CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2C19;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Showing 1 to 4 of 4 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	4.823E-07	1.050E-02	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.447E-06	1.540E-02	CYP1A2, CYP2C19
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	2.121E-06	1.540E-02	CYP1A2, CYP2C19
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	6.746E-06	3.672E-02	CYP1A2, CYP2C19
CC	GO:0016020; membrane	GO:0031090; organelle membrane	9.939E-03	1.000E+00	CYP1A2, CYP2C19, LMNA
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.278E-02	1.000E+00	CYP1A2, CYP2C19
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	3.333E-02	1.000E+00	LMNA
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	3.797E-02	1.000E+00	TSHR
MF	GO:0005488; binding	GO:0019825; oxygen binding	3.175E-05	1.383E-01	CYP1A2, CYP2C19
MF	GO:0003824; catalytic activity	GO:0004497; monooxygenase activity	1.427E-04	2.652E-01	CYP1A2, CYP2C19

Showing 1 to 10 of 15 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
No data available in table

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Daphne tangutica

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities