CMAUP Plant Collective Molecular Activities

Plant Name: Pisonia aculeata

Taxonomic Information:

Plant ID: NPO25983
Plant Latin Name: Pisonia aculeata
Taxonomy Genus: Pisonia
Taxonomy Family: Nyctaginaceae

Plant External Links:

NCBI TaxonomyDB: 363212
Plant-of-the-World-Online: 326897-2

Used in Medicines:

Country/Region:

India; Mexico

Traditional Medicine System:

Indian Folk; Siddha

Geographical Distribution:

Brazil; Madagascar; Bangladesh; Sudan; Costa Rica; Cambodia; Bahamas; Ethiopia; Trinidad and Tobago; Peru; Nigeria; Bolivia; Venezuela; Cote d'Ivoire; Benin; Ghana; Australia; Cuba; El Salvador; Cape Verde; United States; Guatemala; China; Haiti; Belize; Tanzania; Uganda; Philippines; Indonesia; New Caledonia; Mauritius; Sri Lanka; Dominican Republic; Jamaica; Honduras; Myanmar; Mexico; Nicaragua; South Africa; India; Mozambique; Colombia; Paraguay; Kenya; Fiji

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1;
Unclassified	NPC1; RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0071404; cellular response to low-density lipoprotein particle stimulus	2.173E-03	1.000E+00	NPC1
BP	Unclassified;	GO:2000188; regulation of cholesterol homeostasis	2.173E-03	1.000E+00	NPC1
BP	GO:0051179; localization	GO:0033344; cholesterol efflux	3.723E-03	1.000E+00	NPC1
BP	GO:0007610; behavior	GO:0007628; adult walking behavior	4.188E-03	1.000E+00	NPC1
BP	GO:0050896; response to stimulus	GO:0046686; response to cadmium ion	8.673E-03	1.000E+00	NPC1
BP	GO:0065007; biological regulation	GO:0042632; cholesterol homeostasis	1.022E-02	1.000E+00	NPC1
BP	GO:0009987; cellular process	GO:0071383; cellular response to steroid hormone stimulus	1.145E-02	1.000E+00	NPC1
BP	GO:0009987; cellular process	GO:0006302; double-strand break repair	2.633E-02	1.000E+00	TDP1
BP	GO:0008152; metabolic process	GO:0006486; protein glycosylation	4.271E-02	1.000E+00	NPC1
CC	GO:0044464; cell part	GO:0005764; lysosome	5.958E-04	1.000E+00	NPC1, RAB9A
CC	GO:0043226; organelle	GO:0042470; melanosome	1.561E-02	1.000E+00	RAB9A
CC	GO:0044464; cell part	GO:0005635; nuclear envelope	2.510E-02	1.000E+00	NPC1
CC	GO:0016020; membrane	GO:0045121; membrane raft	4.482E-02	1.000E+00	NPC1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	2.026E-02	2.026E-02	RAB9A
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	1.834E-02	2.026E-02	NPC1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases