CMAUP Plant Collective Molecular Activities

Plant Name: Heracleum yungningense

Taxonomic Information:

Plant ID: NPO25004
Plant Latin Name: Heracleum yungningense
Taxonomy Genus: Heracleum
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 473995
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Enzyme_unclassified	HSD17B10;
Transcription Factor	NFKB1;
Unclassified	MAPT; LMNA;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Transcription Factor	NFKB1	Nuclear factor NF-kappa-B p105 subunit	P19838	CHEMBL3251
Unclassified	MAPT	Microtubule-associated protein tau	P10636	CHEMBL1293224
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0008152; metabolic process	GO:1902894; negative regulation of pri-miRNA transcription from RNA polymerase II promoter	8.240E-06	1.226E-01	PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0050728; negative regulation of inflammatory response	1.126E-05	1.226E-01	NFKB1, PPARA, PPARD
BP	GO:0050896; response to stimulus	GO:0009628; response to abiotic stimulus	1.862E-05	1.352E-01	LMNA, MAPT, NFKB1, PPARA, PPARD
BP	GO:0009987; cellular process	GO:0009755; hormone-mediated signaling pathway	3.443E-05	1.609E-01	PPARA, PPARD, TSHR
BP	GO:0009987; cellular process	GO:0010743; regulation of macrophage derived foam cell differentiation	6.060E-05	1.982E-01	NFKB1, PPARA
MF	GO:0140110; transcription regulator activity	GO:0004879; nuclear receptor activity	1.748E-04	1.982E-01	PPARA, PPARD
MF	GO:0060089; molecular transducer activity	GO:0003707; steroid hormone receptor activity	2.538E-04	2.068E-01	PPARA, PPARD
CC	GO:0032991; macromolecular complex	GO:0033256; I-kappaB/NF-kappaB complex	2.896E-03	4.117E-01	NFKB1
CC	GO:0044464; cell part	GO:0030673; axolemma	6.609E-03	5.350E-01	MAPT
CC	GO:0043226; organelle	GO:0043231; intracellular membrane-bounded organelle	9.098E-03	6.350E-01	CYP3A4, HSD17B10, LMNA, MAPT, NFKB1, PPARA, PPARD

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	5.238E-05	3.824E-03	PPARA, NFKB1, TSHR
09160 Human Diseases	09161 Cancers	hsa05221	Acute myeloid leukemia	2.210E-04	6.087E-03	NFKB1, PPARD
09150 Organismal Systems	09152 Endocrine system	hsa04920	Adipocytokine signaling pathway	3.335E-04	6.087E-03	PPARA, NFKB1
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	3.241E-04	6.087E-03	PPARA, PPARD
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04931	Insulin resistance	8.066E-04	1.178E-02	PPARA, NFKB1
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.325E-03	1.382E-02	LMNA, NFKB1
09160 Human Diseases	09166 Endocrine and metabolic diseases	hsa04932	Non-alcoholic fatty liver disease (NAFLD)	1.539E-03	1.404E-02	PPARA, NFKB1
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.197E-03	1.382E-02	PPARA, NFKB1
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05010	Alzheimer's disease	1.900E-03	1.541E-02	MAPT, HSD17B10
09130 Environmental Information Processing	09132 Signal transduction	hsa04010	MAPK signaling pathway	4.310E-03	3.146E-02	MAPT, NFKB1

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Central nervous system disease	G00-G99	MAPT;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	MAPT;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	MAPT;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases