ALOX15; | |
KDM4E; | |
L3MBTL1; |
Cytochrome P450 Enzymes: |
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Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
---|---|---|---|---|
Enzyme_unclassified | ALOX15 | Arachidonate 15-lipoxygenase | P16050 | CHEMBL2903 |
Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
Methyl-lysine/arginine binding protein | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1 | Q9Y468 | CHEMBL1287622 |
GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|
BP | GO:0008152; metabolic process | GO:2001303; lipoxin A4 biosynthetic process | 3.106E-04 | 7.246E-01 | ALOX15 |
MF | GO:0003824; catalytic activity | GO:0051213; dioxygenase activity | 6.421E-05 | 7.246E-01 | ALOX15, KDM4E |
MF | GO:0003824; catalytic activity | GO:0047977; hepoxilin-epoxide hydrolase activity | 3.106E-04 | 7.246E-01 | ALOX15 |
MF | GO:0003824; catalytic activity | GO:0050473; arachidonate 15-lipoxygenase activity | 4.659E-04 | 7.246E-01 | ALOX15 |
MF | GO:0003824; catalytic activity | GO:0004052; arachidonate 12-lipoxygenase activity | 4.659E-04 | 7.246E-01 | ALOX15 |
MF | GO:0003824; catalytic activity | GO:0051120; hepoxilin A3 synthase activity | 4.659E-04 | 7.246E-01 | ALOX15 |
BP | GO:0050896; response to stimulus | GO:0009611; response to wounding | 2.755E-02 | 1.000E+00 | ALOX15 |
BP | GO:0022610; biological adhesion | GO:0010810; regulation of cell-substrate adhesion | 2.892E-02 | 1.000E+00 | ALOX15 |
CC | GO:0044464; cell part | GO:0031234; extrinsic component of cytoplasmic side of plasma membrane | 1.114E-02 | 1.000E+00 | ALOX15 |
MF | GO:0005488; binding | GO:0005506; iron ion binding | 2.465E-02 | 1.000E+00 | ALOX15 |
Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
---|---|---|---|---|---|---|
09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 4.344E-03 | 1.738E-02 | ALOX15 |
09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 9.272E-03 | 1.854E-02 | ALOX15 |
09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 1.671E-02 | 2.228E-02 | ALOX15 |
Unclassified | Unclassified | hsa01100 | Metabolic pathways | 1.746E-01 | 1.746E-01 | ALOX15 |
ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
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