Plant Name: Sophora secundiflora
Taxonomic Information:
Plant ID: NPO25265
Plant Latin Name: Sophora secundiflora
Taxonomy Genus: Sophora
Taxonomy Family: Fabaceae
Plant External Links:
NCBI TaxonomyDB:
48122
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Unknown.
Geographical Distribution:
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
| NR1H4; | |
| HSD17B10; HPGD; ALDH1A1; | |
| CASP7; CASP1; | |
| NPC1; RAB9A; |
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cysteine protease | CASP7 | Caspase-7 | P55210 | CHEMBL3468 |
| Cysteine protease | CASP1 | Caspase-1 | P29466 | CHEMBL4801 |
| Enzyme_unclassified | HSD17B10 | Endoplasmic reticulum-associated amyloid beta-peptide-binding protein | Q99714 | CHEMBL4159 |
| Enzyme_unclassified | HPGD | 15-hydroxyprostaglandin dehydrogenase [NAD+] | P15428 | CHEMBL1293255 |
| Enzyme_unclassified | ALDH1A1 | Aldehyde dehydrogenase 1A1 | P00352 | CHEMBL3577 |
| Nuclear hormone receptor subfamily 1 group H | NR1H4 | Bile acid receptor FXR | Q96RI1 | CHEMBL2047 |
| Unclassified | NPC1 | Niemann-Pick C1 protein | O15118 | CHEMBL1293277 |
| Unclassified | RAB9A | Ras-related protein Rab-9A | P51151 | CHEMBL1293294 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | Unclassified; | GO:2000188; regulation of cholesterol homeostasis | 1.363E-05 | 1.304E-01 | NPC1, NR1H4 |
| MF | GO:0003824; catalytic activity | GO:0097200; cysteine-type endopeptidase activity involved in execution phase of apoptosis | 1.168E-05 | 1.304E-01 | CASP1, CASP7 |
| BP | GO:0008152; metabolic process | GO:0006629; lipid metabolic process | 4.568E-05 | 2.200E-01 | ALDH1A1, HPGD, HSD17B10, NPC1, NR1H4 |
| BP | GO:0009987; cellular process | GO:0097194; execution phase of apoptosis | 1.047E-04 | 2.200E-01 | CASP1, CASP7 |
| BP | GO:0050896; response to stimulus | GO:0033993; response to lipid | 1.202E-04 | 2.200E-01 | CASP1, HPGD, NPC1, NR1H4 |
| BP | GO:0050896; response to stimulus | GO:0014070; response to organic cyclic compound | 1.234E-04 | 2.200E-01 | CASP1, CASP7, HPGD, NPC1 |
| MF | GO:0005488; binding | GO:0051287; NAD binding | 2.538E-04 | 2.200E-01 | ALDH1A1, HPGD |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 5.306E-03 | 6.583E-01 | NPC1, RAB9A |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09160 Human Diseases | 09167 Infectious diseases | hsa05134 | Legionellosis | 2.057E-04 | 3.446E-03 | CASP7, CASP1 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05133 | Pertussis | 3.829E-04 | 3.446E-03 | CASP7, CASP1 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05010 | Alzheimer's disease | 1.900E-03 | 1.140E-02 | CASP7, HSD17B10 |
| 09100 Metabolism | 09105 Amino acid metabolism | hsa00280 | Valine, leucine and isoleucine degradation | 1.904E-02 | 5.611E-02 | HSD17B10 |
| 09160 Human Diseases | 09163 Neurodegenerative diseases | hsa05014 | Amyotrophic lateral sclerosis (ALS) | 2.022E-02 | 5.611E-02 | CASP1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04621 | NOD-like receptor signaling pathway | 2.258E-02 | 5.611E-02 | CASP1 |
| 09100 Metabolism | 09108 Metabolism of cofactors and vitamins | hsa00830 | Retinol metabolism | 2.571E-02 | 5.611E-02 | ALDH1A1 |
| 09150 Organismal Systems | 09151 Immune system | hsa04623 | Cytosolic DNA-sensing pathway | 2.532E-02 | 5.611E-02 | CASP1 |
| 09150 Organismal Systems | 09154 Digestive system | hsa04976 | Bile secretion | 2.805E-02 | 5.611E-02 | NR1H4 |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05132 | Salmonella infection | 3.389E-02 | 6.101E-02 | CASP1 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
