Plant ID: NPO26465
Plant Latin Name: Coreopsis tinctoria
Taxonomy Genus: Coreopsis
Taxonomy Family: Asteraceae
NCBI TaxonomyDB:
41554
Plant-of-the-World-Online:
n.a.
Unknown.
TSHR; | |
TDP1; BLM; ALOX15; HSD17B10; POLB; | |
PIM1; CSNK2A1; | |
ESR1; ESR2; | |
ELANE; | |
HIF1A; | |
MAPT; APP; LMNA; | |
L3MBTL1; |
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 2 | CYP2C9 | Cytochrome P450 2C9 | P11712 | CHEMBL3397 |
Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | BLM | Bloom syndrome protein | P54132 | CHEMBL1293237 |
Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
Nuclear hormone receptor subfamily 3 group A | ESR1 | Estrogen receptor alpha | P03372 | CHEMBL206 |
Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
Protein Kinase | CSNK2A1 | Casein kinase II alpha | P68400 | CHEMBL3629 |
Serine protease | ELANE | Leukocyte elastase | P08246 | CHEMBL248 |
Transcription Factor | HIF1A | Hypoxia-inducible factor 1 alpha | Q16665 | CHEMBL4261 |
Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Unclassified | APP | Beta amyloid A4 protein | P05067 | CHEMBL2487 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0005488; binding | GO:0046914; transition metal ion binding | 1.478E-07 | 3.219E-03 | ALOX15, APP, BLM, CYP2C9, CYP3A4, ESR1, ESR2, L3MBTL1, PIM1 |
BP | GO:0040007; growth | GO:0040008; regulation of growth | 1.135E-06 | 8.239E-03 | APP, CSNK2A1, ELANE, ESR2, HIF1A, MAPT, PIM1 |
MF | GO:0060089; molecular transducer activity | GO:0038052; RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding | 8.202E-07 | 8.239E-03 | ESR1, ESR2 |
MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 3.314E-06 | 1.529E-02 | CSNK2A1, HIF1A, MAPT |
MF | GO:0005488; binding | GO:0034056; estrogen response element binding | 4.916E-06 | 1.529E-02 | ESR1, ESR2 |
MF | GO:0003824; catalytic activity | GO:0034875; caffeine oxidase activity | 4.916E-06 | 1.529E-02 | CYP2C9, CYP3A4 |
BP | GO:0009987; cellular process | GO:0008088; axo-dendritic transport | 9.408E-06 | 2.276E-02 | APP, HIF1A, MAPT |
BP | GO:0008152; metabolic process | GO:0016098; monoterpenoid metabolic process | 1.228E-05 | 2.673E-02 | CYP2C9, CYP3A4 |
BP | GO:0009987; cellular process | GO:0009966; regulation of signal transduction | 1.828E-05 | 3.326E-02 | ALOX15, APP, BLM, CSNK2A1, ELANE, ESR1, ESR2, HIF1A, L3MBTL1, LMNA, MAPT |
BP | GO:0050896; response to stimulus | GO:0010033; response to organic substance | 2.734E-05 | 3.558E-02 | ALOX15, APP, BLM, CSNK2A1, ELANE, ESR1, HIF1A, POLB, TSHR |
CC | GO:0043226; organelle | GO:0043229; intracellular organelle | 4.790E-05 | 4.342E-02 | ALOX15, APP, BLM, CSNK2A1, CYP2C9, CYP3A4, ELANE, ESR1, ESR2, HIF1A, HSD17B10, L3MBTL1, LMNA, MAPT, PIM1, POLB, TDP1 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 2.204E-06 | 1.168E-04 | CYP2C9, ALOX15, CYP3A4 |
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.312E-04 | 3.477E-03 | CYP2C9, APP, ALOX15 |
09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 4.330E-04 | 7.649E-03 | APP, MAPT, HSD17B10 |
09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.401E-03 | 1.283E-02 | CYP2C9, ALOX15 |
09150 Organismal Systems | 09152 Endocrine system | hsa04917 | Prolactin signaling pathway | 1.884E-03 | 1.283E-02 | ESR1, ESR2 |
09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.539E-03 | 1.283E-02 | CYP2C9, CYP3A4 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.732E-03 | 1.283E-02 | CYP2C9, CYP3A4 |
09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00980 | Metabolism of xenobiotics by cytochrome P450 | 1.936E-03 | 1.283E-02 | CYP2C9, CYP3A4 |
09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 3.524E-03 | 1.868E-02 | ESR1, ESR2 |
09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 2.435E-03 | 1.434E-02 | CYP2C9, CYP3A4 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|