CMAUP Plant Collective Molecular Activities

Plant Name: Tinospora smilacina

Taxonomic Information:

Plant ID: NPO26487
Plant Latin Name: Tinospora smilacina
Taxonomy Genus: Tinospora
Taxonomy Family: Menispermaceae

Plant External Links:

NCBI TaxonomyDB: 461643
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Australia

Traditional Medicine System:

Geographical Distribution:

Australia

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; OPRD1; NMUR2;
Small molecule receptor (family A GPCR)	ADRA2C; ADRA2A;
Hydrolase	GAA; ACHE;
Enzyme_unclassified	TDP1; POLB;
Protein Kinase	MAPK1; KIT; KDR; AURKB; AURKA;
ATP-binding cassette	ABCC1;
Unclassified	LMNA; RAB9A; NPC1;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	OPRD1	Delta opioid receptor	P41143	CHEMBL236
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	KIT	Stem cell growth factor receptor	P10721	CHEMBL1936
Protein Kinase	KDR	Vascular endothelial growth factor receptor 2	P35968	CHEMBL279
Protein Kinase	AURKB	Serine/threonine-protein kinase Aurora-B	Q96GD4	CHEMBL2185
Protein Kinase	AURKA	Serine/threonine-protein kinase Aurora-A	O14965	CHEMBL4722
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	1.332E-08	1.221E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.760E-07	7.665E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0019825; oxygen binding	2.203E-07	7.995E-04	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0046686; response to cadmium ion	5.384E-07	1.172E-03	CYP1A2, KIT, MAPK1, NPC1
BP	GO:0032501; multicellular organismal process	GO:0006940; regulation of smooth muscle contraction	9.854E-07	1.533E-03	ADRA2A, ADRA2C, KIT, NMUR2
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.934E-06	2.340E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	2.571E-06	2.947E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	4.066E-06	4.119E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0071310; cellular response to organic substance	5.654E-06	4.767E-03	ADRA2A, CYP1A1, CYP1B1, KDR, KIT, MAPK1, NPC1, OPRD1, TSHR
BP	GO:0050896; response to stimulus	GO:0009636; response to toxic substance	5.854E-06	4.767E-03	CYP1A1, CYP1B1, KDR, MAPK1, OPRD1, POLB
BP	GO:0065007; biological regulation	GO:0035625; epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway	8.126E-06	5.204E-03	ADRA2A, ADRA2C
BP	GO:0009987; cellular process	GO:0032811; negative regulation of epinephrine secretion	8.126E-06	5.204E-03	ADRA2A, ADRA2C
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	8.126E-06	5.204E-03	CYP1A1, CYP1A2
BP	GO:0032501; multicellular organismal process	GO:0051930; regulation of sensory perception of pain	8.614E-06	5.210E-03	ADRA2C, NMUR2, OPRD1
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	9.152E-06	5.386E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1, NPC1
CC	GO:0032991; macromolecular complex	GO:0032133; chromosome passenger complex	1.353E-05	7.367E-03	AURKA, AURKB
MF	GO:0005488; binding	GO:0020037; heme binding	1.477E-05	7.847E-03	CYP19A1, CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0042493; response to drug	1.643E-05	8.318E-03	ABCC1, CYP1A1, CYP1B1, KDR, MAPK1, NPC1, POLB
MF	GO:0003824; catalytic activity	GO:0004712; protein serine/threonine/tyrosine kinase activity	1.642E-05	8.318E-03	AURKA, AURKB, MAPK1
MF	GO:0003824; catalytic activity	GO:0035174; histone serine kinase activity	2.028E-05	9.602E-03	AURKA, AURKB
CC	GO:0043226; organelle	GO:0005876; spindle microtubule	3.323E-05	1.292E-02	AURKA, AURKB, POLB
CC	GO:0043226; organelle	GO:0000780; condensed nuclear chromosome, centromeric region	8.887E-05	2.304E-02	AURKA, AURKB
CC	GO:0043226; organelle	GO:0031616; spindle pole centrosome	8.887E-05	2.304E-02	AURKA, AURKB
CC	GO:0016020; membrane	GO:0005886; plasma membrane	9.699E-05	2.485E-02	ABCC1, ACHE, ADRA2A, ADRA2C, GAA, KDR, KIT, L3MBTL1, MAPK1, NMUR2, OPRD1, RAB9A, TDP1, TSHR

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	5.410E-07	6.222E-05	CYP1A2, CYP1A1, CYP1B1, CYP19A1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.277E-05	5.168E-04	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.348E-05	5.168E-04	OPRD1, NMUR2, ADRA2C, ADRA2A, TSHR
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.514E-05	7.226E-04	CYP1A1, CYP1B1, CYP19A1
09130 Environmental Information Processing	09132 Signal transduction	hsa04022	cGMP-PKG signaling pathway	3.668E-05	8.437E-04	OPRD1, MAPK1, ADRA2C, ADRA2A
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.840E-05	1.503E-03	CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.109E-04	1.822E-03	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	3.417E-04	4.913E-03	OPRD1, ABCC1, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04015	Rap1 signaling pathway	1.754E-03	2.129E-02	KIT, KDR, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	2.161E-03	2.129E-02	KIT, KDR, MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Advanced malignancies	C00-C96	KDR;
C00-D49: Neoplasms	Advanced renal cell carcinoma	C64	KDR;
C00-D49: Neoplasms	Biliary cancer	C22, C24	KDR;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	KDR;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	KDR;
C00-D49: Neoplasms	Myelodysplastic syndrome	D46	KDR;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Haematological malignancies	C81-C86	AURKA;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	AURKA; AURKB;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	KDR;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
C00-D49: Neoplasms	Pancreatic cancer	C25	KDR;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Ovarian cancer	C56	KDR;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	AURKB;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	KDR;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
C00-D49: Neoplasms	Cutaneous Melanoma	C43-C44	KDR;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	AURKA;
C00-D49: Neoplasms	Liver cancer	C22	KDR;
C00-D49: Neoplasms	Advanced solid tumor	C00-C75, C7A, C7B	AURKA;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Melanoma	C43	KDR;
C00-D49: Neoplasms	Medullary thyroid cancer	C73	KDR;
C00-D49: Neoplasms	Metastatic castration-resistant prostate cancer	C61	KDR;
C00-D49: Neoplasms	Fallopian tube cancer	C57.0, D28.2	KDR;
C00-D49: Neoplasms	Thyroid cancer	C73	KDR; TSHR;
C00-D49: Neoplasms	Metastatic colorectal cancer	C18-C21	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
C00-D49: Neoplasms	Peritoneal cavity cancer	NA	KDR;
C00-D49: Neoplasms	Solid tumours	C00-D48	AURKA; AURKB; KDR;
C00-D49: Neoplasms	Gastric cancer	C16	KDR;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
C00-D49: Neoplasms	Non-small-cell lung cancer	NA	KDR;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
C00-D49: Neoplasms	Renal cancer	C64	KDR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
C00-D49: Neoplasms	Metastatic breast cancer	C50	KDR;
C00-D49: Neoplasms	Renal cell carcinoma	NA	KDR;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Cancer	C00-C96	AURKA; KDR; ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
C00-D49: Neoplasms	Breast cancer	C50	KDR; CYP19A1;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
C00-D49: Neoplasms	Squamous cell cancer of head and neck	NA	KDR;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
I00-I99: Diseases of the circulatory system	Angiogenesis disorder	I00-I99	KDR;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
C00-D49: Neoplasms	AML	NA	KDR;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
NA: NA	Upper abdominal bloating	NA	ACHE;
C00-D49: Neoplasms	Glioma	C71	KDR;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Gastrointestinal cancers	C15-C26	KDR;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases