CMAUP Plant Collective Molecular Activities

Plant Name: Datura metel

Taxonomic Information:

Plant ID: NPO24850
Plant Latin Name: Datura metel
Taxonomy Genus: Datura
Taxonomy Family: Solanaceae

Plant External Links:

NCBI TaxonomyDB: 35625
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

China; India

Traditional Medicine System:

Sowa-Rigpa; Indian Folk; Unani; Siddha; Ayurveda; TCM; Homeopathy

Medicinal Functions:

Anaesthetic; Anodyne; Antiasthmatic; Antispasmodic; Antitussive; Hallucinogenic; Hypnotic; Mydriatic

Geographical Distribution:

India; China

Example Image

Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	FFAR1; FFAR4; CHRM1; CHRM2; CHRM3; CHRM5;
Protein Kinase	MAPK1;
Nuclear hormone receptor subfamily 1 group C	PPARA;
Enzyme_unclassified	ALOX15;
Unclassified	FABP3; LMNA; FABP5;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Enzyme_unclassified	ALOX15	Arachidonate 15-lipoxygenase	P16050	CHEMBL2903
Nuclear hormone receptor subfamily 1 group C	PPARA	Peroxisome proliferator-activated receptor alpha	Q07869	CHEMBL239
Protein Kinase	MAPK1	MAP kinase ERK2	P28482	CHEMBL4040
Small molecule receptor (family A GPCR)	FFAR1	Free fatty acid receptor 1	O14842	CHEMBL4422
Small molecule receptor (family A GPCR)	FFAR4	G-protein coupled receptor 120	Q5NUL3	CHEMBL5339
Small molecule receptor (family A GPCR)	CHRM1	Muscarinic acetylcholine receptor M1	P11229	CHEMBL216
Small molecule receptor (family A GPCR)	CHRM2	Muscarinic acetylcholine receptor M2	P08172	CHEMBL211
Small molecule receptor (family A GPCR)	CHRM3	Muscarinic acetylcholine receptor M3	P20309	CHEMBL245
Small molecule receptor (family A GPCR)	CHRM5	Muscarinic acetylcholine receptor M5	P08912	CHEMBL2035
Unclassified	FABP3	Fatty acid binding protein muscle	P05413	CHEMBL3344
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP5	Fatty acid binding protein epidermal	Q01469	CHEMBL3674

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
BP	GO:0050896; response to stimulus	GO:0007197; adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	4.267E-13	4.646E-09	CHRM1, CHRM2, CHRM3, CHRM5
MF	GO:0060089; molecular transducer activity	GO:0016907; G-protein coupled acetylcholine receptor activity	4.267E-13	4.646E-09	CHRM1, CHRM2, CHRM3, CHRM5
BP	GO:0050896; response to stimulus	GO:0007207; phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	1.280E-12	9.288E-09	CHRM1, CHRM2, CHRM3, CHRM5
BP	GO:0023052; signaling	GO:0007271; synaptic transmission, cholinergic	1.487E-09	4.047E-06	CHRM1, CHRM2, CHRM3, CHRM5
MF	GO:0005488; binding	GO:0005504; fatty acid binding	5.313E-07	6.349E-04	FABP3, FABP5, FFAR4
MF	GO:0003824; catalytic activity	GO:0004435; phosphatidylinositol phospholipase C activity	5.313E-07	6.349E-04	CHRM1, CHRM3, CHRM5
BP	GO:0032501; multicellular organismal process	GO:0046541; saliva secretion	3.534E-06	2.731E-03	CHRM1, CHRM3
CC	GO:0044456; synapse part	GO:0043679; axon terminus	4.719E-06	3.425E-03	CHRM1, CHRM2, CHRM3
CC	GO:0044456; synapse part	GO:0045211; postsynaptic membrane	6.396E-06	4.220E-03	CHRM1, CHRM2, CHRM3, CHRM5
CC	GO:0045202; synapse	GO:0032279; asymmetric synapse	9.886E-06	5.520E-03	CHRM2, CHRM3
MF	Unclassified;	GO:0004872; receptor activity	1.193E-05	6.492E-03	CHRM1, CHRM2, CHRM3, CHRM5, FFAR1, FFAR4, PPARA
BP	Unclassified;	GO:0003056; regulation of vascular smooth muscle contraction	1.271E-05	6.748E-03	CHRM1, CHRM3

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09150 Organismal Systems	09156 Nervous system	hsa04725	Cholinergic synapse	3.692E-09	3.840E-07	CHRM2, CHRM3, CHRM1, CHRM5, MAPK1
09140 Cellular Processes	09142 Cell motility	hsa04810	Regulation of actin cytoskeleton	9.973E-08	5.186E-06	CHRM2, CHRM3, CHRM1, CHRM5, MAPK1
09130 Environmental Information Processing	09132 Signal transduction	hsa04020	Calcium signaling pathway	2.969E-06	1.029E-04	CHRM2, CHRM3, CHRM1, CHRM5
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	4.423E-06	1.150E-04	CHRM2, CHRM1, MAPK1, PPARA
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	1.633E-05	2.831E-04	CHRM2, CHRM3, CHRM1, CHRM5
09150 Organismal Systems	09152 Endocrine system	hsa03320	PPAR signaling pathway	8.456E-06	1.759E-04	FABP3, FABP5, PPARA

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
I00-I99: Diseases of the circulatory system	Cardiovascular disorder	I00-I99	CHRM2;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Diagnosing bronchial hyperreactivity	W88	CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	CHRM5;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	FFAR1;
G00-G99: Diseases of the nervous system G00-G99	Central and peripheral nervous diseases	G96.9	CHRM5;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	CHRM1; CHRM2; CHRM3;
C00-D49: Neoplasms	Cancer	C00-C96	MAPK1;
I00-I99: Diseases of the circulatory system	Restenosis	I51.89	MAPK1;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	CHRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Amnesia	F04	CHRM5;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	CHRM1; CHRM5;
K00-K95: Diseases of the digestive system	Colitis	K50-K52	CHRM5;
K00-K95: Diseases of the digestive system	Peptic ulcer	K25-K27	CHRM1; CHRM2;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	CHRM3;
J00-J99: Diseases of the respiratory system	Respiratory disease	J00-J99	CHRM3;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Anesthesia	R20.0	CHRM1;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	CHRM1; CHRM3; CHRM5;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Postoperative nausea and vomiting	R11	CHRM3;
G00-G99: Diseases of the nervous system G00-G99	Brain diseases	G00-G99	CHRM5;
NA: NA	Schizoaffective disorders	NA	CHRM1;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Sjogren's syndrome	M35.0	CHRM3;
NA: NA	Spasms	NA	CHRM3;
C00-D49: Neoplasms	Solid tumours	C00-D48	MAPK1;
NA: NA	Addiction	NA	CHRM2;
NA: NA	Dystonia	NA	CHRM1;
K00-K95: Diseases of the digestive system	Stomach ulcer	K25-K27	CHRM1; CHRM5;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Stabilize muscle contractions	M00-M99	CHRM2;
N00-N99: Diseases of the genitourinary system	Dysmenorrhea	N94.4-N94.6	CHRM5;
N00-N99: Diseases of the genitourinary system	Overactive bladder	N32.81	CHRM3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	CHRM1; CHRM5;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	CHRM1; CHRM2;
A00-B99: Certain infectious and parasitic diseases	Irritable bowel syndrome	A09, K58, K59.1	CHRM1; CHRM5;
C00-D49: Neoplasms	Overactive bladder disorder	C67, N32.81	CHRM1; CHRM3;
NA: NA	Functional bowel syndrome	NA	CHRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	CHRM2;
E00-E89: Endocrine, nutritional and metabolic diseases	Non-insulin dependent diabetes	E11.9	FFAR1;
I00-I99: Diseases of the circulatory system	Heart failure	I50	CHRM2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	CHRM1;
I00-I99: Diseases of the circulatory system	Neurological disease	I21, I22, R52, R52.1-R52.2, R60.9, G89	CHRM1; CHRM5;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	CHRM1; CHRM3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	CHRM1;
L00-L99: Diseases of the skin and subcutaneous tissue	Seborrhea	L21	CHRM3;
NA: NA	Extrapyramidal disorders secondary to neuroleptic drug therapy	NA	CHRM1;
NA: NA	Excessive sweating	NA	CHRM1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Visceral spasms	R25.2	CHRM1;
NA: NA	Abdominal stomach pain	NA	CHRM1;
J00-J99: Diseases of the respiratory system	Obstructive lung diseases	J40-J44, J47	CHRM3;
J00-J99: Diseases of the respiratory system	Asthma	J45	CHRM2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	FFAR1;
N00-N99: Diseases of the genitourinary system	Urinary incontinence	N39.3, N39.4, R32	CHRM1; CHRM2; CHRM3; CHRM5;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases