Plant Name: Helichrysum italicum
Taxonomic Information:
Plant ID: NPO25148
Plant Latin Name: Helichrysum italicum
Taxonomy Genus: Helichrysum
Taxonomy Family: Asteraceae
Plant External Links:
NCBI TaxonomyDB:
261786
Plant-of-the-World-Online:
n.a.
Used in Medicines:
Country/Region:
Italy; GreeceTraditional Medicine System:
Geographical Distribution:
Italy; Greece
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: | CYP2C19; |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Cytochrome P450 family 2 | CYP2C19 | Cytochrome P450 2C19 | P33261 | CHEMBL3622 |
| Enzyme_unclassified | AKR1B10 | Aldo-keto reductase family 1 member B10 | O60218 | CHEMBL5983 |
| Enzyme_unclassified | AKR1B1 | Aldose reductase | P15121 | CHEMBL1900 |
| Unclassified | HTT | Huntingtin | P42858 | CHEMBL5514 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0008152; metabolic process | GO:0044597; daunorubicin metabolic process | 9.002E-07 | 6.300E-03 | AKR1B1, AKR1B10 |
| BP | GO:0008152; metabolic process | GO:0044598; doxorubicin metabolic process | 9.002E-07 | 6.300E-03 | AKR1B1, AKR1B10 |
| BP | GO:0008152; metabolic process | GO:0008202; steroid metabolic process | 8.185E-06 | 2.971E-02 | AKR1B1, AKR1B10, CYP2C19 |
| MF | GO:0003824; catalytic activity | GO:0004033; aldo-keto reductase (NADP) activity | 1.044E-05 | 3.246E-02 | AKR1B1, AKR1B10 |
| BP | GO:0008152; metabolic process | GO:0017144; drug metabolic process | 7.959E-05 | 1.333E-01 | AKR1B1, AKR1B10, CYP2C19 |
| CC | GO:0044464; cell part | GO:0005764; lysosome | 1.180E-03 | 5.103E-01 | AKR1B1, AKR1B10 |
| MF | GO:0003824; catalytic activity | GO:0001758; retinal dehydrogenase activity | 1.449E-03 | 5.440E-01 | AKR1B10 |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00040 | Pentose and glucuronate interconversions | 1.886E-05 | 6.915E-05 | AKR1B10, AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00052 | Galactose metabolism | 1.303E-05 | 6.915E-05 | AKR1B10, AKR1B1 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00561 | Glycerolipid metabolism | 5.114E-05 | 1.406E-04 | AKR1B10, AKR1B1 |
| 09100 Metabolism | 09101 Carbohydrate metabolism | hsa00051 | Fructose and mannose metabolism | 1.485E-05 | 6.915E-05 | AKR1B10, AKR1B1 |
| Unclassified | Unclassified | hsa01100 | Metabolic pathways | 9.049E-04 | 1.991E-03 | AKR1B10, AKR1B1, CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00590 | Arachidonic acid metabolism | 1.234E-02 | 1.888E-02 | CYP2C19 |
| 09100 Metabolism | 09103 Lipid metabolism | hsa00591 | Linoleic acid metabolism | 5.788E-03 | 1.061E-02 | CYP2C19 |
| 09100 Metabolism | 09111 Xenobiotics biodegradation and metabolism | hsa00982 | Drug metabolism - cytochrome P450 | 1.373E-02 | 1.888E-02 | CYP2C19 |
| 09150 Organismal Systems | 09156 Nervous system | hsa04726 | Serotonergic synapse | 2.221E-02 | 2.444E-02 | CYP2C19 |
| 09160 Human Diseases | 09161 Cancers | hsa05204 | Chemical carcinogenesis | 1.630E-02 | 1.992E-02 | CYP2C19 |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|---|---|---|
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetes | E23.2, N25.1 | AKR1B1; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Gout | M10 | AKR1B1; |
| H00-H59: Diseases of the eye and adnexa | Glaucoma | H40-H42 | AKR1B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic complication | E08-E13 | AKR1B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic cataract | E10.36, E11.36 | AKR1B1; |
| C00-D49: Neoplasms | Head and neck cancer | C07-C14, C32-C33 | AKR1B1; |
| M00-M99: Diseases of the musculoskeletal system and connective tissue | Rheumatoid arthritis | M05-M06 | AKR1B1; |
| E00-E89: Endocrine, nutritional and metabolic diseases | Diabetic neuropathy | E11.40 | AKR1B1; |
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
