CMAUP Plant Collective Molecular Activities

Plant Name: Hedychium coronarium

Taxonomic Information:

Plant ID: NPO25518
Plant Latin Name: Hedychium coronarium
Taxonomy Genus: Hedychium
Taxonomy Family: Zingiberaceae

Plant External Links:

NCBI TaxonomyDB: 71610
Plant-of-the-World-Online: 796836-1

Used in Medicines:

Country/Region:

Brazil; China; Indonesia; India

Traditional Medicine System:

TCM; Siddha

Medicinal Functions:

Antirheumatic; Aromatic; Carminative; Febrifuge; Stomachic; Tonic

Geographical Distribution:

Brazil; Madagascar; Bangladesh; Nepal; Costa Rica; Suriname; Argentina; Bolivia; Venezuela; Ecuador; Australia; Cuba; Papua New Guinea; United States; Trinidad and Tobago; China; Thailand; Haiti; Belize; Philippines; Indonesia; New Caledonia; Mauritius; Sri Lanka; Vietnam; French Guiana; Guyana; Dominican Republic; Jamaica; Honduras; Myanmar; Mexico; South Africa; India; Colombia; Paraguay; Taiwan; Fiji

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Protein Phosphatase	PTPN2;
Protein Kinase	MAPK1;
Oxidoreductase	MAOB;
Unclassified	MAPT;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Oxidoreductase	MAOB	Monoamine oxidase B	P27338	CHEMBL2039
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:1900034; regulation of cellular response to heat	9.608E-05	3.758E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0032838; plasma membrane bounded cell projection cytoplasm	7.080E-05	3.758E-01	MAPK1, MAPT
MF	GO:0005488; binding	GO:0019902; phosphatase binding	4.251E-04	3.857E-01	MAPK1, MAPT
CC	GO:0044464; cell part	GO:0030424; axon	1.040E-03	4.506E-01	MAPK1, MAPT
MF	GO:0003824; catalytic activity	GO:0008131; primary amine oxidase activity	1.242E-03	4.506E-01	MAOB
MF	GO:0005488; binding	GO:0097677; STAT family protein binding	1.242E-03	4.506E-01	PTPN2
MF	GO:0003824; catalytic activity	GO:0004726; non-membrane spanning protein tyrosine phosphatase activity	1.656E-03	4.506E-01	PTPN2
MF	GO:0005488; binding	GO:0042802; identical protein binding	2.248E-03	4.907E-01	MAOB, MAPK1, MAPT
MF	GO:0005488; binding	GO:0034452; dynactin binding	2.276E-03	4.907E-01	MAPT
MF	Unclassified;	GO:0004707; MAP kinase activity	2.896E-03	5.532E-01	MAPK1
CC	GO:0044464; cell part	GO:0030673; axolemma	3.309E-03	5.600E-01	MAPT
MF	Unclassified;	GO:0004708; MAP kinase kinase activity	3.103E-03	5.600E-01	MAPK1
MF	GO:0003824; catalytic activity	GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity	3.309E-03	5.600E-01	MAPK1
CC	Unclassified;	GO:0031143; pseudopodium	3.516E-03	5.671E-01	MAPK1

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	1.851E-04	1.543E-02	MAOB, MAPK1
09160 Human Diseases	09164 Substance dependence	hsa05034	Alcoholism	4.723E-04	1.543E-02	MAOB, MAPK1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	4.162E-04	1.543E-02	MAPK1, MAPT
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	9.553E-04	2.340E-02	MAPK1, MAPT
09150 Organismal Systems	09152 Endocrine system	hsa04916	Melanogenesis	1.985E-02	3.462E-02	MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05132	Salmonella infection	1.709E-02	3.462E-02	MAPK1
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	1.492E-02	3.462E-02	MAPK1
09160 Human Diseases	09161 Cancers	hsa05231	Choline metabolism in cancer	2.005E-02	3.462E-02	MAPK1
09150 Organismal Systems	09156 Nervous system	hsa04723	Retrograde endocannabinoid signaling	2.005E-02	3.462E-02	MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04066	HIF-1 signaling pathway	2.044E-02	3.462E-02	MAPK1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases