CMAUP Plant Collective Molecular Activities

Plant Name: Acorus calamus

Taxonomic Information:

Plant ID: NPO25682
Plant Latin Name: Acorus calamus
Taxonomy Genus: Acorus
Taxonomy Family: Acoraceae

Plant External Links:

NCBI TaxonomyDB: 4465
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

Turkey; Finland; Italy; South Africa; India; Indonesia; Lithuania; China; Greece; Thailand; Bulgaria

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM

Medicinal Functions:

Abortifacient; Anodyne; Antirheumatic; Aphrodisiac; Aromatic; Carminative; Diaphoretic; Emmenagogue; Febrifuge; Hallucinogenic; Homeopathy; Odontalgic; Sedative; Stimulant; Stomachic; Tonic; Vermifuge

Geographical Distribution:

Turkey; Indonesia; Italy; South Africa; Lithuania; Finland; India; China; Greece; Thailand; Bulgaria

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Protein Kinase	MAPK1;
Lyase	CA2; CA3; CA14; CA5A; CA6; CA12; CA9; CA1; CA7;
Oxidoreductase	HMGCR;
Metallo protease	MMP12; MMP2;
Transcription Factor	TP53;
Unclassified	MAPT; LMNA;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205
Lyase	CA3	Carbonic anhydrase III	P07451	CHEMBL2885
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Metallo protease	MMP12	Matrix metalloproteinase 12	P39900	CHEMBL4393
Metallo protease	MMP2	Matrix metalloproteinase-2	P08253	CHEMBL333
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Oxidoreductase	HMGCR	HMG-CoA reductase	P04035	CHEMBL402
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0008270; zinc ion binding	1.647E-10	4.482E-07	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, MMP12, MMP2, TP53
BP	GO:0065007; biological regulation	GO:0030641; regulation of cellular pH	3.082E-06	4.194E-03	CA2, CA7, MAPK1, TP53
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	3.375E-06	4.313E-03	CA2, CA7
MF	GO:0005488; binding	GO:0051721; protein phosphatase 2A binding	3.565E-06	4.313E-03	HMGCR, MAPT, TP53
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.746E-06	6.120E-03	CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.424E-24	3.101E-20	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.985E-19	2.161E-15	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.262E-17	6.868E-14	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.684E-05	1.265E-02	CYP1A2, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	1.684E-05	1.265E-02	CA1, CA2
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	7.381E-05	4.121E-02	SMN1, SMN2
CC	GO:0032991; macromolecular complex	GO:0032797; SMN complex	8.718E-05	4.630E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	5.052E-24	6.365E-22	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14
09160 Human Diseases	09161 Cancers	hsa05219	Bladder cancer	1.037E-05	6.530E-04	MMP2, MAPK1, TP53
09150 Organismal Systems	09154 Digestive system	hsa04976	Bile secretion	5.446E-05	2.287E-03	CA2, HMGCR, CYP3A4
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	4.071E-04	8.801E-03	LMNA, MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05216	Thyroid cancer	4.191E-04	8.801E-03	MAPK1, TP53
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	4.191E-04	8.801E-03	CYP1A2, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	2.228E-03	1.662E-02	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05218	Melanoma	2.498E-03	1.662E-02	MAPK1, TP53
09160 Human Diseases	09161 Cancers	hsa05220	Chronic myeloid leukemia	2.638E-03	1.662E-02	MAPK1, TP53
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.638E-03	1.662E-02	CYP1A2, CYP3A4

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1; TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1; TP53;
G00-G99: Diseases of the nervous system G00-G99	Spinal muscular atrophy	G00-G99	SMN1;SMN2;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases