Plant Name: Schisandra rubriflora
Taxonomic Information:
Plant ID: NPO24804
Plant Latin Name: Schisandra rubriflora
Taxonomy Genus: Schisandra
Taxonomy Family: Schisandraceae
Plant External Links:
NCBI TaxonomyDB:
124791
Plant-of-the-World-Online:
n.a.
Example Image
Geographical Distribution
See the Plant Occurrence Worldwide with Latitude and Longitude Available
Collective Molecular Activities of the Plant
List of Human Proteins Collectively Targeted by the Plant
Click Gene ID to Access Activity Profile of Individual Target
List of Human Cytochrome P450 Enzymes Affected by the Plant
Click Gene ID to Access Activity Profile of Individual Enzyme
| Cytochrome P450 Enzymes: |
|---|
Detailed Information of Target Proteins
| Protein Class | Gene ID | Protein Name | Uniprot ID | Target ChEMBL ID |
|---|---|---|---|---|
| Enzyme_unclassified | TDP1 | Tyrosyl-DNA phosphodiesterase 1 | Q9NUW8 | CHEMBL1075138 |
| Protein Kinase | ATR | Serine-protein kinase ATR | Q13535 | CHEMBL5024 |
Enrichment of Gene Ontology of Target Proteins (Activity≤10μM)
Detailed Information of Enriched Gene Ontolgy
| GO Type | GO Category | Enriched GO Terms | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|
| BP | GO:0051179; localization | GO:0097695; establishment of macromolecular complex localization to telomere | 2.071E-04 | 7.515E-01 | ATR |
| BP | GO:0051179; localization | GO:0097694; establishment of RNA localization to telomere | 2.071E-04 | 7.515E-01 | ATR |
| BP | GO:0071840; cellular component organization or biogenesis | GO:1904884; positive regulation of telomerase catalytic core complex assembly | 2.071E-04 | 7.515E-01 | ATR |
| BP | GO:0065007; biological regulation | GO:0032206; positive regulation of telomere maintenance | 5.170E-03 | 1.000E+00 | ATR |
| BP | GO:0050896; response to stimulus | GO:2001022; positive regulation of response to DNA damage stimulus | 7.957E-03 | 1.000E+00 | ATR |
| BP | GO:0009987; cellular process | GO:1900034; regulation of cellular response to heat | 8.060E-03 | 1.000E+00 | ATR |
| CC | GO:0043226; organelle | GO:0000784; nuclear chromosome, telomeric region | 1.352E-02 | 1.000E+00 | ATR |
| MF | GO:0003824; catalytic activity | GO:0004674; protein serine/threonine kinase activity | 4.636E-02 | 1.000E+00 | ATR |
Enriched KEGG Pathways of Target Proteins (Activity≤10μM)
Top 10 KEGG Pathways (ordered by adjusted p-value)
Detailed Information of Enriched KEGG Pathways
| Pathway Category Top Level | Pathway Category Second Level | Pathway ID | Pathway Name | p-Value | Adjusted p-Value | Enriched Genes |
|---|---|---|---|---|---|---|
| 09120 Genetic Information Processing | 09124 Replication and repair | hsa03460 | Fanconi anemia pathway | 5.293E-03 | 1.378E-02 | ATR |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04115 | p53 signaling pathway | 6.888E-03 | 1.378E-02 | ATR |
| 09140 Cellular Processes | 09143 Cell growth and death | hsa04110 | Cell cycle | 1.236E-02 | 1.648E-02 | ATR |
| 09160 Human Diseases | 09167 Infectious diseases | hsa05166 | HTLV-I infection | 2.563E-02 | 2.563E-02 | ATR |
Human Diseases Associated with the Target Proteins of the Plant
Detailed Information of Human Diseases
| ICD10 Disease Category | Disease Name | ICD10 Code | Associated Disease Targets (Association Ref: TTD database) |
|---|
>> Profiles of ingredients and activity landscape
>> Targets derived from weak experimental activities
