CMAUP Plant Collective Molecular Activities

Plant Name: Crinum kirkii

Taxonomic Information:

Plant ID: NPO2518
Plant Latin Name: Crinum kirkii
Taxonomy Genus: Crinum
Taxonomy Family: Amaryllidaceae

Plant External Links:

NCBI TaxonomyDB: 209098
Plant-of-the-World-Online: 63940-1

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

Kenya; Tanzania; China; Mozambique

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	GPBAR1; ADRA2C; ADRA2A;
Peptide receptor (family A GPCR)	NMUR2;
Protein Phosphatase	PTPN1; PTPN2; ACP1; CDC25B; PTPRF;
Enzyme_unclassified	RECQL; PLA2G1B; HSD11B1; AKR1B10; AKR1B1; POLB;
Hydrolase	GAA; ATP12A; ACHE;
Protein Kinase	MAPK1;
Lyase	CA13; CA1; CA12; CA9; CA7;
Nuclear hormone receptor subfamily 1 group F	RORC;
Nuclear hormone receptor subfamily 1 group H	NR1H4;
Lysine demethylase	KDM4E;
ATP-binding cassette	ABCC1;
Unclassified	LMNA; RAB9A; NPC1; PAX8;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP1A2; CYP1B1; CYP1A1;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
ATP-binding cassette	ABCC1	Multidrug resistance-associated protein 1	P33527	CHEMBL3004
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Enzyme_unclassified	RECQL	ATP-dependent DNA helicase Q1	P46063	CHEMBL1293236
Enzyme_unclassified	PLA2G1B	Phospholipase A2 group 1B	P04054	CHEMBL4426
Enzyme_unclassified	HSD11B1	11-beta-hydroxysteroid dehydrogenase 1	P28845	CHEMBL4235
Enzyme_unclassified	AKR1B10	Aldo-keto reductase family 1 member B10	O60218	CHEMBL5983
Enzyme_unclassified	AKR1B1	Aldose reductase	P15121	CHEMBL1900
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	GAA	Lysosomal alpha-glucosidase	P10253	CHEMBL2608
Hydrolase	ATP12A	Potassium-transporting ATPase alpha chain 2	P54707	CHEMBL2933
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA13	Carbonic anhydrase XIII	Q8N1Q1	CHEMBL3912
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA7	Carbonic anhydrase VII	P43166	CHEMBL2326
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Nuclear hormone receptor subfamily 1 group F	RORC	Nuclear receptor ROR-gamma	P51449	CHEMBL1741186
Nuclear hormone receptor subfamily 1 group H	NR1H4	Bile acid receptor FXR	Q96RI1	CHEMBL2047
Peptide receptor (family A GPCR)	NMUR2	Neuromedin-U receptor 2	Q9GZQ4	CHEMBL1075144
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Protein Phosphatase	PTPN1	Protein-tyrosine phosphatase 1B	P18031	CHEMBL335
Protein Phosphatase	PTPN2	T-cell protein-tyrosine phosphatase	P17706	CHEMBL3807
Protein Phosphatase	ACP1	Low molecular weight phosphotyrosine protein phosphatase	P24666	CHEMBL4903
Protein Phosphatase	CDC25B	Dual specificity phosphatase Cdc25B	P30305	CHEMBL4804
Protein Phosphatase	PTPRF	Receptor-type tyrosine-protein phosphatase F (LAR)	P10586	CHEMBL3521
Small molecule receptor (family A GPCR)	GPBAR1	G-protein coupled bile acid receptor 1	Q8TDU6	CHEMBL5409
Small molecule receptor (family A GPCR)	ADRA2C	Alpha-2c adrenergic receptor	P18825	CHEMBL1916
Small molecule receptor (family A GPCR)	ADRA2A	Alpha-2a adrenergic receptor	P08913	CHEMBL1867
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	PAX8	Paired box protein Pax-8	Q06710	CHEMBL2362980

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	4.297E-11	9.356E-07	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	5.249E-09	3.810E-05	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	1.115E-08	4.966E-05	AKR1B1, AKR1B10, CYP1A1, CYP1A2, CYP1B1, HSD11B1, NPC1, NR1H4
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.497E-08	5.431E-05	CA1, CA12, CA13, CA7, CA9
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	6.483E-07	8.823E-04	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0035335; peptidyl-tyrosine dephosphorylation	9.178E-07	1.052E-03	ACP1, CDC25B, PTPN1, PTPN2, PTPRF
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	7.088E-06	6.431E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	9.415E-06	6.714E-03	CYP1A1, CYP1A2, CYP1B1
BP	GO:0009987; cellular process	GO:0038183; bile acid signaling pathway	9.558E-06	6.714E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	9.415E-06	6.714E-03	CYP1A1, CYP1A2, CYP1B1
MF	GO:0060089; molecular transducer activity	GO:0004938; alpha2-adrenergic receptor activity	9.558E-06	6.714E-03	ADRA2A, ADRA2C
MF	GO:0060089; molecular transducer activity	GO:0038181; bile acid receptor activity	9.558E-06	6.714E-03	GPBAR1, NR1H4
MF	GO:0003824; catalytic activity	GO:0016788; hydrolase activity, acting on ester bonds	4.835E-05	1.880E-02	ACHE, ACP1, CA1, CDC25B, PLA2G1B, PTPN1, PTPN2, PTPRF
CC	GO:0044464; cell part	GO:0005764; lysosome	1.269E-04	3.329E-02	AKR1B1, AKR1B10, GAA, NPC1, RAB9A

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	1.737E-04	2.687E-03	CYP1A1, CYP1B1
09150 Organismal Systems	09152 Endocrine system	hsa04913	Ovarian steroidogenesis	2.721E-04	2.687E-03	CYP1A1, CYP1B1
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	3.664E-04	2.687E-03	CYP1A1, CYP1B1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	5.802E-04	3.191E-03	CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	7.315E-04	3.219E-03	CYP1A1, CYP1B1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE;
NA: NA	Upper abdominal bloating	NA	ACHE;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; CDC25B;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases