CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Enzyme_unclassified	TDP1; RECQL; HPGD; ALDH1A1;
Hydrolase	GAA;
Nuclear hormone receptor subfamily 1 group A	THRB;
Unclassified	RAB9A;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	HPGD	15-hydroxyprostaglandin dehydrogenase [NAD+]	P15428	CHEMBL1293255
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Nuclear hormone receptor subfamily 1 group A	THRB	Thyroid hormone receptor beta-1	P10828	CHEMBL1947
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294

Showing 1 to 7 of 7 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:0000023; maltose metabolic process	1.087E-03	1.000E+00	GAA
BP	GO:0008152; metabolic process	GO:2001300; lipoxin metabolic process	2.173E-03	1.000E+00	HPGD
BP	GO:0009987; cellular process	GO:0000733; DNA strand renaturation	3.257E-03	1.000E+00	RECQL
BP	GO:0032501; multicellular organismal process	GO:0050884; neuromuscular process controlling posture	3.980E-03	1.000E+00	GAA
BP	GO:0008152; metabolic process	GO:0006069; ethanol oxidation	4.341E-03	1.000E+00	ALDH1A1
BP	GO:0008152; metabolic process	GO:0019372; lipoxygenase pathway	5.785E-03	1.000E+00	HPGD
BP	GO:0009987; cellular process	GO:0046716; muscle cell cellular homeostasis	6.506E-03	1.000E+00	GAA
BP	GO:0022414; reproductive process	GO:0030728; ovulation	6.506E-03	1.000E+00	HPGD
BP	GO:0008283; cell proliferation	GO:1904707; positive regulation of vascular smooth muscle cell proliferation	7.947E-03	1.000E+00	HPGD
BP	GO:0008152; metabolic process	GO:0006693; prostaglandin metabolic process	9.386E-03	1.000E+00	HPGD

Showing 1 to 10 of 30 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09101 Carbohydrate metabolism	hsa00500	Starch and sucrose metabolism	1.944E-02	6.760E-02	GAA
09100 Metabolism	09101 Carbohydrate metabolism	hsa00052	Galactose metabolism	1.045E-02	6.760E-02	GAA
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.253E-02	6.760E-02	ALDH1A1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	9.303E-02	9.303E-02	THRB
09140 Cellular Processes	09141 Transport and catabolism	hsa04142	Lysosome	4.227E-02	6.997E-02	GAA
09150 Organismal Systems	09152 Endocrine system	hsa04919	Thyroid hormone signaling pathway	4.058E-02	6.997E-02	THRB
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	4.665E-02	6.997E-02	RAB9A
09160 Human Diseases	09161 Cancers	hsa05202	Transcriptional misregulation in cancer	6.133E-02	7.357E-02	HPGD
Unclassified	Unclassified	hsa01100	Metabolic pathways	6.539E-02	7.357E-02	GAA, ALDH1A1

Showing 1 to 9 of 9 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
E00-E89: Endocrine, nutritional and metabolic diseases	Hypothyroidism	E03	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	High cholesterol levels in blood	E78.0	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperthyroidism	E05	THRB;
E00-E89: Endocrine, nutritional and metabolic diseases	Lipid metabolism disorder	E75-E78	THRB;
S00-T88: Injury, poisoning and certain other consequences of external causes	Wound healing	T14.0-T14.1	THRB;

Showing 1 to 6 of 6 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Piper divaricatum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities