Plant ID: NPO26343
Plant Latin Name: Fagopyrum esculentum
Taxonomy Genus: Fagopyrum
Taxonomy Family: Polygonaceae
NCBI TaxonomyDB:
3617
Plant-of-the-World-Online:
n.a.
Acrid; Astringent; Galactogogue; Vasodilator
Madagascar; Angola; South Africa; Tanzania; India; Zimbabwe; Rwanda; China; Swaziland; Thailand; Kenya; South Korea
TSHR; | |
FFAR1; FFAR4; | |
PTPN1; | |
TDP1; PKM; ALOX15; ALDH1A1; APEX1; POLB; | |
ACHE; | |
CA2; CA12; CA1; CA9; CA14; CA3; CA5B; CA5A; CA6; CA7; | |
PPARA; PPARG; | |
ESR2; | |
NR1I2; | |
PTGS1; | |
SLCO1B3; SLCO1B1; | |
LMNA; MCL1; MAPT; THPO; |
Cytochrome P450 Enzymes: | CYP3A4; |
---|
Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cytochrome P450 family 3 | CYP3A4 | Cytochrome P450 3A4 | P08684 | CHEMBL340 |
Enzyme_unclassified | APEX1 | DNA-(apurinic or apyrimidinic site) lyase | P27695 | CHEMBL5619 |
Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
Enzyme_unclassified | PKM | Pyruvate kinase isozymes M1/M2 | P14618 | CHEMBL1075189 |
Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
Lyase | CA9 | Carbonic anhydrase IX | Q16790 | CHEMBL3594 |
Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
Lyase | CA3 | Carbonic anhydrase III | P07451 | CHEMBL2885 |
Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
Lyase | CA7 | Carbonic anhydrase VII | P43166 | CHEMBL2326 |
Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
Nuclear hormone receptor subfamily 1 group C | PPARG | Peroxisome proliferator-activated receptor gamma | P37231 | CHEMBL235 |
Nuclear hormone receptor subfamily 1 group I | NR1I2 | Pregnane X receptor | O75469 | CHEMBL3401 |
Nuclear hormone receptor subfamily 3 group A | ESR2 | Estrogen receptor beta | Q92731 | CHEMBL242 |
Oxidoreductase | PTGS1 | Cyclooxygenase-1 | P23219 | CHEMBL221 |
Peptide receptor (family A GPCR) | TSHR | Thyroid stimulating hormone receptor | P16473 | CHEMBL1963 |
Protein Phosphatase | PTPN1 | Protein-tyrosine phosphatase 1B | P18031 | CHEMBL335 |
SLC superfamily of solute carriers | SLCO1B3 | Solute carrier organic anion transporter family member 1B3 | Q9NPD5 | CHEMBL1743121 |
SLC superfamily of solute carriers | SLCO1B1 | Solute carrier organic anion transporter family member 1B1 | Q9Y6L6 | CHEMBL1697668 |
Small molecule receptor (family A GPCR) | FFAR1 | Free fatty acid receptor 1 | O14842 | CHEMBL4422 |
Small molecule receptor (family A GPCR) | FFAR4 | G-protein coupled receptor 120 | Q5NUL3 | CHEMBL5339 |
Unclassified | MCL1 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Q07820 | CHEMBL4361 |
Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Unclassified | THPO | Thrombopoietin | P40225 | CHEMBL1293256 |
Unclassified | LMNA | Prelamin-A/C | P02545 | CHEMBL1293235 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.906E-11 | 4.150E-08 | CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9, ESR2, NR1I2, PPARA, PPARG, PTPN1 |
MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 1.391E-25 | 3.028E-21 | CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9 |
MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.416E-06 | 1.542E-03 | ESR2, NR1I2, PPARA, PPARG |
BP | GO:0009987; cellular process | GO:0006286; base-excision repair, base-free sugar-phosphate removal | 2.830E-06 | 2.935E-03 | APEX1, POLB |
MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 3.006E-06 | 2.976E-03 | ESR2, NR1I2, PPARA, PPARG |
BP | GO:0009987; cellular process | GO:0032849; positive regulation of cellular pH reduction | 8.482E-06 | 7.104E-03 | CA2, CA7 |
BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.114E-19 | 8.082E-16 | CA1, CA12, CA14, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9 |
BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 3.421E-18 | 1.490E-14 | CA1, CA12, CA2, CA3, CA5A, CA5B, CA6, CA7, CA9 |
CC | GO:0016020; membrane | GO:0016323; basolateral plasma membrane | 1.496E-05 | 1.051E-02 | CA2, CA9, SLCO1B1, SLCO1B3, TSHR |
MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 4.228E-05 | 2.192E-02 | CA1, CA2 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 6.347E-25 | 3.999E-23 | CA12, CA1, CA3, CA5B, CA2, CA5A, CA7, CA6, CA9, CA14 |
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 5.519E-06 | 1.739E-04 | SLCO1B1, CA2, SLCO1B3, CYP3A4 |
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 1.042E-03 | 2.126E-02 | ALOX15, CYP3A4 |
09150 Organismal Systems | 09152 Endocrine system | hsa04923 | Regulation of lipolysis in adipocytes | 3.846E-03 | 4.552E-02 | TSHR, PTGS1 |
09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 1.350E-03 | 2.126E-02 | POLB, APEX1 |
09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 4.693E-03 | 4.552E-02 | ALOX15, PTGS1 |
09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 5.146E-03 | 4.552E-02 | ALDH1A1, CYP3A4 |
09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 5.780E-03 | 4.552E-02 | PPARG, PPARA |
09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 1.392E-02 | 8.393E-02 | PTPN1, PPARA |
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.466E-02 | 8.393E-02 | ALOX15, PTGS1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
---|---|---|---|
F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | CYP3A4; |