CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Protein Phosphatase	CDC25B;
Enzyme_unclassified	RECQL; ALPL; BLM; ALOX12; HSD17B2; HSD17B10; NOX4; POLB;
Hydrolase	ATP12A; ACHE;
Protein Kinase	AURKB; MET; AXL; FLT3; CDK1; PIM1; KDR; IGF1R;
Lyase	CA2; CA12; CA7;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Oxidoreductase	TYR;
Transcription Factor	AHR; NFKB1;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4; CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	ALPL	Alkaline phosphatase, tissue-nonspecific isozyme	P05186	CHEMBL5979
Enzyme_unclassified	BLM	Bloom syndrome protein	P54132	CHEMBL1293237
Enzyme_unclassified	ALOX12	Arachidonate 12-lipoxygenase	P18054	CHEMBL3687
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159

Showing 1 to 10 of 34 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	1.320E-07	1.306E-04	ALPL, BLM, CYP1A1, CYP1B1, FLT3, NFKB1, NOX4, RORC
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	5.929E-07	4.303E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0010035; response to inorganic substance	1.060E-06	6.236E-04	AXL, BLM, CA2, CDK1, CYP1A1, CYP1A2, CYP1B1, KDR
BP	GO:0009987; cellular process	GO:0043066; negative regulation of apoptotic process	1.392E-06	7.775E-04	ALOX12, AURKB, AXL, CDK1, IGF1R, KDR, LMNA, NFKB1, NR1H4, PIM1
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	6.485E-06	2.615E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0050896; response to stimulus	GO:0032496; response to lipopolysaccharide	7.907E-06	3.074E-03	ALPL, AXL, CYP1A1, CYP1A2, NFKB1, NR1H4
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	8.614E-06	3.115E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	9.012E-06	3.115E-03	CA2, CA7
BP	GO:0008152; metabolic process	GO:0018108; peptidyl-tyrosine phosphorylation	1.740E-05	4.901E-03	AXL, FLT3, IGF1R, KDR, MET
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.800E-05	4.901E-03	CYP1A1, CYP1A2

Showing 1 to 10 of 27 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	4.487E-08	5.249E-06	CYP1A2, HSD17B2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	6.972E-06	2.039E-04	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.248E-05	8.284E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.003E-06	1.171E-04	CA12, CA2, CA7
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.824E-04	2.372E-03	CYP1A2, CYP1A1, CYP3A4
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.107E-03	8.631E-03	CYP1A2, CYP3A4
09130 Environmental Information Processing	09132 Signal transduction	hsa04014	Ras signaling pathway	5.737E-04	5.503E-03	KDR, MET, NFKB1, IGF1R
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.516E-06	8.871E-05	HSD17B2, CYP1A1, CYP1B1, IGF1R
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.371E-04	2.535E-03	CA2, NR1H4, CYP3A4
09150 Organismal Systems	09152 Endocrine system	hsa04914	Progesterone-mediated oocyte maturation	6.114E-04	5.503E-03	CDK1, CDC25B, IGF1R

Showing 1 to 10 of 15 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Human immunodeficiency virus infection	B20-B26	FLT3;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Anthelmintic	B89	ALPL;
C00-D49: Neoplasms	CLL	NA	FLT3;
C00-D49: Neoplasms	Prostate cancer	C61	FLT3;
C00-D49: Neoplasms	Liver cancer	C22	IGF1R; KDR;
C00-D49: Neoplasms	Leukemia	C90-C95	FLT3;
C00-D49: Neoplasms	Colon cancer	C50	FLT3; ALPL;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	IGF1R; KDR; FLT3;

Showing 1 to 10 of 100 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Isodon japonicus

Taxonomic Information:

Plant External Links:

Used in Medicines:

Country/Region:

Traditional Medicine System:

Medicinal Functions:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities