Plant Name: Vicia sativa
Taxonomic Information:
Plant ID: NPO25779
Plant Latin Name: Vicia sativa
Taxonomy Genus: Vicia
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
3908
Plant-of-the-World-Online:
525117-1
Used in Medicines:
Country/Region:
Turkey; Pakistan; China; Lebanon; IndiaTraditional Medicine System:
Indian Folk; TCMGeographical Distribution:
Turkey; Afghanistan; Italy; Bangladesh; Lebanon; Nepal; Mongolia; France; Rwanda; Ireland; Argentina; Norway; Ecuador; Turkmenistan; Uzbekistan; Saudi Arabia; Australia; Iran; Algeria; Cuba; Iceland; Venezuela; Russia; China; Chile; Oman; Belgium; Germany; Dominican Republic; Iraq; Kazakhstan; Spain; Ukraine; Netherlands; Libya; Pakistan; Denmark; Poland; Finland; United States; Morocco; Sweden; Belarus; Kenya; Switzerland; Uruguay; New Zealand; Yemen; Haiti; Bulgaria; Jamaica; Romania; Albania; Angola; Portugal; Myanmar; Mexico; Egypt; Tajikistan; South Africa; India; United Kingdom; Tunisia; Austria; Vietnam; Colombia; Greece; Sri Lanka; Hungary; Taiwan; Cyprus
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| CDC25B; | |
| CES1; CES2; | |
| ACHE; | |
| CA2; CA14; CA1; | |
| PPARA; PPARD; | |
| NR1H4; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | CES1 | Acyl coenzyme A:cholesterol acyltransferase | P23141 | CHEMBL2265 |
| Enzyme_unclassified | CES2 | Carboxylesterase 2 | O00748 | CHEMBL3180 |
| Hydrolase | ACHE | Acetylcholinesterase | P22303 | CHEMBL220 |
| Lyase | CA2 | Carbonic anhydrase II | P00918 | CHEMBL205 |
| Lyase | CA14 | Carbonic anhydrase XIV | Q9ULX7 | CHEMBL3510 |
| Lyase | CA1 | Carbonic anhydrase I | P00915 | CHEMBL261 |
| Nuclear hormone receptor subfamily 1 group C | PPARA | Peroxisome proliferator-activated receptor alpha | Q07869 | CHEMBL239 |
| Nuclear hormone receptor subfamily 1 group C | PPARD | Peroxisome proliferator-activated receptor delta | Q03181 | CHEMBL3979 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Protein Phosphatase | CDC25B | Dual specificity phosphatase Cdc25B | P30305 | CHEMBL4804 |
Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0003824; catalytic activity | GO:0004089; carbonate dehydratase activity | 4.532E-08 | 3.289E-04 | CA1, CA14, CA2 |
| MF | GO:0003824; catalytic activity | GO:0047374; methylumbelliferyl-acetate deacetylase activity | 7.235E-07 | 2.626E-03 | CES1, CES2 |
| BP | GO:0051179; localization | GO:0015701; bicarbonate transport | 1.309E-06 | 4.071E-03 | CA1, CA14, CA2 |
| MF | GO:0140110; transcription regulator activity | GO:0004879; nuclear receptor activity | 1.818E-06 | 4.399E-03 | NR1H4, PPARA, PPARD |
| MF | GO:0060089; molecular transducer activity | GO:0003707; steroid hormone receptor activity | 3.199E-06 | 5.805E-03 | NR1H4, PPARA, PPARD |
| MF | GO:0003824; catalytic activity | GO:0004064; arylesterase activity | 3.614E-06 | 6.054E-03 | CA1, CA2 |
Enriched KEGG Pathways of Target Proteins (Activity≤1μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09102 Energy metabolism | hsa00910 | Nitrogen metabolism | 6.098E-08 | 1.464E-06 | CA1, CA2, CA14 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00983 | Drug metabolism - other enzymes | 2.302E-04 | 2.762E-03 | CES2, CES1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa03320 | PPAR signaling pathway | 5.185E-04 | 3.294E-03 | PPARA, PPARD |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 5.490E-04 | 3.294E-03 | CA2, NR1H4 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| G00-G99: Diseases of the nervous system G00-G99 | Neurodegenerative disease | G30-G32 | ACHE; |
| K00-K95: Diseases of the digestive system | Non-alcoholic fatty liver disease | K76.0 | PPARD; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Obesity | E66 | PPARD; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Insomnia | F51.0, G47.0 | CA2; |
| G00-G99: Diseases of the nervous system G00-G99 | Epileptic seizures | G40, P90, R56 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis | G70.0 | ACHE; |
| NA: NA | Edema | NA | CA2; |
| I00-I99: Diseases of the circulatory system | Edema associated with congestive heart failure | I50, R60.9 | CA2; |
| NA: NA | Early satiation associated with functional dyspepsia | NA | ACHE; |
| NA: NA | Dyslipidemia | NA | PPARD; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Dyslipidaemias | E78 | PPARD; |
| K00-K95: Diseases of the digestive system | Duodenal ulcers | K25-K27 | CA2; CA1; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Cognitive disorders | F01-F07, F04, F05, R41.3 | ACHE; |
| I00-I99: Diseases of the circulatory system | High blood pressure | I10-I16 | CA2; |
| G00-G99: Diseases of the nervous system G00-G99 | Central nervous system disease | G00-G99 | PPARD; |
| H00-H59: Diseases of the eye and adnexa | Open-angle glaucoma | H40-H42 | ACHE; CA2; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hypercholesterolemia | E78 | CES1; |
| I00-I99: Diseases of the circulatory system | Atherosclerosis | I70 | PPARD; CES1; |
| I00-I99: Diseases of the circulatory system | Arteriosclerosis | I70 | CES1; |
| C00-D49: Neoplasms | Acute lymphoblastic leukemia | C91.0 | CES1; |
| H00-H59: Diseases of the eye and adnexa | Chronic glaucoma | H40-H42 | ACHE; CA1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Hyperlipidaemia | E78 | PPARD; CES1; |
| C00-D49: Neoplasms | Cancer | C00-C96 | ACHE; CDC25B; CA1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 2 diabetes | E11 | PPARD; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Type 1 diabetes | E10 | PPARD; |
| G00-G99: Diseases of the nervous system G00-G99 | Alzheimer disease | G30 | ACHE; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Anxiety disorder | F32, F40-F42 | ACHE; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poison intoxication | T36-T50 | ACHE; |
| S00-T88: Injury, poisoning and certain other consequences of external causes | Poisoning due to pesticides and chemicals | T36-T50 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Pediculus humanus capitis | B85.0 | ACHE; |
| K00-K95: Diseases of the digestive system | Xerostomia | K11.7, R68.2 | ACHE; |
| I00-I99: Diseases of the circulatory system | Peripheral vascular disease | I73.9 | CES1; |
| NA: NA | Upper abdominal bloating | NA | ACHE; |
| N00-N99: Diseases of the genitourinary system | Urinary dysfunction | N39.3-N39.4 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Pain | G64, G90.0, R52, G89 | ACHE; |
| G00-G99: Diseases of the nervous system G00-G99 | Parkinson's disease | G20 | ACHE; |
| A00-B99: Certain infectious and parasitic diseases | Helminth infection | A00-B99 | ACHE; |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | ACHE; CA1; |
| G00-G99: Diseases of the nervous system G00-G99 | Myasthenia gravis diagnosis | G70.0 | ACHE; |
| F01-F99: Mental, Behavioral and Neurodevelopmental disorders | Mild cognitive impairment | F06.7 | ACHE; |
>> Profiles of ingredients and activity landscape
>> Collective molecular activities profile at 10μM cutoff
>> Targets derived from weak experimental activities
