CMAUP Plant Collective Molecular Activities

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR;
Enzyme_unclassified	MTOR; GFER; HSD17B10; ALDH1A1;
Lyase	CA2; CA1; CA12; CA9; CA3; CA14; CA7; CA5A; CA6;
Aspartic protease	CTSD;
Cysteine protease	CASP1; CASP7;
Transcription Factor	TP53;
Unclassified	HTT; LMNA; THPO;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP1A2;

Detailed Information of Target Proteins

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Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Aspartic protease	CTSD	Cathepsin D	P07339	CHEMBL2581
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Enzyme_unclassified	MTOR	Serine/threonine-protein kinase mTOR	P42345	CHEMBL2842
Enzyme_unclassified	GFER	FAD-linked sulfhydryl oxidase ALR	P55789	CHEMBL1741189
Enzyme_unclassified	HSD17B10	Endoplasmic reticulum-associated amyloid beta-peptide-binding protein	Q99714	CHEMBL4159
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Lyase	CA2	Carbonic anhydrase II	P00918	CHEMBL205

Showing 1 to 10 of 24 entries

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Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

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GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0009987; cellular process	GO:0032849; positive regulation of cellular pH reduction	4.821E-06	8.748E-03	CA2, CA7
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	1.370E-18	1.492E-14	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	6.671E-17	3.632E-13	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	2.405E-05	2.862E-02	CYP1A2, CYP2C19
BP	GO:0050896; response to stimulus	GO:0014070; response to organic cyclic compound	2.760E-05	2.862E-02	CA2, CA9, CASP1, CASP7, CYP1A2, MTOR, TP53
MF	GO:0005488; binding	GO:0008270; zinc ion binding	4.412E-07	8.734E-04	CA1, CA12, CA2, CA3, CA5A, CA6, CA7, CA9, TP53
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	9.886E-24	2.153E-19	CA1, CA12, CA14, CA2, CA3, CA5A, CA6, CA7, CA9
MF	GO:0003824; catalytic activity	GO:0004064; arylesterase activity	2.405E-05	2.862E-02	CA1, CA2

Showing 1 to 8 of 8 entries

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Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

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Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	3.506E-23	3.120E-21	CA12, CA1, CA3, CA2, CA5A, CA7, CA6, CA9, CA14
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	5.966E-04	1.770E-02	CYP1A2, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	2.973E-03	3.306E-02	CYP1A2, ALDH1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	3.343E-03	3.306E-02	CYP1A2, CYP2C19
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	2.595E-05	1.155E-03	CASP7, LMNA, TP53, CTSD
09160 Human Diseases	09161 Cancers	hsa05214	Glioma	2.973E-03	3.306E-02	TP53, MTOR
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05014	Amyotrophic lateral sclerosis (ALS)	1.842E-03	3.306E-02	CASP1, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05134	Legionellosis	2.139E-03	3.306E-02	CASP7, CASP1
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.156E-03	3.306E-02	TP53, MTOR
09160 Human Diseases	09167 Infectious diseases	hsa05133	Pertussis	3.936E-03	3.503E-02	CASP7, CASP1

Showing 1 to 10 of 10 entries

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Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

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ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
C00-D49: Neoplasms	Solid tumours	C00-D48	CA9;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
C00-D49: Neoplasms	Breast cancer	C50	CA9;
C00-D49: Neoplasms	Cancer	C00-C96	CA9;

Showing 1 to 6 of 6 entries

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Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases

Plant Name: Jacobaea cannabifolia

Taxonomic Information:

Plant External Links:

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

List of Human Cytochrome P450 Enzymes Affected by the Plant

Detailed Information of Target Proteins

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

>> Profiles of ingredients and activity landscape

>> Collective molecular activities profile at 10μM cutoff

>> Targets derived from weak experimental activities