CMAUP Plant Collective Molecular Activities

Plant Name: Cichorium endivia

Taxonomic Information:

Plant ID: NPO26643
Plant Latin Name: Cichorium endivia
Taxonomy Genus: Cichorium
Taxonomy Family: Asteraceae

Plant External Links:

NCBI TaxonomyDB: 114280
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Italy; India

Traditional Medicine System:

Geographical Distribution:

Italy; India

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0097677; STAT family protein binding	3.106E-04	3.560E-01	PTPN2
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	4.142E-04	3.921E-01	PTPN2
MF	GO:0005488; binding	GO:0030971; receptor tyrosine kinase binding	2.899E-03	9.018E-01	PTPN2
CC	GO:0044464; cell part	GO:0005783; endoplasmic reticulum	4.887E-02	1.000E+00	PTPN2
MF	GO:0003824; catalytic activity	GO:0016791; phosphatase activity	1.408E-02	1.000E+00	PTPN2
MF	GO:0005488; binding	GO:0019901; protein kinase binding	2.992E-02	1.000E+00	PTPN2
MF	Unclassified;	GO:0032403; protein complex binding	4.116E-02	1.000E+00	PTPN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	7.900E-03	7.900E-03	PTPN2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases