CMAUP Plant Collective Molecular Activities

Plant Name: Angelica dahurica

Taxonomic Information:

Plant ID: NPO24758
Plant Latin Name: Angelica dahurica
Taxonomy Genus: Angelica
Taxonomy Family: Apiaceae

Plant External Links:

NCBI TaxonomyDB: 48101
Plant-of-the-World-Online: n.a.

Used in Medicines:

Country/Region:

South Korea

Traditional Medicine System:

Kampo

Medicinal Functions:

Analgesic; Antibacterial; Antidote; Carminative; Diaphoretic; Poultice; Stimulant

Geographical Distribution:

South Korea

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Geographical Distribution

See the Plant Occurrence Worldwide with Latitude and Longitude Available

Collective Molecular Activities of the Plant

List of Human Proteins Collectively Targeted by the Plant

Target Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Target

Target Class	Target Proteins
Small molecule receptor (family A GPCR)	ADORA3; ADORA2A; ADORA1; DRD1; DRD2;
Hydrolase	ACHE;
Enzyme_unclassified	ADK; ALDH1A1; USP2; BRCA1; POLB;
Lyase	CA12; CA9; CA14;
Cysteine protease	CASP1; CASP7;
Transcription Factor	TP53;
Plant homeodomain	KMT2A;
Unclassified	NPC1; HTT; RAB9A; LMNA; FABP4; HBB; THPO;

List of Human Cytochrome P450 Enzymes Affected by the Plant

Activity Range: ≤ 1μM
Click Gene ID to Access Activity Profile of Individual Enzyme

Cytochrome P450 Enzymes:	CYP2C19; CYP2C9; CYP1A2; CYP2A6; CYP1B1; CYP1A1; CYP2A13; CYP2D6;

Detailed Information of Target Proteins

Protein Class	Gene ID	Protein Name	Uniprot ID	Target ChEMBL ID
Cysteine protease	CASP1	Caspase-1	P29466	CHEMBL4801
Cysteine protease	CASP7	Caspase-7	P55210	CHEMBL3468
Cytochrome P450 family 1	CYP1A2	Cytochrome P450 1A2	P05177	CHEMBL3356
Cytochrome P450 family 1	CYP1B1	Cytochrome P450 1B1	Q16678	CHEMBL4878
Cytochrome P450 family 1	CYP1A1	Cytochrome P450 1A1	P04798	CHEMBL2231
Cytochrome P450 family 2	CYP2C19	Cytochrome P450 2C19	P33261	CHEMBL3622
Cytochrome P450 family 2	CYP2C9	Cytochrome P450 2C9	P11712	CHEMBL3397
Cytochrome P450 family 2	CYP2A6	Cytochrome P450 2A6	P11509	CHEMBL5282
Cytochrome P450 family 2	CYP2A13	Cytochrome P450 2A13	Q16696	CHEMBL3542436
Cytochrome P450 family 2	CYP2D6	Cytochrome P450 2D6	P10635	CHEMBL289
Enzyme_unclassified	ADK	Adenosine kinase	P55263	CHEMBL3589
Enzyme_unclassified	ALDH1A1	Aldehyde dehydrogenase 1A1	P00352	CHEMBL3577
Enzyme_unclassified	USP2	Ubiquitin carboxyl-terminal hydrolase 2	O75604	CHEMBL1293227
Enzyme_unclassified	BRCA1	Breast cancer type 1 susceptibility protein	P38398	CHEMBL5990
Enzyme_unclassified	POLB	DNA polymerase beta	P06746	CHEMBL2392
Hydrolase	ACHE	Acetylcholinesterase	P22303	CHEMBL220
Lyase	CA12	Carbonic anhydrase XII	O43570	CHEMBL3242
Lyase	CA9	Carbonic anhydrase IX	Q16790	CHEMBL3594
Lyase	CA14	Carbonic anhydrase XIV	Q9ULX7	CHEMBL3510
Plant homeodomain	KMT2A	Histone-lysine N-methyltransferase MLL	Q03164	CHEMBL1293299
Small molecule receptor (family A GPCR)	ADORA3	Adenosine A3 receptor	P0DMS8	CHEMBL256
Small molecule receptor (family A GPCR)	ADORA2A	Adenosine A2a receptor	P29274	CHEMBL251
Small molecule receptor (family A GPCR)	ADORA1	Adenosine A1 receptor	P30542	CHEMBL226
Small molecule receptor (family A GPCR)	DRD1	Dopamine D1 receptor	P21728	CHEMBL2056
Small molecule receptor (family A GPCR)	DRD2	Dopamine D2 receptor	P14416	CHEMBL217
Transcription Factor	TP53	Cellular tumor antigen p53	P04637	CHEMBL4096
Unclassified	NPC1	Niemann-Pick C1 protein	O15118	CHEMBL1293277
Unclassified	HTT	Huntingtin	P42858	CHEMBL5514
Unclassified	RAB9A	Ras-related protein Rab-9A	P51151	CHEMBL1293294
Unclassified	LMNA	Prelamin-A/C	P02545	CHEMBL1293235
Unclassified	FABP4	Fatty acid binding protein adipocyte	P15090	CHEMBL2083
Unclassified	HBB	Hemoglobin beta chain	P68871	CHEMBL4331
Unclassified	THPO	Thrombopoietin	P40225	CHEMBL1293256

Enrichment of Gene Ontology of Target Proteins (Activity≤1μM)

Detailed Information of Enriched Gene Ontolgy

GO Type	GO Category	Enriched GO Terms	p-Value	Adjusted p-Value	Enriched Genes
MF	GO:0005488; binding	GO:0020037; heme binding	6.248E-13	3.401E-09	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, HBB
BP	GO:0008152; metabolic process	GO:0097267; omega-hydroxylase P450 pathway	2.654E-12	8.216E-09	CYP1A1, CYP1A2, CYP1B1, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0005506; iron ion binding	4.762E-12	8.785E-09	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, HBB
MF	GO:0003824; catalytic activity	GO:0008395; steroid hydroxylase activity	1.998E-11	3.108E-08	CYP1A1, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0016098; monoterpenoid metabolic process	1.056E-10	1.533E-07	CYP1A2, CYP2C19, CYP2C9, CYP2D6
BP	GO:0008152; metabolic process	GO:0009804; coumarin metabolic process	2.461E-10	2.820E-07	CYP1A1, CYP2A13, CYP2A6, CYP2D6
MF	GO:0003824; catalytic activity	GO:0070330; aromatase activity	3.489E-10	3.453E-07	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2D6
BP	GO:0050896; response to stimulus	GO:0042738; exogenous drug catabolic process	3.460E-09	2.354E-06	CYP1A2, CYP2A6, CYP2C19, CYP2C9
BP	GO:0008152; metabolic process	GO:0008202; steroid metabolic process	6.725E-09	4.184E-06	CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2C9, CYP2D6, NPC1
MF	GO:0003824; catalytic activity	GO:0008392; arachidonic acid epoxygenase activity	1.653E-08	9.731E-06	CYP2A13, CYP2A6, CYP2C19, CYP2C9
MF	GO:0060089; molecular transducer activity	GO:0001609; G-protein coupled adenosine receptor activity	1.583E-07	8.205E-05	ADORA1, ADORA2A, ADORA3
BP	GO:0009987; cellular process	GO:0001973; adenosine receptor signaling pathway	3.790E-07	1.794E-04	ADORA1, ADORA2A, ADORA3
BP	GO:0051179; localization	GO:0015701; bicarbonate transport	9.130E-07	3.808E-04	CA12, CA14, CA9, HBB
BP	GO:0050896; response to stimulus	GO:0010038; response to metal ion	9.269E-07	3.808E-04	CYP1A1, CYP1A2, DRD2, FABP4, KMT2A, NPC1, TP53
BP	GO:0008152; metabolic process	GO:0070989; oxidative demethylation	9.890E-07	3.988E-04	CYP1A2, CYP2C9, CYP2D6
BP	GO:0050896; response to stimulus	GO:0060134; prepulse inhibition	1.284E-06	4.994E-04	ADORA2A, DRD1, DRD2
CC	GO:0016020; membrane	GO:0005789; endoplasmic reticulum membrane	1.965E-06	7.251E-04	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, DRD1, RAB9A
MF	GO:0003824; catalytic activity	GO:0004089; carbonate dehydratase activity	2.038E-06	7.276E-04	CA12, CA14, CA9
MF	GO:0003824; catalytic activity	GO:0008389; coumarin 7-hydroxylase activity	2.830E-06	9.482E-04	CYP2A13, CYP2A6
BP	GO:0050896; response to stimulus	GO:0001666; response to hypoxia	4.483E-06	1.326E-03	ADORA1, CASP1, CYP1A1, DRD2, LMNA, TP53
BP	GO:0050896; response to stimulus	GO:0055093; response to hyperoxia	5.917E-06	1.588E-03	CYP1A1, POLB, TP53
BP	GO:0065007; biological regulation	GO:0048167; regulation of synaptic plasticity	5.982E-06	1.588E-03	ADORA1, ADORA2A, DRD1, DRD2, KMT2A
BP	GO:0008152; metabolic process	GO:0009404; toxin metabolic process	7.860E-06	1.994E-03	CYP1A1, CYP1A2, CYP1B1
CC	GO:0044464; cell part	GO:0099056; integral component of presynaptic membrane	8.482E-06	2.052E-03	ADORA1, ADORA2A
BP	GO:0050896; response to stimulus	GO:0001975; response to amphetamine	1.150E-05	2.636E-03	ADORA2A, DRD1, DRD2
BP	GO:0050896; response to stimulus	GO:0009611; response to wounding	1.243E-05	2.761E-03	ACHE, ADORA3, CYP1A1, DRD2, TP53
BP	GO:0007610; behavior	GO:0007628; adult walking behavior	1.292E-05	2.814E-03	DRD1, DRD2, NPC1
BP	GO:0050896; response to stimulus	GO:2001025; positive regulation of response to drug	1.292E-05	2.814E-03	ADORA2A, DRD2, KMT2A
BP	GO:0008152; metabolic process	GO:0018894; dibenzo-p-dioxin metabolic process	1.695E-05	3.425E-03	CYP1A1, CYP1A2
MF	GO:0003824; catalytic activity	GO:0034875; caffeine oxidase activity	1.695E-05	3.425E-03	CYP1A2, CYP2C9
BP	GO:0008283; cell proliferation	GO:0008285; negative regulation of cell proliferation	1.850E-05	3.629E-03	ADORA1, ADORA2A, ADORA3, CYP1B1, DRD2, KMT2A, LMNA, TP53
BP	GO:0032501; multicellular organismal process	GO:0001659; temperature homeostasis	1.977E-05	3.843E-03	ADORA1, DRD1, DRD2
BP	GO:0023052; signaling	GO:0032228; regulation of synaptic transmission, GABAergic	2.178E-05	4.054E-03	ADORA1, ADORA2A, DRD2
BP	GO:0009987; cellular process	GO:0071407; cellular response to organic cyclic compound	2.524E-05	4.619E-03	BRCA1, CASP7, CYP1A1, CYP1B1, DRD1, NPC1
BP	Unclassified;	GO:2000021; regulation of ion homeostasis	2.562E-05	4.649E-03	ADORA1, ADORA2A, DRD1, DRD2, HTT
BP	Unclassified;	GO:0021853; cerebral cortex GABAergic interneuron migration	2.821E-05	4.954E-03	DRD1, DRD2
BP	GO:0032501; multicellular organismal process	GO:0042321; negative regulation of circadian sleep/wake cycle, sleep	2.821E-05	4.954E-03	ADORA1, DRD2
BP	GO:0065007; biological regulation	GO:0065009; regulation of molecular function	3.962E-05	6.536E-03	ADORA1, ADORA2A, ADORA3, ALDH1A1, CASP1, CASP7, CYP1B1, CYP2D6, DRD1, DRD2, FABP4, HTT, KMT2A, RAB9A, THPO, TP53
BP	GO:0051179; localization	GO:0043270; positive regulation of ion transport	4.876E-05	7.750E-03	ADORA1, ADORA2A, DRD1, DRD2, HTT
BP	GO:0008152; metabolic process	GO:0009820; alkaloid metabolic process	5.912E-05	8.940E-03	CYP1A2, CYP2D6
BP	GO:0065007; biological regulation	GO:0042592; homeostatic process	6.140E-05	9.158E-03	ADORA1, CA12, DRD1, DRD2, FABP4, HTT, KMT2A, NPC1, POLB, TP53
CC	GO:0016020; membrane	GO:0031090; organelle membrane	6.687E-05	9.838E-03	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C9, CYP2D6, DRD1, DRD2, HTT, LMNA, NPC1, RAB9A
BP	GO:0051179; localization	GO:0002793; positive regulation of peptide secretion	6.763E-05	9.884E-03	ACHE, ADORA1, ADORA2A, CASP1, DRD2
BP	GO:0008152; metabolic process	GO:0019373; epoxygenase P450 pathway	2.457E-15	5.351E-11	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2A6, CYP2C19, CYP2C9
MF	GO:0005488; binding	GO:0019825; oxygen binding	5.975E-15	6.506E-11	CYP1A1, CYP1A2, CYP1B1, CYP2A13, CYP2C19, CYP2C9, CYP2D6, HBB

Enriched KEGG Pathways of Target Proteins (Activity≤1μM)

Top 10 KEGG Pathways (ordered by adjusted p-value)

Detailed Information of Enriched KEGG Pathways

Pathway Category Top Level	Pathway Category Second Level	Pathway ID	Pathway Name	p-Value	Adjusted p-Value	Enriched Genes
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00980	Metabolism of xenobiotics by cytochrome P450	2.545E-11	2.316E-09	CYP2C9, CYP2A6, CYP2A13, CYP2D6, CYP1A2, CYP1A1, CYP1B1
09160 Human Diseases	09161 Cancers	hsa05204	Chemical carcinogenesis	5.877E-11	2.674E-09	CYP2C9, CYP2A6, CYP2A13, CYP1A2, CYP1A1, CYP1B1, CYP2C19
09100 Metabolism	09108 Metabolism of cofactors and vitamins	hsa00830	Retinol metabolism	6.857E-08	2.080E-06	CYP2C9, CYP2A6, CYP1A2, ALDH1A1, CYP1A1
09100 Metabolism	09111 Xenobiotics biodegradation and metabolism	hsa00982	Drug metabolism - cytochrome P450	9.287E-08	2.113E-06	CYP2C9, CYP2A6, CYP2D6, CYP1A2, CYP2C19
09100 Metabolism	09105 Amino acid metabolism	hsa00380	Tryptophan metabolism	3.879E-05	4.412E-04	CYP1A2, CYP1A1, CYP1B1
09130 Environmental Information Processing	09133 Signaling molecules and interaction	hsa04080	Neuroactive ligand-receptor interaction	8.491E-05	8.586E-04	ADORA2A, ADORA3, ADORA1, DRD1, DRD2
09100 Metabolism	09103 Lipid metabolism	hsa00591	Linoleic acid metabolism	1.452E-05	2.203E-04	CYP2C9, CYP1A2, CYP2C19
09100 Metabolism	09102 Energy metabolism	hsa00910	Nitrogen metabolism	2.739E-06	4.986E-05	CA12, CA9, CA14
09130 Environmental Information Processing	09132 Signal transduction	hsa04024	cAMP signaling pathway	3.104E-04	2.568E-03	ADORA2A, ADORA1, DRD1, DRD2
09100 Metabolism	09103 Lipid metabolism	hsa00140	Steroid hormone biosynthesis	1.187E-04	1.080E-03	CYP1A2, CYP1A1, CYP1B1
09150 Organismal Systems	09156 Nervous system	hsa04726	Serotonergic synapse	8.253E-04	6.258E-03	CYP2C9, CYP2D6, CYP2C19
09140 Cellular Processes	09143 Cell growth and death	hsa04210	Apoptosis	1.571E-03	9.923E-03	CASP7, LMNA, TP53
09130 Environmental Information Processing	09132 Signal transduction	hsa04071	Sphingolipid signaling pathway	1.008E-03	7.055E-03	ADORA3, ADORA1, TP53
09160 Human Diseases	09163 Neurodegenerative diseases	hsa05012	Parkinson's disease	1.636E-03	9.923E-03	ADORA2A, DRD1, DRD2
09100 Metabolism	09110 Biosynthesis of other secondary metabolites	hsa00232	Caffeine metabolism	2.632E-05	3.422E-04	CYP2A6, CYP1A2

Human Diseases Associated with the Target Proteins of the Plant

Detailed Information of Human Diseases

ICD10 Disease Category	Disease Name	ICD10 Code	Associated Disease Targets (Association Ref: TTD database)
C00-D49: Neoplasms	Oral cavity cancer	C00-C08	TP53;
I00-I99: Diseases of the circulatory system	Orthostatic hypotension	I95.1	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Hypertriglyceridemia	E78.1, E78.2, E78.3, I47-I49	ADORA1;
I00-I99: Diseases of the circulatory system	Hypertension	I10-I16	ADORA1; ADORA2A; DRD1; DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperlipidaemia	E78	ADORA1;
NA: NA	Inflammatory diseases	NA	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Neuropathic pain	G64, G90.0	ADORA1; ADORA2A;
NA: NA	Malignant essential hypertension	NA	DRD2;
NA: NA	Malignant phaeochromocytoma	NA	DRD2;
N00-N99: Diseases of the genitourinary system	Renal failure	N17, N18, N19	ADORA1;
C00-D49: Neoplasms	Renal cancer	C64	CA9;
I00-I99: Diseases of the circulatory system	Renal artery disease	I70.1	TP53;
J00-J99: Diseases of the respiratory system	Bronchitis	J20-J21, J42	DRD2;
C00-D49: Neoplasms	Cancer	C00-C96	ACHE; ADORA3; TP53; CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Carcinoid syndrome	E34.0	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Insomnia	F51.0, G47.0	CYP2D6; DRD2;
I00-I99: Diseases of the circulatory system	Pulmonary hypertension	I27.0, I27.2	DRD2;
W85-W99: Exposure to electric current, radiation and extreme ambient air temperature and pressure	Radionuclide imaging	W88	ADORA2A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Anxiety disorder	F32, F40-F42	ACHE; DRD2;
I00-I99: Diseases of the circulatory system	Angina pectoris	I20	DRD2;
I00-I99: Diseases of the circulatory system	Cardiotonic	I50	DRD2;
I00-I99: Diseases of the circulatory system	Cardiac disease	I00-I99	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Malaria	B54	CYP2D6; ADORA3;
C00-D49: Neoplasms	Breast cancer	C50	DRD2; CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychotic disorders	F20-F29	DRD1; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychiatric disorder	F01-F99	DRD1;
NA: NA	Benign prostatic hypertrophy	NA	DRD2;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Beta thalassemia	D56.1	HBB;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Bipolar disorder	F31, F40-F42	DRD2;
I00-I99: Diseases of the circulatory system	Hypotension	I95	DRD2;
M00-M99: Diseases of the musculoskeletal system and connective tissue	Rheumatoid arthritis	M05-M06	CASP1;
C00-D49: Neoplasms	Head and neck cancer	C07-C14, C32-C33	TP53;
H60-H95: Diseases of the ear and mastoid process	Hearing disorder	H90.5	TP53;
I00-I99: Diseases of the circulatory system	Heart failure	I50	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Type 2 diabetes	E11	DRD1;
S00-T88: Injury, poisoning and certain other consequences of external causes	Toxicity	T36-T50, T51-T65	TP53;
C00-D49: Neoplasms	Solid tumours	C00-D48	TP53; CA9;
E00-E89: Endocrine, nutritional and metabolic diseases	Hyperprolactinemia	E22.1	DRD2;
NA: NA	Hepatitis C virus infection	NA	ADORA3;
C00-D49: Neoplasms	Hematological malignancies	C81-C86	TP53;
NA: NA	Upper abdominal bloating	NA	ACHE;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Sexual dysfunction	F52	DRD2;
A00-B99: Certain infectious and parasitic diseases	Fungal infections	B35-B49	RAB9A;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Schizophrenia	F20	DRD1; DRD2;
A00-B99: Certain infectious and parasitic diseases	Sepsis	A40, A41	ADORA1;
G00-G99: Diseases of the nervous system G00-G99	Multiple scierosis	G35	ADORA1;
NA: NA	Vomiting	NA	DRD2;
NA: NA	Schizoaffective disorders	NA	DRD2;
K00-K95: Diseases of the digestive system	Gastrointestinal problems	K30-K31, Q40-Q41	DRD2;
NA: NA	Peripheral vasoconstriction	NA	DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poison intoxication	T36-T50	ACHE;
S00-T88: Injury, poisoning and certain other consequences of external causes	Poisoning due to pesticides and chemicals	T36-T50	ACHE;
K00-K95: Diseases of the digestive system	Xerostomia	K11.7, R68.2	ACHE;
J00-J99: Diseases of the respiratory system	Nasal congestion	J34.89	DRD2;
C00-D49: Neoplasms	Inflammatory disease	C11, C44, K75.9, M00-M25	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cognitive disorders	F01-F07, F04, F05, R41.3	ACHE; ADORA1; DRD1;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Major depressive disorder	F32, F33, M32	DRD2;
I00-I99: Diseases of the circulatory system	Cerebrovascular ischaemia	I61-I63	ADORA3; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Substance dependence	F10-F19	DRD1; DRD2;
I00-I99: Diseases of the circulatory system	Maintain blood pressure in hypotensive states	I10	DRD2;
I00-I99: Diseases of the circulatory system	Cardiac failure	I50	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Convulsions	R56.0	ADK;
I00-I99: Diseases of the circulatory system	Coronary disorder diagnosis	I20-I25	ADORA2A;
NA: NA	Corneal vascularity	NA	DRD2;
I00-I99: Diseases of the circulatory system	Cardiac arrhythmias	I47-I49	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Atrial fibrillation	E78, I48	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Autoimmune diabetes	E08-E13	ADORA1;
A00-B99: Certain infectious and parasitic diseases	Bacterial infections	A00-B99	CYP2C9; DRD2;
N00-N99: Diseases of the genitourinary system	Urinary dysfunction	N39.3-N39.4	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Migraine	G43	CYP2D6;
G00-G99: Diseases of the nervous system G00-G99	Migraine headaches	G43	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Mild cognitive impairment	F06.7	ACHE;
L00-L99: Diseases of the skin and subcutaneous tissue	Fibrosis	L90.5	DRD2; CASP1;
J00-J99: Diseases of the respiratory system	Asthma	J45	ADORA1; ADORA2A; DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Fatigue	R53	ADORA1;
NA: NA	False perceptions	NA	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Neurodegenerative disease	G30-G32	ACHE;
NA: NA	Itching	NA	DRD2;
I00-I99: Diseases of the circulatory system	Ischemia	I99.8	ADORA3;
I00-I99: Diseases of the circulatory system	Arteriosclerosis	I70	ADORA2A;
O00-O9A: Pregnancy, childbirth and the puerperium	Excessive bleeding following childbirth and spontaneous or elective abortion	O04	DRD1;
C00-D49: Neoplasms	Non-small cell lung cancer	C33-C34	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Inflammation	E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89	ADORA3;
K00-K95: Diseases of the digestive system	Inflammatory bowel disease	K50, K51	DRD2;
D50-D89: Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism	Idiopathic thrombocytopenic purpura	D69.3	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Epileptic seizures	G40, P90, R56	ACHE; ADK;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Emesis	R11	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Alzheimer disease	G30	ACHE; DRD2;
S00-T88: Injury, poisoning and certain other consequences of external causes	Allergy	T78.4	ADORA1; DRD2;
J00-J99: Diseases of the respiratory system	Allergic rhinitis	J00, J30, J31.0, T78.4	ADORA2A;
I00-I99: Diseases of the circulatory system	Acute and chronic heart failure	I50	ADORA1;
E00-E89: Endocrine, nutritional and metabolic diseases	Acromegaly	E22.0	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis	G70.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Myasthenia gravis diagnosis	G70.0	ACHE;
C00-D49: Neoplasms	Lymphoma	C81-C86	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Psychosis	F20-F29	DRD2;
G00-G99: Diseases of the nervous system G00-G99	Epilepsy	G40	ADK; CASP1;
C00-D49: Neoplasms	Colorectal cancer	C18-C21	TP53;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Advanced stage Parkinson's disease	F02.3, G20	DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Alcohol use disorders	F10.2	DRD2;
NA: NA	Hyperaemia	NA	DRD2;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Nausea	R11	DRD2;
C00-D49: Neoplasms	Late-stage solid tumors	C00-C75, C7A, C7B, D10-D36, D3A	TP53;
NA: NA	Early satiation associated with functional dyspepsia	NA	ACHE;
O00-O9A: Pregnancy, childbirth and the puerperium	Postpartum haemorrhage	O72	DRD2;
J00-J99: Diseases of the respiratory system	Chronic obstructive pulmonary disease	J40-J44, J47	ADORA2A; DRD2;
A00-B99: Certain infectious and parasitic diseases	Helminth infection	A00-B99	ACHE;
C00-D49: Neoplasms	Hepatocellular carcinoma	C22.0	ADORA3;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Huntington's disease	F02.2, G10	DRD2;
C00-D49: Neoplasms	Clear cell renal cell carcinoma	C64	CA9;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Cocaine addiction	F14.2	DRD1;
A00-B99: Certain infectious and parasitic diseases	Pediculus humanus capitis	B85.0	ACHE;
G00-G99: Diseases of the nervous system G00-G99	Pain	G64, G90.0, R52, G89	ACHE; ADORA2A; DRD1; DRD2; ADK;
G00-G99: Diseases of the nervous system G00-G99	Parkinson's disease	G20	ACHE; ADORA1; ADORA2A; DRD1; DRD2;
L00-L99: Diseases of the skin and subcutaneous tissue	Diabetic foot ulcer	L88-L89	ADORA2A;
C00-D49: Neoplasms	Acute myeloid leukemia	C92.0	TP53;
H00-H59: Diseases of the eye and adnexa	Open-angle glaucoma	H40-H42	ACHE;
H00-H59: Diseases of the eye and adnexa	Ophthalmic disease	H00-H59	DRD2;
H00-H59: Diseases of the eye and adnexa	Glaucoma	H40-H42	ACHE; ADORA1; ADORA2A; ADORA3; DRD2;
F01-F99: Mental, Behavioral and Neurodevelopmental disorders	Dementia	F01-F07	DRD1;
R00-R99: Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	Depressive fatigue	R53.82	DRD2;
K00-K95: Diseases of the digestive system	Dermal necrosis	K05	DRD2;
E00-E89: Endocrine, nutritional and metabolic diseases	Diabetes	E23.2, N25.1	ADORA1;
H00-H59: Diseases of the eye and adnexa	Chronic glaucoma	H40-H42	ACHE;

Data Section	Select to Download
1. General Info & Plant Usage & Geographical Distribution
2. Human Target Proteins
3. Target Gene Ontology
4. Target KEGG Pathway
5. Related Human Diseases