CMAUP Plant Collective Molecular Activities

Plant Name: Anisodus tanguticus

Taxonomic Information:

Plant ID: NPO26163
Plant Latin Name: Anisodus tanguticus
Taxonomy Genus: Anisodus
Taxonomy Family: Solanaceae

Plant External Links:

NCBI TaxonomyDB: 243964
Plant-of-the-World-Online: 814269-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Nepal; China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	CHRM1; CHRM2; CHRM3; CHRM5;
Lyase	CA2; CA14; CA7; CA12;
Oxidoreductase	TYR;
Enzyme_unclassified	HSD17B2;
Transcription Factor	AHR;
Unclassified	LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP2A6; CYP1A1; CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Enzyme_unclassified	HSD17B2	Estradiol 17-beta-dehydrogenase 2	P37059	CHEMBL2789
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Oxidoreductase	TYR	Tyrosinase	P14679	CHEMBL1973
Small molecule receptor (family A GPCR)	CHRM1	Muscarinic acetylcholine receptor M1	P11229	CHEMBL216
Small molecule receptor (family A GPCR)	CHRM2	Muscarinic acetylcholine receptor M2	P08172	CHEMBL211
Small molecule receptor (family A GPCR)	CHRM3	Muscarinic acetylcholine receptor M3	P20309	CHEMBL245
Small molecule receptor (family A GPCR)	CHRM5	Muscarinic acetylcholine receptor M5	P08912	CHEMBL2035
Transcription Factor	AHR	Aryl hydrocarbon receptor	P35869	CHEMBL3201
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	1.569E-12	1.708E-08	CHRM1, CHRM2, CHRM3, CHRM5
MF	GO:0060089; molecular transducer activity	GO:0016907; G-protein coupled acetylcholine receptor activity	1.569E-12	1.708E-08	CHRM1, CHRM2, CHRM3, CHRM5
BP	GO:0050896; response to stimulus	GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	4.703E-12	3.414E-08	CHRM1, CHRM2, CHRM3, CHRM5
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.261E-10	1.952E-06	CA12, CA14, CA2, CA7
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.863E-09	5.070E-06	CYP1A1, CYP1A2, CYP1B1, CYP2A6
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	5.446E-09	9.882E-06	CHRM1, CHRM2, CHRM3, CHRM5
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	4.177E-08	6.063E-05	CA12, CA14, CA2, CA7
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	5.576E-08	7.588E-05	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	8.175E-07	6.847E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	8.175E-07	6.847E-04	CYP1A1, CYP1A2, CYP1B1
MF	GO:0003824; catalytic activity	GO:0004435; phosphatidylinositol phospholipase C activity	1.347E-06	9.344E-04	CHRM1, CHRM3, CHRM5
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	1.929E-06	1.199E-03	CA2, CA7
MF	GO:0005488; binding	GO:0020037; heme binding	3.148E-06	1.853E-03	CYP1A1, CYP1A2, CYP1B1, CYP2A6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.274E-06	1.876E-03	CA12, CA2, CA7
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	3.856E-06	2.099E-03	CYP1A1, CYP1A2
BP	GO:0032502; developmental process	GO:0048856; anatomical structure development	5.217E-06	2.705E-03	AHR, CA2, CHRM1, CHRM2, CHRM3, CYP1A1, CYP1A2, CYP1B1, HSD17B2, LMNA, TYR
BP	GO:0032501; multicellular organismal process	GO:0046541; saliva secretion	6.423E-06	3.206E-03	CHRM1, CHRM3
MF	GO:0005488; binding	GO:0019825; oxygen binding	6.478E-06	3.206E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0005488; binding	GO:0005506; iron ion binding	7.636E-06	3.538E-03	CYP1A1, CYP1A2, CYP1B1, CYP2A6
CC	GO:0044456; synapse part	GO:0043679; axon terminus	1.192E-05	5.406E-03	CHRM1, CHRM2, CHRM3
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	1.348E-05	5.643E-03	CYP1A1, CYP2A6
BP	GO:0008152; metabolic process	GO:0050665; hydrogen peroxide biosynthetic process	1.796E-05	7.110E-03	CYP1A1, CYP1A2
CC	GO:0045202; synapse	GO:0032279; asymmetric synapse	1.796E-05	7.110E-03	CHRM2, CHRM3
BP	Unclassified;	GO:0003056; regulation of vascular smooth muscle contraction	2.308E-05	8.518E-03	CHRM1, CHRM3
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	2.272E-05	8.518E-03	CHRM1, CHRM2, CHRM3, CHRM5

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.459E-10	2.131E-08	CA12, CA2, CA7, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.129E-07	1.863E-06	CYP1A2, HSD17B2, CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.875E-07	3.163E-06	CYP2A6, CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	1.553E-06	1.025E-05	CHRM2, CHRM3, CHRM1, CHRM5
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	4.601E-07	3.796E-06	CYP2A6, CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	4.076E-06	2.242E-05	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	1.061E-05	3.891E-05	CHRM2, CHRM3, CHRM1, CHRM5
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	8.047E-06	3.319E-05	HSD17B2, CYP1A1, CYP1B1
09140 Cellular Processes	09142 Cell motility	hsa04810	Regulation of actin cytoskeleton	2.097E-05	6.291E-05	CHRM2, CHRM3, CHRM1, CHRM5
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	1.780E-05	5.875E-05	CYP2A6, CYP1A2, CYP1A1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5.747E-05	1.580E-04	CHRM2, CHRM3, CHRM1, CHRM5
09150 Organismal Systems	09154 Digestive system	hsa04971	Gastric acid secretion	1.567E-03	3.694E-03	CHRM3, CA2
Unclassified	Unclassified	hsa01100	Metabolic pathways	2.223E-03	4.891E-03	CYP2A6, HSD17B2, CYP1A2, CYP1A1, TYR
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	1.364E-03	3.463E-03	CYP2A6, CYP1A2
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	2.619E-03	5.401E-03	CHRM3, CA2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	5.992E-06	2.825E-05	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	TYR;
NA: NA	Addiction	NA	CHRM2;
G00-G99: Diseases of the nervous system G00-G99	Brain diseases	G00-G99	CHRM5;
NA: NA	Spasms	NA	CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CHRM3;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRM1; CHRM5;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	CHRM1; CHRM5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Sjogren's syndrome	M35.0	CHRM3;
NA: NA	Schizoaffective disorders	NA	CHRM1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CA2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CHRM1; CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	CHRM5;
L00-L99: Diseases of the skin and subcutaneous tissue	Vitiligo	L80	TYR;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Visceral spasms	R25.2	CHRM1;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CHRM1;
C00-D49: Neoplasms	Multiple myeloma	C90	AHR;
C00-D49: Neoplasms	Melanoma	C43	TYR;
L00-L99: Diseases of the skin and subcutaneous tissue	Melasma	L81.1	TYR;
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	CHRM5;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	CHRM2;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	CHRM1; CHRM2; CHRM3; CHRM5;
J00-J99: Diseases of the respiratory system	Obstructive lung diseases	J40-J44, J47	CHRM3;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	CHRM1; CHRM3; CHRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	CHRM1; CHRM5;
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	CHRM1; CHRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRM1;
K00-K95: Diseases of the digestive system	Colitis	K50-K52	CHRM5;
I00-I99: Diseases of the circulatory system	Heart failure	I50	CHRM2;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	CHRM1; CHRM2;
N00-N99: Diseases of the genitourinary system	Overactive bladder	N32.81	CHRM3;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	CHRM1; CHRM3;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnosing bronchial hyperreactivity	W88	CHRM3;
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	CHRM2;
J00-J99: Diseases of the respiratory system	Asthma	J45	CHRM2;
I00-I99: Diseases of the circulatory system	Edema associated with congestive heart failure	I50, R60.9	CA2;
NA: NA	Edema	NA	CA2;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	CHRM5;
NA: NA	Dystonia	NA	CHRM1;
K00-K95: Diseases of the digestive system	Duodenal ulcers	K25-K27	CA2;
NA: NA	Extrapyramidal disorders secondary to neuroleptic drug therapy	NA	CHRM1;
NA: NA	Excessive sweating	NA	CHRM1;
NA: NA	Abdominal stomach pain	NA	CHRM1;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	CA2;
NA: NA	Functional bowel syndrome	NA	CHRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Postoperative nausea and vomiting	R11	CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	CHRM1; CHRM2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Stabilize muscle contractions	M00-M99	CHRM2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	CHRM1; CHRM2; CHRM3;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	CHRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Amnesia	F04	CHRM5;
NA: NA	HIV infections	NA	AHR;
I00-I99: Diseases of the circulatory system	High blood pressure	I10-I16	CA2;
L00-L99: Diseases of the skin and subcutaneous tissue	Seborrhea	L21	CHRM3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRM1; CHRM5;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases