CMAUP Plant Collective Molecular Activities

Plant Name: Sorghum bicolor

Taxonomic Information:

Plant ID: NPO26371
Plant Latin Name: Sorghum bicolor
Taxonomy Genus: Sorghum
Taxonomy Family: Poaceae

Plant External Links:

NCBI TaxonomyDB: 4558
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Madagascar; Italy; South Africa; Tanzania; Jordan; India; United States; Zimbabwe; Rwanda; Angola; Swaziland; Kenya

Traditional Medicine System:

Indian Folk; Unani; Ayurveda; Siddha

Medicinal Functions:

Astringent; Demulcent; Diuretic; Haemostatic

Geographical Distribution:

Madagascar; Italy; South Africa; Tanzania; India; Zimbabwe; United States; Rwanda; Jordan; Swaziland; Kenya; Angola

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Kinase	FYN; LCK; MAPK1; MAPK14;
Lyase	CA2; CA1; CA12; CA9; CA7; CA14;
Oxidoreductase	ALOX5;
Methyl-lysine/arginine binding protein	L3MBTL1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	TBXAS1; CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 5	TBXAS1	Thromboxane-A synthase	P24557	CHEMBL1835
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Methyl-lysine/arginine binding protein	L3MBTL1	Lethal(3)malignant brain tumor-like protein 1	Q9Y468	CHEMBL1287622
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Protein Kinase	FYN	Tyrosine-protein kinase FYN	P06241	CHEMBL1841
Protein Kinase	LCK	Tyrosine-protein kinase LCK	P06239	CHEMBL258
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Kinase	MAPK14	MAP kinase p38 alpha	Q16539	CHEMBL260

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	2.901E-13	3.159E-09	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.330E-11	1.450E-07	CA1, CA12, CA2, CA7, CA9
MF	GO:0005488; binding	GO:0042610; CD8 receptor binding	4.878E-07	9.657E-04	FYN, LCK
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.463E-06	2.124E-03	CA2, CA7
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	7.305E-06	8.372E-03	CA1, CA2
MF	GO:0005488; binding	GO:0042608; T cell receptor binding	1.022E-05	9.275E-03	FYN, LCK
MF	GO:0005488; binding	GO:0042609; CD4 receptor binding	1.022E-05	9.275E-03	FYN, LCK
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.078E-16	4.526E-12	CA1, CA12, CA14, CA2, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.168E-16	4.835E-14	CA12, CA1, CA2, CA7, CA9, CA14
09150 Organismal Systems	09151 Immune system	hsa04660	T cell receptor signaling pathway	6.635E-07	3.848E-05	LCK, MAPK1, FYN, MAPK14
09150 Organismal Systems	09151 Immune system	hsa04611	Platelet activation	1.258E-06	4.865E-05	TBXAS1, MAPK1, FYN, MAPK14
09150 Organismal Systems	09158 Development	hsa04380	Osteoclast differentiation	1.724E-06	5.000E-05	LCK, MAPK1, FYN, MAPK14
09150 Organismal Systems	09151 Immune system	hsa04664	Fc epsilon RI signaling pathway	1.332E-05	3.091E-04	MAPK1, FYN, MAPK14
09160 Human Diseases	09167 Infectious diseases	hsa05145	Toxoplasmosis	6.950E-05	1.211E-03	ALOX5, MAPK1, MAPK14
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	7.306E-05	1.211E-03	MAPK1, FYN, MAPK14
09150 Organismal Systems	09151 Immune system	hsa04650	Natural killer cell mediated cytotoxicity	1.037E-04	1.503E-03	LCK, MAPK1, FYN
09130 Environmental Information Processing	09132 Signal transduction	hsa04370	VEGF signaling pathway	8.133E-04	8.120E-03	MAPK1, MAPK14
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05020	Prion diseases	2.672E-04	3.444E-03	MAPK1, FYN
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	8.400E-04	8.120E-03	ALOX5, TBXAS1
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	7.104E-04	8.120E-03	MAPK1, MAPK14
09150 Organismal Systems	09152 Endocrine system	hsa04917	Prolactin signaling pathway	1.131E-03	8.368E-03	MAPK1, MAPK14
09160 Human Diseases	09167 Infectious diseases	hsa05140	Leishmaniasis	1.162E-03	8.368E-03	MAPK1, MAPK14
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.194E-03	8.368E-03	MAPK1, FYN
09160 Human Diseases	09167 Infectious diseases	hsa05131	Shigellosis	9.229E-04	8.235E-03	MAPK1, MAPK14
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	1.226E-03	8.368E-03	MAPK1, MAPK14

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	LCK;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5;
I00-I99: Diseases of the circulatory system	Coronary artery disease	I20-I25	MAPK14;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	MAPK14; ALOX5;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	TBXAS1; ALOX5;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	MAPK14; TBXAS1;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
H00-H59: Diseases of the eye and adnexa	Diabetic retinopathy	H36, E10.3, E11.3, E13.3	MAPK14;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	CA1;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
J00-J99: Diseases of the respiratory system	Asthma	J45	TBXAS1; ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	MAPK14; ALOX5;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5;
J00-J99: Diseases of the respiratory system	Acute lung injury	J80	MAPK14;
NA: NA	Rheumatold arthritis	NA	MAPK14;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2; CA1;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CA1;
N00-N99: Diseases of the genitourinary system	Nephritis	N00-N19, N25-N29	TBXAS1;
NA: NA	Edema	NA	CA2;
I00-I99: Diseases of the circulatory system	Acute coronary syndrome	I74	MAPK14;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	TBXAS1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5;
NA: NA	Inflammatory diseases	NA	MAPK14;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	MAPK14; ALOX5;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; MAPK14; CA1; CA9;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	TBXAS1;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	MAPK14; ALOX5;
I00-I99: Diseases of the circulatory system	Thromboembolism	I80-I82	TBXAS1;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
NA: NA	Acute respiratory distress syndrome	NA	MAPK14;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	TBXAS1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; CA9;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	MAPK14; ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases