Plant Name: Euphorbia latazi
Taxonomic Information:
Plant ID: NPO25626
Plant Latin Name: Euphorbia latazi
Taxonomy Genus: Euphorbia
Taxonomy Family: Euphorbiaceae
Plant External Links:
NCBI TaxonomyDB:
n.a.
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| ADORA3; | |
| NR1H4; | |
| KDM4E; | |
| AKR1B1; POLB; | |
| HTT; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Enzyme_unclassified | POLB | DNA polymerase beta | P06746 | CHEMBL2392 |
| Lysine demethylase | KDM4E | Lysine-specific demethylase 4D-like | B2RXH2 | CHEMBL1293226 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Small molecule receptor (family A GPCR) | ADORA3 | Adenosine A3 receptor | P0DMS8 | CHEMBL256 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0050896; response to stimulus | GO:0006954; inflammatory response | 2.157E-04 | 2.818E-01 | ADORA3, NR1H4, POLB |
| MF | GO:0060089; molecular transducer activity | GO:0038181; bile acid receptor activity | 9.316E-04 | 4.508E-01 | NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0004887; thyroid hormone receptor activity | 2.173E-03 | 6.571E-01 | NR1H4 |
| MF | GO:0060089; molecular transducer activity | GO:0001609; G-protein coupled adenosine receptor activity | 2.173E-03 | 6.571E-01 | ADORA3 |
| MF | GO:0005488; binding | GO:0034452; dynactin binding | 3.412E-03 | 8.077E-01 | HTT |
| CC | GO:0044464; cell part | GO:0005773; vacuole | 4.447E-03 | 8.781E-01 | AKR1B1, HTT |
| CC | GO:0043226; organelle | GO:0005654; nucleoplasm | 6.849E-03 | 9.812E-01 | AKR1B1, HTT, NR1H4, POLB |
| CC | GO:0044464; cell part | GO:0032838; plasma membrane bounded cell projection cytoplasm | 2.063E-02 | 1.000E+00 | AKR1B1 |
| CC | GO:0044464; cell part | GO:0005770; late endosome | 4.121E-02 | 1.000E+00 | HTT |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 1.075E-02 | 3.495E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 8.967E-03 | 3.495E-02 | AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 9.563E-03 | 3.495E-02 | AKR1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 1.757E-02 | 4.569E-02 | AKR1B1 |
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03410 | Base excision repair | 9.860E-03 | 3.495E-02 | POLB |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.111E-02 | 4.575E-02 | NR1H4 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04071 | Sphingolipid signaling pathway | 3.547E-02 | 6.587E-02 | ADORA3 |
| 09130 Environmental Information Processing | 09132 Signal transduction | hsa04022 | cGMP-PKG signaling pathway | 4.907E-02 | 7.794E-02 | ADORA3 |
| 09160 Human Diseases | 09161 Cancers | hsa05203 | Viral carcinogenesis | 5.995E-02 | 7.794E-02 | POLB |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05016 | Huntington's disease | 5.653E-02 | 7.794E-02 | HTT |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
