CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1;
Peptide receptor (family A GPCR)	TSHR;
Protein Phosphatase	PTPN1; PTPN2; ACP1; PTPRF; CDC25B;
Enzyme_unclassified	RECQL; PLA2G1B; HSD11B1; AKR1B10; POLB;
Lyase	CA2; CA12; CA1; CA9; CA14; CA7;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	7.112E-12	5.162E-08	CA1, CA12, CA14, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	4.333E-10	1.348E-06	CA1, CA12, CA2, CA7, CA9
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	7.849E-08	1.676E-04	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.712E-06	3.368E-03	CA2, CA7
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	3.712E-06	3.368E-03	GPBAR1, NR1H4
BP	GO:0009987; cellular process	GO:1902202; regulation of hepatocyte growth factor receptor signaling pathway	7.420E-06	5.984E-03	PTPN1, PTPN2
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	8.028E-06	6.243E-03	NR1H4, PPARA, PPARD, PTPN2
BP	GO:0009987; cellular process	GO:0043401; steroid hormone mediated signaling pathway	1.304E-05	9.467E-03	NR1H4, PPARA, PPARD, RORC
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	5.148E-15	1.121E-10	CA1, CA12, CA14, CA2, CA7, CA9
MF	GO:0005488; binding	GO:0008270; zinc ion binding	6.741E-09	1.631E-05	CA1, CA12, CA2, CA7, CA9, NR1H4, PPARA, PPARD, PTPN1, RORC

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.032E-14	5.056E-13	CA12, CA1, CA2, CA7, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.144E-02	1.093E-01	PLA2G1B
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	1.997E-02	1.093E-01	PPARA, TSHR
09140 Cellular Processes	09144 Cellular community - eukaryotes	hsa04520	Adherens junction	7.119E-05	1.744E-03	PTPN1, ACP1, PTPRF
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.592E-03	2.687E-02	PPARA, PPARD
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	2.741E-03	2.687E-02	CA2, NR1H4
09150 Organismal Systems	09154 Digestive system	hsa04972	Pancreatic secretion	4.948E-03	4.041E-02	CA2, PLA2G1B
09150 Organismal Systems	09152 Endocrine system	hsa04910	Insulin signaling pathway	1.011E-02	7.080E-02	PTPN1, PTPRF
09150 Organismal Systems	09159 Environmental adaptation	hsa04710	Circadian rhythm	3.250E-02	1.093E-01	RORC
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	2.249E-04	3.673E-03	PTPN1, PPARA, PTPRF

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Cancer	C00-C96	CDC25B;

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Tanacetum praeteritum

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities