CMAUP Plant Collective Molecular Activities

Plant Name: Rhamnus cathartica

Taxonomic Information:

Plant ID: NPO25962
Plant Latin Name: Rhamnus cathartica
Taxonomy Genus: Rhamnus
Taxonomy Family: Rhamnaceae

Plant External Links:

NCBI TaxonomyDB: 3610
Plant-of-the-World-Online: 718256-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Medicinal Functions:

Cathartic; Depurative; Diuretic; Laxative; Purgative

Geographical Distribution:

Italy; France; Ireland; Norway; Belarus; Algeria; China; Belgium; Germany; Spain; Ukraine; Netherlands; Denmark; Poland; Finland; United States; Morocco; Sweden; Switzerland; Russia; Bulgaria; Romania; Albania; Portugal; United Kingdom; Austria; Greece; Hungary

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN2;
Lyase	CA1; CA7; CA12; CA9; CA13;
Enzyme_unclassified	HSD17B10;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	3.525E-13	3.838E-09	CA1, CA12, CA13, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.015E-12	7.366E-09	CA1, CA12, CA13, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	2.554E-06	6.178E-03	CA1, CA12, CA13, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.813E-15	6.126E-11	CA1, CA12, CA13, CA7, CA9

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	4.871E-15	2.435E-14	CA12, CA1, CA7, CA9, CA13
09100 Metabolism	09105 Amino acid metabolism	hsa00280	Valine, leucine and isoleucine degradation	1.668E-02	4.171E-02	HSD17B10
09130 Environmental Information Processing	09132 Signal transduction	hsa04630	Jak-STAT signaling pathway	5.401E-02	7.168E-02	PTPN2
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	5.735E-02	7.168E-02	HSD17B10
Unclassified	Unclassified	hsa01100	Metabolic pathways	3.609E-01	3.609E-01	HSD17B10

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases