Plant Name: Harungana madagascariensis
Taxonomic Information:
Plant ID: NPO25801
Plant Latin Name: Harungana madagascariensis
Taxonomy Genus: Harungana
Taxonomy Family: Hypericaceae
Plant External Links:
NCBI TaxonomyDB:
198768
Plant-of-the-World-Online:
153822-3
Used in Medicines:
Country/Region:
Kenya; Tanzania; Rwanda; China; GuineaTraditional Medicine System:
TCMGeographical Distribution:
Madagascar; Sudan; Guinea; Rwanda; Nigeria; Cameroon; Cote d'Ivoire; Benin; Ghana; Zambia; Malawi; Togo; Zimbabwe; China; Sierra Leone; Liberia; Gambia; Tanzania; Mauritius; Gabon; Guinea-Bissau; Mali; Angola; Chad; Equatorial Guinea; Burkina Faso; Senegal; Congo; Mozambique; Uganda; Burundi; Kenya
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ALPL; HSD17B10; | |
| GAA; | |
| CA2; CA5B; CA6; CA12; CA1; CA5A; | |
| ELANE; | |
| NFKB1; | |
| MAPT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | ALPL | Alkaline phosphatase, tissue-nonspecific isozyme | P05186 | CHEMBL5979 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA5B | Carbonic anhydrase VB | Q9Y2D0 | CHEMBL3969 |
| Lyase | CA6 | Carbonic anhydrase VI | P23280 | CHEMBL3025 |
| Lyase | CA12 | Carbonic anhydrase XII | O43570 | CHEMBL3242 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Lyase | CA5A | Carbonic anhydrase VA | P35218 | CHEMBL4789 |
| Serine protease | ELANE | Leukocyte elastase | P08246 | CHEMBL248 |
| Transcription Factor | NFKB1 | Nuclear factor NF-kappa-B p105 subunit | P19838 | CHEMBL3251 |
| Unclassified | MAPT | Microtubule-associated protein tau | P10636 | CHEMBL1293224 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0006730; one-carbon metabolic process | 2.477E-14 | 2.697E-10 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 8.957E-14 | 6.502E-10 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| MF | GO:0005488; binding | GO:0008270; zinc ion binding | 4.056E-06 | 8.833E-03 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 6.400E-17 | 1.394E-12 | CA1, CA12, CA2, CA5A, CA5B, CA6 |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 5.300E-06 | 1.049E-02 | CA1, CA2 |
| BP | GO:0051179; localization | GO:0006810; transport | 7.561E-06 | 1.372E-02 | CA1, CA12, CA2, CA5A, CA5B, CA6, ELANE, GAA, MAPT, NFKB1 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 1.284E-16 | 8.473E-15 | CA12, CA1, CA5B, CA2, CA5A, CA6 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection | 4.006E-02 | 9.832E-02 | NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 3.774E-02 | 9.832E-02 | NFKB1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04662 | B cell receptor signaling pathway | 4.294E-02 | 9.832E-02 | NFKB1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05131 | Shigellosis | 3.832E-02 | 9.832E-02 | NFKB1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04920 | Adipocytokine signaling pathway | 4.121E-02 | 9.832E-02 | NFKB1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04971 | Gastric acid secretion | 4.352E-02 | 9.832E-02 | CA2 |
| 09160 Human Diseases | 09161 Cancers | hsa05220 | Chronic myeloid leukemia | 4.294E-02 | 9.832E-02 | NFKB1 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04668 | TNF signaling pathway | 6.406E-02 | 9.832E-02 | NFKB1 |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 6.349E-02 | 9.832E-02 | NFKB1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| C00-D49: Neoplasms | Colon cancer | C50 | ALPL; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | NFKB1; |
| A00-B99: Certain infectious and parasitic diseases | Anthelmintic | B89 | ALPL; |
| C00-D49: Neoplasms | Cancer | C00-C96 | NFKB1; |
| Q00-Q99: Congenital malformations, deformations and chromosomal abnormalities | Genetic disease | Q00-Q99 | ALPL; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
