CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	ALPL; HSD17B10;
Hydrolase	GAA;
Lyase	CA2; CA5B; CA6; CA12; CA1; CA5A;
Transcription Factor	NFKB1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.043E-14	1.483E-10	CA1, CA12, CA2, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.644E-15	6.145E-11	CA1, CA12, CA2, CA5A, CA5B, CA6
MF	GO:0005488; binding	GO:0008270; zinc ion binding	9.914E-07	2.159E-03	CA1, CA12, CA2, CA5A, CA5B, CA6
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	3.614E-06	7.155E-03	CA1, CA2
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.456E-17	3.170E-13	CA1, CA12, CA2, CA5A, CA5B, CA6

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.921E-17	1.898E-15	CA12, CA1, CA5B, CA2, CA5A, CA6
09130 Environmental Information Processing	09132 Signal transduction	hsa04668	TNF signaling pathway	5.367E-02	8.721E-02	NFKB1
09150 Organismal Systems	09155 Excretory system	hsa04966	Collecting duct acid secretion	1.342E-02	8.721E-02	CA2
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	3.543E-02	8.721E-02	NFKB1
09150 Organismal Systems	09151 Immune system	hsa04622	RIG-I-like receptor signaling pathway	3.446E-02	8.721E-02	NFKB1
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	3.495E-02	8.721E-02	CA2
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	3.591E-02	8.721E-02	NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05142	Chagas disease (American trypanosomiasis)	5.081E-02	8.721E-02	NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	5.319E-02	8.721E-02	NFKB1
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.049E-02	8.721E-02	GAA, ALPL, HSD17B10

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	Cancer	C00-C96	NFKB1;
C00-D49: Neoplasms	Colon cancer	C50	ALPL;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	NFKB1;
Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities	Genetic disease	Q00-Q99	ALPL;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Sesamoides canescens

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities