CMAUP Plant Collective Molecular Activities

Plant Name: Helleborus niger

Taxonomic Information:

Plant ID: NPO25809
Plant Latin Name: Helleborus niger
Taxonomy Genus: Helleborus
Taxonomy Family: Ranunculaceae

Plant External Links:

NCBI TaxonomyDB: 171896
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Italy; Germany; India; China

Traditional Medicine System:

Indian Folk; Unani; Siddha; Ayurveda; TCM; Homeopathy

Medicinal Functions:

Anthelmintic; Antiemetic; Cardiac; Cathartic; Diuretic; Emetic; Emmenagogue; Homeopathy; Irritant; Miscellany; Narcotic; Parasiticide; Purgative

Geographical Distribution:

Germany; Italy; China; India

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPR35;
Protein Phosphatase	PTPN1;
SLC superfamily of solute carriers	SLCO1B3; SLCO1B1;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
SLC superfamily of solute carriers	SLCO1B3	Solute carrier organic anion transporter family member 1B3	Q9NPD5	CHEMBL1743121
SLC superfamily of solute carriers	SLCO1B1	Solute carrier organic anion transporter family member 1B1	Q9Y6L6	CHEMBL1697668
Small molecule receptor (family A GPCR)	GPR35	G-protein coupled receptor 35	Q9HC97	CHEMBL1293267

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0043252; sodium-independent organic anion transport	1.214E-05	7.602E-02	SLCO1B1, SLCO1B3
BP	GO:0051179; localization	GO:0015721; bile acid and bile salt transport	1.396E-05	7.602E-02	SLCO1B1, SLCO1B3
MF	GO:0005215; transporter activity	GO:0015125; bile acid transmembrane transporter activity	4.916E-06	7.602E-02	SLCO1B1, SLCO1B3
MF	GO:0005215; transporter activity	GO:0015347; sodium-independent organic anion transmembrane transporter activity	8.864E-06	7.602E-02	SLCO1B1, SLCO1B3
CC	GO:0016020; membrane	GO:0016323; basolateral plasma membrane	5.464E-04	8.498E-01	SLCO1B1, SLCO1B3
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	8.281E-04	9.491E-01	PTPN1
CC	GO:0044464; cell part	GO:0097443; sorting endosome	1.242E-03	9.659E-01	PTPN1
CC	GO:0044425; membrane part	GO:0005887; integral component of plasma membrane	1.465E-03	1.000E+00	GPR35, SLCO1B1, SLCO1B3

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	7.421E-05	3.711E-04	SLCO1B1, SLCO1B3
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	1.472E-02	3.439E-02	PTPN1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.162E-02	3.439E-02	PTPN1
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	2.751E-02	3.439E-02	PTPN1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	5.426E-02	5.426E-02	GPR35

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	PTPN1;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	PTPN1;
A00-B99: Certain infectious and parasitic diseases	Infections	A00-B99	PTPN1;
E00-E89: Endocrine, nutritional and metabolic diseases	Obesity	E66	PTPN1;
NA: NA	Colour dead tissues	NA	PTPN1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases