CMAUP Plant Collective Molecular Activities

Plant Name: Polyalthia nemoralis

Taxonomic Information:

Plant ID: NPO24893
Plant Latin Name: Polyalthia nemoralis
Taxonomy Genus: Polyalthia
Taxonomy Family: Annonaceae

Plant External Links:

NCBI TaxonomyDB: n.a.
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China

Traditional Medicine System:

TCM

Geographical Distribution:

China

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Peptide receptor (family A GPCR)	TSHR; NPSR1;
Enzyme_unclassified	TDP1; ALOX15; ALDH1A1; USP2;
Lyase	CA12; CA1; CA5A; CA5B; CA6;
Nuclear hormone receptor subfamily 1 group C	PPARA; PPARD;
Lysine demethylase	KDM4E;
Toll-like and Il-1 receptors	TLR2;
Transcription Factor	HIF1A; TP53;
Unclassified	HTT; LMNA; FABP3; FABP5; FABP2; FABP4;
Methyl-lysine/arginine binding protein	SMN1;SMN2;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 10μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP3A4;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cytochrome P450 family 3	CYP3A4	Cytochrome P450 3A4	P08684	CHEMBL340
Enzyme_unclassified	TDP1	Tyrosyl-DNA phosphodiesterase 1	Q9NUW8	CHEMBL1075138
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA1	Carbonic anhydrase I	P00915	CHEMBL261
Lyase	CA5A	Carbonic anhydrase VA	P35218	CHEMBL4789
Lyase	CA5B	Carbonic anhydrase VB	Q9Y2D0	CHEMBL3969
Lyase	CA6	Carbonic anhydrase VI	P23280	CHEMBL3025
Lysine demethylase	KDM4E	Lysine-specific demethylase 4D-like	B2RXH2	CHEMBL1293226
Methyl-lysine/arginine binding protein	SMN1;SMN2	Survival motor neuron protein	Q16637	CHEMBL1293232
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Nuclear hormone receptor subfamily 1 group C	PPARD	Peroxisome proliferator-activated receptor delta	Q03181	CHEMBL3979
Peptide receptor (family A GPCR)	TSHR	Thyroid stimulating hormone receptor	P16473	CHEMBL1963
Peptide receptor (family A GPCR)	NPSR1	Neuropeptide S receptor	Q6W5P4	CHEMBL5162
Toll-like and Il-1 receptors	TLR2	Toll-like receptor 2	O60603	CHEMBL4163
Transcription Factor	HIF1A	Hypoxia-inducible factor 1 alpha	Q16665	CHEMBL4261
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674
Unclassified	FABP2	Fatty acid binding protein intestinal	P12104	CHEMBL4879
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083

Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	8.740E-12	1.903E-07	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0006730; one-carbon metabolic process	1.077E-09	7.814E-06	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	3.079E-09	1.676E-05	CA1, CA12, CA5A, CA5B, CA6
BP	GO:0008152; metabolic process	GO:0019433; triglyceride catabolic process	3.200E-08	9.953E-05	FABP2, FABP3, FABP4, FABP5
BP	GO:0050896; response to stimulus	GO:0042060; wound healing	3.264E-06	2.843E-03	ALOX15, PPARA, PPARD, TP53
BP	GO:0008152; metabolic process	GO:0009299; mRNA transcription	4.882E-06	3.938E-03	HIF1A, PPARD, TP53
MF	GO:0005488; binding	GO:0008270; zinc ion binding	7.563E-06	5.147E-03	CA1, CA12, CA5A, CA5B, CA6, PPARA, PPARD, TP53
BP	GO:0009987; cellular process	GO:0071456; cellular response to hypoxia	1.082E-05	6.733E-03	HIF1A, LMNA, PPARD, TP53
MF	GO:0005488; binding	GO:0097371; MDM2/MDM4 family protein binding	3.644E-05	1.889E-02	PPARA, TP53
MF	GO:0005488; binding	GO:0036041; long-chain fatty acid binding	9.511E-05	4.142E-02	FABP3, PPARD
MF	GO:0005488; binding	GO:0002039; p53 binding	1.116E-04	4.674E-02	HIF1A, HTT, TP53
CC	GO:0043226; organelle	GO:0097504; Gemini of coiled bodies	1.140E-04	4.685E-02	SMN1, SMN2

Enriched KEGG Pathways of Target Proteins (Activity≤10μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	1.511E-11	1.194E-09	CA12, CA1, CA5B, CA5A, CA6
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	2.944E-10	1.163E-08	FABP2, FABP3, FABP4, FABP5, PPARA, PPARD
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	6.457E-04	1.700E-02	ALOX15, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05205	Proteoglycans in cancer	2.255E-03	3.787E-02	TP53, HIF1A, TLR2
09150 Organismal Systems	09152 Endocrine system	hsa04923	Regulation of lipolysis in adipocytes	2.397E-03	3.787E-02	FABP4, TSHR
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	3.214E-03	3.850E-02	ALDH1A1, CYP3A4
09160 Human Diseases	09161 Cancers	hsa05230	Central carbon metabolism in cancer	3.411E-03	3.850E-02	TP53, HIF1A
09160 Human Diseases	09167 Infectious diseases	hsa05160	Hepatitis C	1.285E-02	8.654E-02	PPARA, TP53
09160 Human Diseases	09167 Infectious diseases	hsa05162	Measles	1.341E-02	8.654E-02	TP53, TLR2
09160 Human Diseases	09167 Infectious diseases	hsa05161	Hepatitis B	1.534E-02	8.654E-02	TP53, TLR2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnostic test to differentiate primary and secondary hypothyroidism	W88	TSHR;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Cancer	C00-C96	TP53;
C00-D49: Neoplasms	Thyroid cancer	C73	TSHR;
C00-D49: Neoplasms	Thyroid cancer diagnosis	C73	TSHR;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases