Plant ID: NPO26300
Plant Latin Name: Penianthus zenkeri
Taxonomy Genus: Penianthus
Taxonomy Family: Menispermaceae
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
NR1H4; | |
HSD17B10; HPGD; ALDH1A1; | |
CASP7; CASP1; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
MF | GO:0003824; catalytic activity | GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis | 6.262E-06 | 1.049E-01 | CASP1, CASP7 |
BP | GO:0009987; cellular process | GO:0097194; execution phase of apoptosis | 5.625E-05 | 2.416E-01 | CASP1, CASP7 |
BP | GO:0050896; response to stimulus | GO:0032496; response to lipopolysaccharide | 5.651E-05 | 2.416E-01 | CASP1, HPGD, NR1H4 |
BP | GO:0009987; cellular process | GO:0010803; regulation of tumor necrosis factor-mediated signaling pathway | 1.365E-04 | 2.416E-01 | CASP1, NR1H4 |
BP | GO:0008152; metabolic process | GO:0006629; lipid metabolic process | 2.075E-04 | 2.416E-01 | ALDH1A1, HPGD, HSD17B10, NR1H4 |
BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 2.641E-04 | 2.416E-01 | CASP1, CASP7 |
MF | GO:0005488; binding | GO:0051287; NAD binding | 1.365E-04 | 2.416E-01 | ALDH1A1, HPGD |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 1.106E-04 | 1.649E-03 | CASP7, CASP1 |
09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 2.061E-04 | 1.649E-03 | CASP7, CASP1 |
09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 1.029E-03 | 5.488E-03 | CASP7, HSD17B10 |
09100 Metabolism | 09105 Amino acid metabolism | hsa00280 | Valine, leucine and isoleucine degradation | 1.432E-02 | 3.754E-02 | HSD17B10 |
09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 1.520E-02 | 3.754E-02 | CASP1 |
09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 1.698E-02 | 3.754E-02 | CASP1 |
09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 1.934E-02 | 3.754E-02 | ALDH1A1 |
09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 1.905E-02 | 3.754E-02 | CASP1 |
09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.111E-02 | 3.754E-02 | NR1H4 |
09160 Human Diseases | 09167 Infectious diseases | hsa05132 | Salmonella infection | 2.553E-02 | 4.084E-02 | CASP1 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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