscle cell development | 1.552E-03 | 1.000E+00 | LMNA |
| BP | GO:0050896; response to stimulus | GO:0042738; exogenous drug catabolic process | 1.863E-03 | 1.000E+00 | CYP2A6 |
| BP | GO:0008152; metabolic process | GO:0006069; ethanol oxidation | 1.863E-03 | 1.000E+00 | ALDH1A1 |
| BP | GO:0009987; cellular process | GO:0090201; negative regulation of release of cytochrome c from mitochondria | 2.638E-03 | 1.000E+00 | LMNA |
| BP | GO:0008152; metabolic process | GO:0019373; epoxygenase P450 pathway | 3.258E-03 | 1.000E+00 | CYP2A6 |
| BP | GO:0008152; metabolic process | GO:0042572; retinol metabolic process | 4.652E-03 | 1.000E+00 | ALDH1A1 |
| BP | GO:0009987; cellular process | GO:0007077; mitotic nuclear envelope disassembly | 6.819E-03 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:2001237; negative regulation of extrinsic apoptotic signaling pathway | 1.591E-02 | 1.000E+00 | LMNA |
| BP | GO:0009987; cellular process | GO:0071456; cellular response to hypoxia | 1.607E-02 | 1.000E+00 | LMNA |
| BP | GO:0051179; localization | GO:1900180; regulation of protein localization to nucleus | 3.393E-02 | 1.000E+00 | LMNA |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 3.788E-02 | 1.000E+00 | CYP2A6 |
| MF | GO:0003824; catalytic activity | GO:0008389; coumarin 7-hydroxylase activity | 3.106E-04 | 1.000E+00 | CYP2A6 |
| MF | GO:0005488; binding | GO:0005497; androgen binding | 6.212E-04 | 1.000E+00 | ALDH1A1 |
| MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 1.087E-03 | 1.000E+00 | ALDH1A1 |
| MF | GO:0003824; catalytic activity | GO:0008392; arachidonic acid epoxygenase activity | 2.638E-03 | 1.000E+00 | CYP2A6 |
| MF | GO:0003824; catalytic activity | GO:0016712; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | 4.033E-03 | 1.000E+00 | CYP2A6 |
| MF | GO:0003824; catalytic activity | GO:0008395; steroid hydroxylase activity | 5.272E-03 | 1.000E+00 | CYP2A6 |
| MF | GO:0005488; binding | GO:0051287; NAD binding | 9.136E-03 | 1.000E+00 | ALDH1A1 |
| MF | GO:0005488; binding | GO:0020037; heme binding | 1.975E-02 | 1.000E+00 | CYP2A6 |
| MF | GO:0005488; binding | GO:0005506; iron ion binding | 2.465E-02 | 1.000E+00 | CYP2A6 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 3.114E-05 | 3.425E-04 | CYP2A6, ALDH1A1 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00983 | Drug metabolism - other enzymes | 6.884E-03 | 1.478E-02 | CYP2A6 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.103E-02 | 1.478E-02 | CYP2A6, ALDH1A1 |
| 09100 Metabolism | 09110 Biosynthesis of other secondary metabolites | hsa00232 | Caffeine metabolism | 7.498E-04 | 4.124E-03 | CYP2A6 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.031E-02 | 1.478E-02 | CYP2A6 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.091E-02 | 1.478E-02 | CYP2A6 |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 1.106E-02 | 1.478E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05414 | Dilated cardiomyopathy | 1.344E-02 | 1.478E-02 | LMNA |
| 09160 Human Diseases | 09165 Cardiovascular diseases | hsa05410 | Hypertrophic cardiomyopathy (HCM) | 1.240E-02 | 1.478E-02 | LMNA |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.225E-02 | 1.478E-02 | CYP2A6 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
