CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	HTR1A;
Protein Phosphatase	PTPN1;
Hydrolase	BCHE; GAA; ACHE;
Transcription Factor	HIF1A;
Enzyme_unclassified	POLB;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP2D6;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	BCHE	Butyrylcholinesterase	P06276	CHEMBL1914
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Small molecule receptor (family A GPCR)	HTR1A	Serotonin 1a (5-HT1a) receptor	P08908	CHEMBL214
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	4.803E-09	1.046E-04	BCHE, CYP1A2, CYP2D6
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	4.417E-06	1.924E-02	CYP1A2, CYP2D6
BP	GO:0008152; metabolic process	GO:0042133; neurotransmitter metabolic process	1.468E-05	4.568E-02	ACHE, BCHE, HTR1A
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	1.940E-05	4.693E-02	CYP1A2, CYP2D6
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.940E-05	4.693E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	2.292E-05	4.991E-02	SMN1, SMN2
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	2.948E-07	3.210E-03	ACHE, BCHE
MF	GO:0005488; binding	GO:0042165; neurotransmitter binding	2.990E-06	1.628E-02	ACHE, BCHE, HTR1A

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	6.323E-04	1.167E-02	CYP2D6, CYP1A2
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	7.075E-04	1.167E-02	CYP2D6, CYP1A2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.584E-02	7.427E-02	CYP1A2
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	3.038E-02	7.975E-02	GAA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.638E-02	7.427E-02	GAA
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.747E-03	2.266E-02	CYP1A2
09120 Genetic Information Processing	09122 Translation	hsa03013	RNA transport	3.843E-03	2.537E-02	SMN2, SMN1
09120 Genetic Information Processing	09124 Replication and repair	hsa03410	Base excision repair	1.801E-02	7.427E-02	POLB
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.654E-03	1.819E-02	CYP2D6, HTR1A
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.625E-02	7.975E-02	HIF1A

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;

Showing 1 to 10 of 22 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Phymatopteris hastata

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities