Plant Name: Piper divaricatum
Taxonomic Information:
Plant ID: NPO25797
Plant Latin Name: Piper divaricatum
Taxonomy Genus: Piper
Taxonomy Family: Piperaceae
Plant External Links:
NCBI TaxonomyDB:
405324
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| TDP1; RECQL; HPGD; ALDH1A1; | |
| GAA; | |
| THRB; | |
| RAB9A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Enzyme_unclassified | RECQL | ATP-dependent DNA helicase Q1 | P46063 | CHEMBL1293236 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Hydrolase | GAA | Lysosomal alpha-glucosidase | P10253 | CHEMBL2608 |
| Nuclear hormone receptor subfamily 1 group A | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0000023; maltose metabolic process | 1.087E-03 | 1.000E+00 | GAA |
| BP | GO:0008152; metabolic process | GO:2001300; lipoxin metabolic process | 2.173E-03 | 1.000E+00 | HPGD |
| BP | GO:0009987; cellular process | GO:0000733; DNA strand renaturation | 3.257E-03 | 1.000E+00 | RECQL |
| BP | GO:0032501; multicellular organismal process | GO:0050884; neuromuscular process controlling posture | 3.980E-03 | 1.000E+00 | GAA |
| BP | GO:0008152; metabolic process | GO:0006069; ethanol oxidation | 4.341E-03 | 1.000E+00 | ALDH1A1 |
| BP | GO:0008152; metabolic process | GO:0019372; lipoxygenase pathway | 5.785E-03 | 1.000E+00 | HPGD |
| BP | GO:0009987; cellular process | GO:0046716; muscle cell cellular homeostasis | 6.506E-03 | 1.000E+00 | GAA |
| BP | GO:0022414; reproductive process | GO:0030728; ovulation | 6.506E-03 | 1.000E+00 | HPGD |
| BP | GO:0008283; cell proliferation | GO:1904707; positive regulation of vascular smooth muscle cell proliferation | 7.947E-03 | 1.000E+00 | HPGD |
| BP | GO:0008152; metabolic process | GO:0006693; prostaglandin metabolic process | 9.386E-03 | 1.000E+00 | HPGD |
| BP | GO:0008152; metabolic process | GO:0042572; retinol metabolic process | 1.082E-02 | 1.000E+00 | ALDH1A1 |
| BP | GO:0032501; multicellular organismal process | GO:0003007; heart morphogenesis | 1.154E-02 | 1.000E+00 | GAA |
| BP | GO:0008152; metabolic process | GO:0006006; glucose metabolic process | 3.989E-02 | 1.000E+00 | GAA |
| BP | GO:0050896; response to stimulus | GO:0045471; response to ethanol | 4.129E-02 | 1.000E+00 | HPGD |
| BP | GO:0050896; response to stimulus | GO:0032355; response to estradiol | 4.409E-02 | 1.000E+00 | HPGD |
| BP | GO:0009987; cellular process | GO:0043401; steroid hormone mediated signaling pathway | 4.618E-02 | 1.000E+00 | THRB |
| CC | GO:0044421; extracellular region part | GO:0070062; extracellular exosome | 1.054E-03 | 1.000E+00 | ALDH1A1, GAA, HPGD, RAB9A, THRB |
| CC | GO:0043226; organelle | GO:0042470; melanosome | 3.604E-02 | 1.000E+00 | RAB9A |
| CC | GO:0044464; cell part | GO:0005770; late endosome | 4.792E-02 | 1.000E+00 | RAB9A |
| MF | GO:0003824; catalytic activity | GO:0004574; oligo-1,6-glucosidase activity | 7.247E-04 | 1.000E+00 | GAA |
| MF | GO:0003824; catalytic activity | GO:0032450; maltose alpha-glucosidase activity | 1.087E-03 | 1.000E+00 | GAA |
| MF | GO:0005488; binding | GO:0005497; androgen binding | 1.449E-03 | 1.000E+00 | ALDH1A1 |
| MF | GO:0003824; catalytic activity | GO:0004558; alpha-1,4-glucosidase activity | 1.449E-03 | 1.000E+00 | GAA |
| MF | GO:0003824; catalytic activity | GO:0009378; four-way junction helicase activity | 1.811E-03 | 1.000E+00 | RECQL |
| MF | GO:0003824; catalytic activity | GO:0043140; ATP-dependent 3'-5' DNA helicase activity | 2.534E-03 | 1.000E+00 | RECQL |
| MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 2.534E-03 | 1.000E+00 | ALDH1A1 |
| MF | GO:0005488; binding | GO:0070324; thyroid hormone binding | 2.534E-03 | 1.000E+00 | THRB |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 2.534E-03 | 1.000E+00 | THRB |
| MF | GO:0005488; binding | GO:0036310; annealing helicase activity | 2.896E-03 | 1.000E+00 | RECQL |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 2.119E-02 | 1.000E+00 | THRB |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00500 | Starch and sucrose metabolism | 1.944E-02 | 6.760E-02 | GAA |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.045E-02 | 6.760E-02 | GAA |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.253E-02 | 6.760E-02 | ALDH1A1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 4.058E-02 | 6.997E-02 | THRB |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05162 | Measles | 4.665E-02 | 6.997E-02 | RAB9A |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 4.227E-02 | 6.997E-02 | GAA |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 6.539E-02 | 7.357E-02 | GAA, ALDH1A1 |
| 09160 Human Diseases | 09161 Cancers | hsa05202 | Transcriptional misregulation in cancer | 6.133E-02 | 7.357E-02 | HPGD |
| 09130 Environmental Information Processing | 09133 Signaling molecules and interaction | hsa04080 | Neuroactive ligand-receptor interaction | 9.303E-02 | 9.303E-02 | THRB |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypothyroidism | E03 | THRB; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Wound healing | T14.0-T14.1 | THRB; |
| E00-E89: Endocrine, nutritional and metabolic diseases | High cholesterol levels in blood | E78.0 | THRB; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | THRB; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperthyroidism | E05 | THRB; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Lipid metabolism disorder | E75-E78 | THRB; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
