Plant Name: Helenium autumnale
Taxonomic Information:
Plant ID: NPO26233
Plant Latin Name: Helenium autumnale
Taxonomy Genus: Helenium
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
138408
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Unknown.
Geographical Distribution:
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PIM1; | |
| GFER; | |
| NPC1; MAPT; RAB9A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | GFER | FAD-linked sulfhydryl oxidase ALR | P55789 | CHEMBL1741189 |
| Protein Kinase | PIM1 | Serine/threonine-protein kinase PIM1 | P11309 | CHEMBL2147 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0032501; multicellular organismal process | GO:0048699; generation of neurons | 2.069E-03 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:1990000; amyloid fibril formation | 2.069E-03 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:0019896; axonal transport of mitochondrion | 2.328E-03 | 1.000E+00 | MAPT |
| BP | GO:0032501; multicellular organismal process | GO:0048143; astrocyte activation | 2.328E-03 | 1.000E+00 | MAPT |
| BP | GO:0008152; metabolic process | GO:0032930; positive regulation of superoxide anion generation | 3.619E-03 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:0071404; cellular response to low-density lipoprotein particle stimulus | 3.619E-03 | 1.000E+00 | NPC1 |
| BP | Unclassified; | GO:2000188; regulation of cholesterol homeostasis | 3.619E-03 | 1.000E+00 | NPC1 |
| BP | GO:0002376; immune system process | GO:0001774; microglial cell activation | 4.393E-03 | 1.000E+00 | MAPT |
| BP | GO:0051179; localization | GO:0033344; cholesterol efflux | 6.198E-03 | 1.000E+00 | NPC1 |
| BP | GO:0007610; behavior | GO:0007628; adult walking behavior | 6.970E-03 | 1.000E+00 | NPC1 |
| BP | GO:0050896; response to stimulus | GO:0046686; response to cadmium ion | 1.441E-02 | 1.000E+00 | NPC1 |
| BP | GO:0065007; biological regulation | GO:0042632; cholesterol homeostasis | 1.697E-02 | 1.000E+00 | NPC1 |
| BP | GO:0009987; cellular process | GO:0071383; cellular response to steroid hormone stimulus | 1.901E-02 | 1.000E+00 | NPC1 |
| BP | GO:0009987; cellular process | GO:1901216; positive regulation of neuron death | 1.978E-02 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:1900034; regulation of cellular response to heat | 2.003E-02 | 1.000E+00 | MAPT |
| BP | GO:0065007; biological regulation | GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process | 2.105E-02 | 1.000E+00 | MAPT |
| BP | GO:0009987; cellular process | GO:0060548; negative regulation of cell death | 2.205E-02 | 1.000E+00 | NPC1, PIM1 |
| BP | GO:0032501; multicellular organismal process | GO:0001889; liver development | 2.689E-02 | 1.000E+00 | GFER |
| BP | GO:0007610; behavior | GO:0007613; memory | 2.689E-02 | 1.000E+00 | MAPT |
| BP | GO:0065007; biological regulation | GO:0043433; negative regulation of DNA binding transcription factor activity | 3.597E-02 | 1.000E+00 | PIM1 |
| BP | GO:0009987; cellular process | GO:0050808; synapse organization | 3.648E-02 | 1.000E+00 | MAPT |
| BP | GO:0051179; localization | GO:0045184; establishment of protein localization | 4.102E-02 | 1.000E+00 | NPC1, RAB9A |
| BP | GO:0009987; cellular process | GO:2001020; regulation of response to DNA damage stimulus | 4.549E-02 | 1.000E+00 | MAPT |
| BP | GO:0008152; metabolic process | GO:0046777; protein autophosphorylation | 4.972E-02 | 1.000E+00 | PIM1 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 1.949E-03 | 1.000E+00 | NPC1, RAB9A |
| CC | GO:0044464; cell part | GO:0030673; axolemma | 4.135E-03 | 1.000E+00 | MAPT |
| CC | GO:0044464; cell part | GO:0005829; cytosol | 1.573E-02 | 1.000E+00 | GFER, MAPT, PIM1, RAB9A |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 1.723E-02 | 1.000E+00 | MAPT |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 2.587E-02 | 1.000E+00 | RAB9A |
| CC | GO:0044464; cell part | GO:0005635; nuclear envelope | 4.149E-02 | 1.000E+00 | NPC1 |
| CC | GO:0044464; cell part | GO:0036464; cytoplasmic ribonucleoprotein granule | 4.698E-02 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 2.844E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0034185; apolipoprotein binding | 4.135E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0051721; protein phosphatase 2A binding | 7.228E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0051879; Hsp90 protein binding | 8.257E-03 | 1.000E+00 | MAPT |
| MF | GO:0005488; binding | GO:0050660; flavin adenine dinucleotide binding | 1.901E-02 | 1.000E+00 | GFER |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05221 | Acute myeloid leukemia | 1.417E-02 | 5.507E-02 | PIM1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.500E-02 | 5.507E-02 | PIM1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 3.354E-02 | 5.507E-02 | RAB9A |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 3.038E-02 | 5.507E-02 | NPC1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 3.888E-02 | 5.507E-02 | PIM1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 4.130E-02 | 5.507E-02 | MAPT |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04010 | MAPK signaling pathway | 6.215E-02 | 7.103E-02 | MAPT |
| 09160 Human Diseases | 09161 Cancers | hsa05206 | MicroRNAs in cancer | 7.208E-02 | 7.208E-02 | PIM1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | MAPT; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | MAPT; |
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | MAPT; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
