CMAUP Plant Collective Molecular Activities

Plant Name: Viola philippica

Taxonomic Information:

Plant ID: NPO25302
Plant Latin Name: Viola philippica
Taxonomy Genus: Viola
Taxonomy Family: Violaceae

Plant External Links:

NCBI TaxonomyDB: 316493
Plant-of-the-World-Online: n.a.

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	NPSR1;
Lyase	CA13; CA7; CA12; CA9;
Enzyme_unclassified	GFER; HSD17B10; ALDH1A1; ALOX15;
Cysteine protease	CASP7; CASP1;
Transcription Factor	HIF1A; NFKB1;
ATP-binding cassette	ABCC1;
Unclassified	MAPT;
Oxidoreductase	XDH;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1B1; CYP3A4; CYP1A1; CYP2D6; CYP1A2;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Oxidoreductase	XDH	Xanthine dehydrogenase	P47989	CHEMBL1929
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.019E-11	3.287E-07	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
MF	GO:0005488; binding	GO:0005506; iron ion binding	2.474E-10	1.347E-06	ALOX15, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4, XDH
MF	GO:0005488; binding	GO:0019825; oxygen binding	1.080E-09	3.382E-06	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	1.398E-09	3.382E-06	CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.210E-08	3.008E-05	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.944E-08	6.472E-05	CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	1.322E-07	1.186E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.362E-07	1.186E-04	CA12, CA13, CA7, CA9
MF	GO:0005488; binding	GO:0020037; heme binding	2.208E-07	1.849E-04	CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	2.421E-07	1.941E-04	CYP1A2, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0017144; drug metabolic process	9.135E-07	5.850E-04	ABCC1, ALDH1A1, CYP1A1, CYP1A2, CYP1B1, CYP2D6, CYP3A4
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	1.454E-06	8.798E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0065007; biological regulation	GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process	1.709E-06	1.006E-03	CASP1, CASP7, MAPT, XDH
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	1.934E-06	1.080E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009822; alkaloid catabolic process	3.375E-06	1.709E-03	CYP2D6, CYP3A4
MF	GO:0003824; catalytic activity	GO:0070576; vitamin D 24-hydroxylase activity	3.375E-06	1.709E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	6.746E-06	2.825E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	6.746E-06	2.825E-03	CYP1A2, CYP3A4
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	7.616E-06	3.129E-03	CA9, CASP1, CASP7, CYP1A1, CYP1A2, CYP1B1, NFKB1
MF	GO:0003824; catalytic activity	GO:0101020; estrogen 16-alpha-hydroxylase activity	1.124E-05	4.292E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0002933; lipid hydroxylation	1.684E-05	6.112E-03	CYP1A1, CYP3A4
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	2.356E-05	7.894E-03	CYP1A1, CYP2D6
BP	GO:0008152; metabolic process	GO:2000377; regulation of reactive oxygen species metabolic process	3.013E-05	9.941E-03	CYP1B1, HIF1A, MAPT, XDH

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	1.096E-08	4.383E-07	CYP2D6, CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.118E-09	1.695E-07	CA12, CA7, CA9, CA13
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.673E-07	9.793E-06	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	5.833E-07	1.167E-05	CYP1A2, ALDH1A1, CYP1A1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	1.489E-06	2.383E-05	CYP1A2, CYP1A1, CYP1B1, CYP3A4
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	9.614E-06	1.048E-04	CYP1A2, CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	3.582E-06	4.776E-05	CYP1A2, ALOX15, CYP3A4
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	2.527E-05	2.246E-04	CASP7, CASP1, NFKB1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	4.999E-05	3.999E-04	CYP2D6, CYP1A2, CYP3A4
Unclassified	Unclassified	hsa01100	Metabolic pathways	1.853E-04	1.235E-03	CYP1A2, ALOX15, ALDH1A1, CYP1A1, CYP3A4, HSD17B10, XDH
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	6.417E-05	4.667E-04	CASP7, CASP1, NFKB1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	6.928E-04	4.263E-03	CASP7, MAPT, HSD17B10
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	1.248E-03	6.655E-03	CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00983	Drug metabolism - other enzymes	1.057E-03	6.040E-03	CYP3A4, XDH
09150 Organismal Systems	09151 Immune system	hsa04621	NOD-like receptor signaling pathway	1.619E-03	8.093E-03	CASP1, NFKB1
09150 Organismal Systems	09151 Immune system	hsa04623	Cytosolic DNA-sensing pathway	2.035E-03	9.579E-03	CASP1, NFKB1
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	1.048E-05	1.048E-04	CYP1A2, XDH

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases