CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1; FFAR1;
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1; PTPN2; PTPN11; PTPN6; CDC25B;
Enzyme_unclassified	PLA2G1B; CES1; TDP1; PTGES; TERT; AKR1B10; AKR1B1; CES2; POLB;
Hydrolase	GAA; ACHE;
Lyase	CA2; CA1; CA12; CA9; CA14; CA7; CA4; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD; PPARG;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Transcription Factor	STAT3;
Unclassified	APAF1; MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	CES1	Acyl coenzyme A:cholesterol acyltransferase	P23141	CHEMBL2265
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	PTGES	Prostaglandin E synthase	O14684	CHEMBL5658
Enzyme_unclassified	TERT	Telomerase reverse transcriptase	O14746	CHEMBL2916
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	CES2	Carboxylesterase 2	O00748	CHEMBL3180
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	2.180E-13	7.910E-10	CA1, CA12, CA2, CA4, CA6, CA7, CA9
BP	GO:0065007; biological regulation	GO:0042593; glucose homeostasis	3.146E-07	2.864E-04	FFAR1, NR1H4, PPARG, PTPN11, PTPN2, STAT3
BP	GO:0008152; metabolic process	GO:0006631; fatty acid metabolic process	6.975E-07	4.340E-04	CES1, CES2, PLA2G1B, PPARA, PPARD, PPARG, PTGES
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	7.899E-07	4.778E-04	CDC25B, PTPN1, PTPN11, PTPN2, PTPN6
BP	GO:0009987; cellular process	GO:0060338; regulation of type I interferon-mediated signaling pathway	1.239E-06	6.916E-04	PTPN1, PTPN11, PTPN2, PTPN6
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	1.661E-06	8.413E-04	NR1H4, PPARA, PPARD, PPARG, PTPN2
BP	GO:0009987; cellular process	GO:0033277; abortive mitotic cell cycle	3.007E-06	1.364E-03	PTPN11, PTPN6
BP	GO:0051179; localization	GO:0015908; fatty acid transport	5.668E-06	2.204E-03	PLA2G1B, PPARA, PPARD, PPARG
BP	GO:0009987; cellular process	GO:0033554; cellular response to stress	6.174E-06	2.318E-03	AKR1B1, APAF1, CA2, CA9, MAPT, POLB, PPARD, PPARG, PTPN1, PTPN11, TDP1, TERT
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	9.012E-06	3.102E-03	CA2, CA7

Showing 1 to 10 of 23 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	6.889E-19	5.925E-17	CA12, CA1, CA2, CA4, CA7, CA6, CA9, CA14
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.766E-05	7.594E-04	AKR1B10, GAA, AKR1B1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00040	Pentose and glucuronate interconversions	1.704E-03	1.629E-02	AKR1B10, AKR1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	2.770E-03	2.383E-02	CES2, CES1
09100 Metabolism	09101 Carbohydrate metabolism	hsa00051	Fructose and mannose metabolism	1.348E-03	1.449E-02	AKR1B10, AKR1B1
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	1.446E-04	3.108E-03	STAT3, PTPN6, PTPN11, PTPN2
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	2.273E-04	3.258E-03	STAT3, PTPN11, PPARA
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.178E-04	3.258E-03	PPARG, PPARA, PPARD
09150 Organismal Systems	09155 Excretory system	hsa04964	Proximal tubule bicarbonate reclamation	6.940E-04	8.526E-03	CA2, CA4
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	3.413E-05	9.783E-04	PTPN1, STAT3, PTPN11, PPARA

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; CDC25B;
C00-D49: Neoplasms	Acute lymphoblastic leukemia	C91.0	CES1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PPARD;
E00-E89: Endocrine, nutritional and metabolic diseases	Dyslipidaemias	E78	PPARD;
E00-E89: Endocrine, nutritional and metabolic diseases	Metabolic disorders	E70-E89	PPARD;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 1 diabetes	E10	PPARD;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	PPARD; CES1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypercholesterolemia	E78	CES1;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Euphorbia retusa

Taxonomic Information:

Plant External Links:

Used in Medicines:

Geographical Distribution:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities