CMAUP Plant Collective Molecular Activities

Plant Name: Curcuma wenyujin

Taxonomic Information:

Plant ID: NPO2618
Plant Latin Name: Curcuma wenyujin
Taxonomy Genus: Curcuma
Taxonomy Family: Zingiberaceae

Plant External Links:

NCBI TaxonomyDB: 136221
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4;
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	PTGES; ALOX15;
Protein Kinase	MAPK1;
Lyase	CA2;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Oxidoreductase	ALOX5; MAOA;
Transcription Factor	TP53;
Unclassified	FABP3; LMNA; F3; FABP4; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP19A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 19	CYP19A1	Cytochrome P450 19A1	P11511	CHEMBL1978
Enzyme_unclassified	PTGES	Prostaglandin E synthase	O14684	CHEMBL5658
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Oxidoreductase	ALOX5	Arachidonate 5-lipoxygenase	P09917	CHEMBL215
Oxidoreductase	MAOA	Monoamine oxidase A	P21397	CHEMBL1951
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	F3	Coagulation factor III	P13726	CHEMBL4081
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0005504; fatty acid binding	9.139E-09	1.990E-04	FABP3, FABP4, FABP5, FFAR4
BP	GO:0050896; response to stimulus	GO:0010038; response to metal ion	3.040E-07	1.252E-03	ALOX15, CA2, FABP4, MAPK1, PTGES, TP53
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	1.543E-06	4.199E-03	FABP3, FABP4, FABP5
BP	GO:0008152; metabolic process	GO:0046456; icosanoid biosynthetic process	5.176E-06	8.628E-03	ALOX15, ALOX5, PTGES

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.827E-07	5.128E-05	FABP3, FABP4, FABP5, PPARA
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	2.684E-06	1.798E-04	MAOA, ALOX5, ALOX15, MAPK1
09100 Metabolism	09103 Lipid metabolism	hsa00590	Arachidonic acid metabolism	2.239E-05	1.000E-03	ALOX5, ALOX15, PTGES
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.536E-04	6.797E-03	LMNA, MAPK1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	2.181E-04	6.797E-03	MAPK1, PPARA, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	3.062E-04	6.838E-03	MAPK1, TP53

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
L00-L99: Diseases of the skin and subcutaneous tissue	Pruritus	L29	ALOX5;
N00-N99: Diseases of the genitourinary system	Prostate disease	N42.9	CYP19A1;
J00-J99: Diseases of the respiratory system	Adult respiratory distress syndrome	J80	F3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	NPSR1;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	MAOA;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; TP53;
I00-I99: Diseases of the circulatory system	Atherosclerosis	I70	ALOX5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Arthritis	M00-M25	ALOX5;
J00-J99: Diseases of the respiratory system	Asthma	J45	ALOX5;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	ALOX5;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Osteoarthritis	M15-M19, M47	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Atopic dermatitis	L00-L99	ALOX5;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Depression	F30-F39	MAOA;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
L00-L99: Diseases of the skin and subcutaneous tissue	Dermatitis	L20-L30	ALOX5;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
C00-D49: Neoplasms	Hormonally-responsive breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
J00-J99: Diseases of the respiratory system	Rhinitis	J00, J30, J31.0	ALOX5;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
N00-N99: Diseases of the genitourinary system	Endometriosis	N80	CYP19A1;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
L00-L99: Diseases of the skin and subcutaneous tissue	Psoriasis	L40	ALOX5;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	MAOA;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mood disorder	F30-F39	MAOA;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	ALOX5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	MAOA;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ALOX5;
A00-B99: Certain infectious and parasitic diseases	Lymphatic filariasis	B74	ALOX5;
C00-D49: Neoplasms	Breast cancer	C50	CYP19A1;
C00-D49: Neoplasms	Advanced breast cancer	C50	CYP19A1;
NA: NA	Edema	NA	CA2;
C00-D49: Neoplasms	Bladder cancer	C67	CYP19A1;
I00-I99: Diseases of the circulatory system	Bleeding	I74, I80-I82	F3;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Pancreatic cancer	C25	F3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	MAOA;
I00-I99: Diseases of the circulatory system	Thrombosis	I80-I82	ALOX5;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ALOX5;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; TP53;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	ALOX5;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	MAOA;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	MAOA;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAOA; PTGES;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ALOX5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	MAOA;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases