CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Hydrolase	ACHE;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
CC	GO:0044464; cell part	GO:0009986; cell surface	2.806E-02	1.000E+00	ACHE
CC	GO:0044464; cell part	GO:0048471; perinuclear region of cytoplasm	3.350E-02	1.000E+00	ACHE
MF	GO:0003824; catalytic activity	GO:0003990; acetylcholinesterase activity	1.035E-04	4.509E-01	ACHE
MF	GO:0005488; binding	GO:0042562; hormone binding	4.400E-03	1.000E+00	ACHE
MF	GO:0005488; binding	GO:0042277; peptide binding	1.387E-02	1.000E+00	ACHE
MF	GO:0003824; catalytic activity	GO:0017171; serine hydrolase activity	1.465E-02	1.000E+00	ACHE
MF	Unclassified;	GO:0032403; protein complex binding	4.116E-02	1.000E+00	ACHE

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09103 Lipid metabolism	hsa00564	Glycerophospholipid metabolism	4.750E-03	5.550E-03	ACHE
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	5.550E-03	5.550E-03	ACHE

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Buxus natalensis

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities