Plant Name: Senecio ruwenzoriensis
Taxonomic Information:
Plant ID: NPO25768
Plant Latin Name: Senecio ruwenzoriensis
Taxonomy Genus: Senecio
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
1896791
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| PTPN2; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Protein Phosphatase | PTPN2 | T-cell protein-tyrosine phosphatase | P17706 | CHEMBL3807 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| MF | GO:0005488; binding | GO:0097677; STAT family protein binding | 3.106E-04 | 3.560E-01 | PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0004726; non-membrane spanning protein tyrosine phosphatase activity | 4.142E-04 | 3.921E-01 | PTPN2 |
| MF | GO:0005488; binding | GO:0030971; receptor tyrosine kinase binding | 2.899E-03 | 9.018E-01 | PTPN2 |
| CC | GO:0044464; cell part | GO:0005783; endoplasmic reticulum | 4.887E-02 | 1.000E+00 | PTPN2 |
| MF | GO:0003824; catalytic activity | GO:0016791; phosphatase activity | 1.408E-02 | 1.000E+00 | PTPN2 |
| MF | GO:0005488; binding | GO:0019901; protein kinase binding | 2.992E-02 | 1.000E+00 | PTPN2 |
| MF | Unclassified; | GO:0032403; protein complex binding | 4.116E-02 | 1.000E+00 | PTPN2 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04630 | Jak-STAT signaling pathway | 7.900E-03 | 7.900E-03 | PTPN2 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
