Plant Name: Isodon serra
Taxonomic Information:
Plant ID: NPO26123
Plant Latin Name: Isodon serra
Taxonomy Genus: Isodon
Taxonomy Family: Lamiaceae
Plant External Links:
NCBI TaxonomyDB:
199544
Plant-of-the-World-Online:
448614-1
Used in Medicines:
Unknown.
Geographical Distribution:
Taiwan; China; Russia; South Africa
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| MMP12; MMP2; MMP9; | |
| POLB; | |
| RAB9A; NPC1; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Metallo protease | MMP12 | Matrix metalloproteinase 12 | P39900 | CHEMBL4393 |
| Metallo protease | MMP2 | Matrix metalloproteinase-2 | P08253 | CHEMBL333 |
| Metallo protease | MMP9 | Matrix metalloproteinase 9 | P14780 | CHEMBL321 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0030574; collagen catabolic process | 7.222E-07 | 7.351E-03 | MMP12, MMP2, MMP9 |
| BP | GO:0009987; cellular process | GO:0022617; extracellular matrix disassembly | 1.305E-06 | 7.351E-03 | MMP12, MMP2, MMP9 |
| BP | Unclassified; | GO:0044259; multicellular organismal macromolecule metabolic process | 1.688E-06 | 7.351E-03 | MMP12, MMP2, MMP9 |
| BP | Unclassified; | GO:0044236; multicellular organism metabolic process | 3.174E-06 | 1.152E-02 | MMP12, MMP2, MMP9 |
| MF | GO:0003824; catalytic activity | GO:0004222; metalloendopeptidase activity | 4.058E-06 | 1.262E-02 | MMP12, MMP2, MMP9 |
| BP | GO:0008283; cell proliferation | GO:1904707; positive regulation of vascular smooth muscle cell proliferation | 1.852E-05 | 4.482E-02 | MMP2, MMP9 |
| MF | GO:0003824; catalytic activity | GO:0004252; serine-type endopeptidase activity | 4.064E-05 | 8.045E-02 | MMP12, MMP2, MMP9 |
| BP | GO:0022414; reproductive process | GO:0007566; embryo implantation | 5.625E-05 | 8.198E-02 | MMP2, MMP9 |
| CC | GO:0044421; extracellular region part | GO:0005578; proteinaceous extracellular matrix | 5.835E-05 | 8.198E-02 | MMP12, MMP2, MMP9 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 1.350E-03 | 7.738E-01 | MMP12, MMP2, MMP9 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 2.896E-03 | 9.702E-01 | NPC1, RAB9A |
| CC | GO:0043226; organelle | GO:0043231; intracellular membrane-bounded organelle | 4.289E-02 | 1.000E+00 | MMP12, MMP2, NPC1, POLB, RAB9A |
| CC | GO:0044421; extracellular region part | GO:0070062; extracellular exosome | 4.364E-02 | 1.000E+00 | MMP9, NPC1, RAB9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09161 Cancers | hsa05219 | Bladder cancer | 6.118E-05 | 9.789E-04 | MMP2, MMP9 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04915 | Estrogen signaling pathway | 3.592E-04 | 2.719E-03 | MMP2, MMP9 |
| 09150 Organismal Systems | 09151 Immune system | hsa04670 | Leukocyte transendothelial migration | 5.098E-04 | 2.719E-03 | MMP2, MMP9 |
| 09160 Human Diseases | 09161 Cancers | hsa05205 | Proteoglycans in cancer | 1.497E-03 | 5.988E-03 | MMP2, MMP9 |
| 09160 Human Diseases | 09161 Cancers | hsa05200 | Pathways in cancer | 5.592E-03 | 1.789E-02 | MMP2, MMP9 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 2.992E-02 | 5.735E-02 | MMP2 |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 9.860E-03 | 2.629E-02 | POLB |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05161 | Hepatitis B | 4.301E-02 | 5.735E-02 | MMP9 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 4.012E-02 | 5.735E-02 | RAB9A |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 3.634E-02 | 5.735E-02 | NPC1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| K00-K95: Diseases of the digestive system | Ulcerative colitis | K51 | MMP9; |
| C00-D49: Neoplasms | Solid tumours | C00-D48 | MMP9; |
| C00-D49: Neoplasms | Colorectal cancer | C18-C21 | MMP9; |
| I00-I99: Diseases of the circulatory system | Stroke | I61-I63, I80-I82 | MMP9; |
| C00-D49: Neoplasms | Cancer | C00-C96 | MMP9; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
