Plant Name: Angylocalyx pynaertii
Taxonomic Information:
Plant ID: NPO25301
Plant Latin Name: Angylocalyx pynaertii
Taxonomy Genus: Angylocalyx
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
149630
Plant-of-the-World-Online:
n.a.
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| MAN1B1; FUCA1; PYGL; AGL; | |
| THRB; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | MAN1B1 | Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase | Q9UKM7 | CHEMBL2308 |
| Enzyme_unclassified | FUCA1 | Alpha-L-fucosidase I | P04066 | CHEMBL4176 |
| Enzyme_unclassified | PYGL | Liver glycogen phosphorylase | P06737 | CHEMBL2568 |
| Enzyme_unclassified | AGL | Glycogen debranching enzyme | P35573 | CHEMBL5272 |
| Nuclear hormone receptor subfamily 1 group A | THRB | Thyroid hormone receptor beta-1 | P10828 | CHEMBL1947 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0005975; carbohydrate metabolic process | 1.613E-06 | 1.756E-02 | AGL, FUCA1, MAN1B1, PYGL |
| CC | GO:0044464; cell part | GO:0034774; secretory granule lumen | 4.436E-05 | 9.472E-02 | AGL, FUCA1, PYGL |
| CC | GO:0043226; organelle | GO:1903561; extracellular vesicle | 2.028E-03 | 5.895E-01 | FUCA1, MAN1B1, PYGL, THRB |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00500 | Starch and sucrose metabolism | 7.659E-05 | 8.425E-04 | AGL, PYGL |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 2.158E-03 | 1.187E-02 | AGL, MAN1B1, PYGL |
| 09100 Metabolism | 09107 Glycan biosynthesis and metabolism | hsa00511 | Other glycan degradation | 4.492E-03 | 1.647E-02 | FUCA1 |
| 09100 Metabolism | 09107 Glycan biosynthesis and metabolism | hsa00510 | N-Glycan biosynthesis | 1.219E-02 | 3.353E-02 | MAN1B1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04922 | Glucagon signaling pathway | 2.500E-02 | 4.177E-02 | PYGL |
| 09160 Human Diseases | 09166 Endocrine and metabolic diseases | hsa04931 | Insulin resistance | 2.696E-02 | 4.177E-02 | PYGL |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04919 | Thyroid hormone signaling pathway | 2.916E-02 | 4.177E-02 | THRB |
| 09140 Cellular Processes | 09141 Transport and catabolism | hsa04142 | Lysosome | 3.038E-02 | 4.177E-02 | FUCA1 |
| 09150 Organismal Systems | 09152 Endocrine system | hsa04910 | Insulin signaling pathway | 3.427E-02 | 4.189E-02 | PYGL |
| 09120 Genetic Information Processing | 09123 Folding, sorting and degradation | hsa04141 | Protein processing in endoplasmic reticulum | 4.155E-02 | 4.570E-02 | MAN1B1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
